Basic Information

Gene Symbol
-
Assembly
GCA_033558755.1
Location
JAKGSA010000734.1:16525-22636[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 6.9 4.9e+02 1.9 0.1 2 16 73 87 73 89 0.79
2 28 0.00027 0.019 15.7 1.0 1 21 162 182 162 183 0.95
3 28 0.09 6.4 7.8 5.0 1 23 216 239 216 239 0.96
4 28 0.014 1 10.3 1.6 3 23 246 266 245 266 0.97
5 28 0.67 48 5.1 5.5 3 21 271 289 270 290 0.94
6 28 0.0019 0.14 13.1 2.8 3 23 334 355 332 355 0.96
7 28 0.0053 0.37 11.7 0.7 1 23 388 410 388 410 0.98
8 28 0.002 0.14 13.0 0.8 1 23 416 439 416 439 0.97
9 28 0.0062 0.44 11.5 1.6 2 23 449 471 448 471 0.95
10 28 0.017 1.2 10.1 7.6 1 23 480 502 480 502 0.98
11 28 0.0018 0.13 13.2 1.2 2 20 624 642 623 644 0.93
12 28 2.7 1.9e+02 3.2 0.1 3 13 650 660 649 670 0.77
13 28 0.1 7.2 7.7 0.2 3 23 677 698 676 698 0.94
14 28 0.00056 0.04 14.8 0.8 2 23 704 725 703 725 0.97
15 28 0.0008 0.057 14.3 1.4 1 23 761 784 761 784 0.93
16 28 0.093 6.6 7.8 3.4 1 23 790 812 790 812 0.95
17 28 3.6 2.5e+02 2.8 0.5 1 23 846 869 846 869 0.87
18 28 2.7e-05 0.0019 18.9 3.9 1 23 874 897 874 898 0.95
19 28 0.0029 0.21 12.5 1.3 2 21 1007 1026 1006 1027 0.94
20 28 3.2 2.3e+02 2.9 0.0 3 23 1034 1055 1033 1055 0.95
21 28 0.22 15 6.6 2.8 1 23 1060 1083 1060 1083 0.97
22 28 0.0012 0.084 13.8 0.2 2 23 1089 1110 1088 1110 0.96
23 28 0.71 50 5.0 1.3 2 21 1114 1133 1114 1134 0.91
24 28 2.4e-05 0.0017 19.1 1.4 1 23 1160 1183 1160 1183 0.95
25 28 0.0015 0.11 13.4 0.4 1 23 1189 1211 1189 1211 0.92
26 28 0.11 8 7.5 0.1 1 23 1217 1239 1217 1239 0.97
27 28 0.0043 0.31 12.0 0.8 1 23 1245 1268 1245 1268 0.94
28 28 0.0003 0.021 15.6 1.7 2 23 1275 1297 1274 1297 0.95

Sequence Information

Coding Sequence
ATGACCCGACAAGTCGATGTGAAGGCTCTAGTCTCTCACATAGTGCGCGGAGACGGCGCTAATAAGTGCCGAATATGTTTGGGTGATACTACAGAAGGACAAGTGTATTTAAACGATACCGTGATGATGGATGGTGATAAACCAGTTACTTTATCAGAAATATTGGAAACCATAACGGGAATACAGGTGGAGATAGAGGGAGACTTACCTGATGGAGTGTGTCCAGAGTGCTCCAAATCTGCCGTTAACGCTGCCAAGTTTAGATCTCTATGTCAAGAGGCAGTTCGGCAATGGAACACGACTATTGCATTACTCCATGACCTGCCGACTCAATGTACAGATAACAAAACTATATTTGCTATAATCAATAAAACTCAAATGATTGCTATTAATGATATGAAGCAATCATATAATCGTACCACAGCAGCTCAGagactaacaaaatatttatcgaAAACCACTGAATCCAAAGAGGATAGTGTATTCAAGTGTCCAAATTGTGAAAAAACATTCTCAAATCCCTTTAAATTCAGTCTGCATTTGAAGGAATCTTCAGATTTACAGCGAGCATGTTACGTCTGTGGTGTTATCATATCACATAAAGATTTGCTAAGCCACTTATCAAAAGAACATAAGGAGAAACCATACAGTTGTAAAAAATGTACTGCTATATTCTGTTCTTACAACCAATATATGCATCATATAGATAAAGCACATAAATTTGGCCGAGCCTTTTGTGGTGACTGTGGACGCAGCTTTCAGTCGATTCATGCATATCATGCTCATCTCTCGGTGCATACATCCAAAAACTGTCCCAGCTGTGACAAACTATTCCGCAACcactcctgctatatgcatcaCACTAAATACTGTTGTGAATTAGATACCaagaaaaaaatagtgaaaacaaaaaagaaagttactatagagataaaaaataagaaaagcaATTGTAAAATCAAAGTGGGGCCCCGAGGAGCTGCCAACAAAGAGTGTTTATGTGATTATTGTGGGAAAAAGTTTGCAAAGAAGAAGTTGATATGTGCTCATATACAGATAGTGCATATGAAGAACACACACCGTCCTTGTATTTACTGCGGCAAGCTGTTAGCATCAGCTCACATGACCGAGCACATGAAAAGACATGAATCAGATCGAACCTTCACCTGTCAGCAATGTGGCTTAGTCTTGAAAAGTAAATTGGGGTATAATCAGCATTTGCGTCTCCATACAGGAGAAAGGCCTTACGAGTGCAAATTTTGTGGCGAAACGTTTTCGGCGTCGTCAAGACGATCGGAACATATACGGAAAGTTCATAAAAGTTCGGATATAGTGCTGAAGCAGAAGTGCCATCTTTGTCCAGCGAAGTTTAGGCTTCCTTATCGCTTGAAGAAGCATTTGAAGGCGGTCCATAATGATGACCAGGACCTGACCCAATTTGAGTGTAACGTGTGCCATGAGAAGTTCAGTTCTTGCCGAGGACTGCTACATCATAGTCGGAAACATCAAAATGTCTCCTTGCCTAACAGGAAACCAgagaaaattGTGGTGGAAGAAACCGACCTGCCCGCGGGATTGTGCTGCGCCTGCGCAGAAAACGCCAAATCGGCGTGGCAGTTCAAGCATCTATGCCAAAAGTCGCACACCCACTGGACTGAGATTACCACAGCCCTGATGAAAACTGACAACCCAACTGCGAAAGATAAGGCCTTTTATATATCGAGCTCTGGCACAGTTATCAAAGATTATGCGACTAACATTCATTCTCGAAAAGATGCTATGAGAAGATTAAACTTTTTGGCCGGCGCCAAACGTAGGACGCGAGCGAAGTATAAGAAGAAAAGTTCACAAAAAGATGACAGTAAATGCAAATGCAAGGTTTGTGGTAAACAATTTGAGTTGCCTTATTTCTTGAACCGCCATTTGATAAATTCGTCAGTTCGCGCGTGCACGTTGTGCGGGAAGGTTGTGTCGCGGGAGAAGTTACCGATGCATTTAGAGAGGGTTCACCAGCGTTTGGTCCAATTTTGCGATATTTGCTATAAACTTTTTGATGACAAACCCCTTTTGGATCGGCACAAGGAGATATTGCATGCAGACAGTAGCTTGCAATGCAATGTATGTAGAAACGGGTTCAAAAGTGAAAGGTCTCTAAGAGCCCATATGTACACACATACGCTATTTAACTGTTCCTCCTGCAACAGCAGTTTTGAAAGCCTAAAATGCTATCTGTACCACAGGAACAACTGCAAAGGATCCAAGCTTTCAAGTCAAGGTATTTACGAATGTCATGATTGTGGGAGTAAGTACACCAAAAAACCGTCTTTAAGAGTCCACATAGTTCAAAAACATTTAAACGTTCTTCCCTACATTTGTCAAATTTGTGGGAAGCGAAGTTCGTCGAAAACCCACCACCAGTCCCACGAACTGGTTCACAAGACCGAAAGGAAGATTTACCAGTGCTACTGTGGCGCGAAGATGAGAACAGTGCAAGGTTTCCAAATGCATCAAAGGATTCATTCGGGGGAGAAACCCTATGTGTGTCAGGAATGTGGGGACAGGTTTCTGTCAGCTTCTAGAAGATTGGATCACATAAAGAGGAAACATAGACGGAGGGATCATTGCTGTGATGAGTGTGACGCAAGGTTTGTGAGACCGTCCGAGCTGAAGAAACACTGGAGGACTGCCCATCACGTGCAAGAAGACCAACTATTCCCGCGAGGTCTGTGCGTCTCCTGCACCAGGGTCGCTGTGTCCGCATCAGAATTCCGAATATTCGTAACAAAATCACAGCGGCTATGGTCCAACTGTGTAGACTCACTTCATACTCTTCCCAGCCTGAACACTTCTCAGAAATCTCTATACGCGATAGTCCGAGAGAACTTACTGTTACAGACCGTCAACCATTTTGAGGGAAACGCAAAAAATTTAATAGAACACCTTACTAATAGAATTGTGAAAAGAAAGACTTTATTGGTTGAAAGAAAACCTAGGCATCCTAGGACAGGACCAGCTTGTACCTGCACAGATTGTGGGAAGAACTTCCTGAGTCCGTATTACCTAAATATGCACTTACGGAACAGTGGTCAGAAGGAAGCGTGTTGGCTTTGCGGCGCCATGTTGACGCGAGGCCAAGAAATGAAGGAGCACCTCGAGAAAATTCACAAAACCGAGATGTTTATCTGTTCAGAGTGTCCATTGCTGTTTAAAACTGATGCAGATAGGAAGCGTCACACCAAAAAGTGTCATGGTCCTGGAGTTATGACGTGCGCGGACTGTGGGAGAACGTTCCAAAGAAGTGCGTCGTTTGATGTCCATGCGCAAATGCATACGGTACGGACGTGTAGGGCTTGTGGTGCTCAATTTACTAATCGTGGTTGTTACAGAGCGCACAGATCCAAATGTGAACCTGATGCCAAGCCTGACTTAAAAACGATACCGAGAAATAGACGTTCCAATATTCGTGACCCCGCTACCTTCACTTGTGACTATTGTGGCAAAACCTACCACTCGCGTCcccaattaaaaaatcatatactaTGGATTCACATGGACATACGACCTCATCAGTGTCAGTGGTGTGGAAAGCGGTTTTACACGCCAGCCCGTTTGGCTGAACACTCGGTAGTTCATACTAGAGTGAGAAACTTTGAGTGCGATATCTGTGGTGCTAAGTTAGTGTCCAAAATGGCGGCGGTGTACCACAGGAGACGGCACACGGGGGAGAGACCGTACGAGTGCACGGATTGTGGGGAGAAATTTATATCTTCATCTCGAAGGTCGGAACACGCCAAGCGAAGACATAACAAAGGCTCTCGCATCCATTGCCCGGAATGTCTGGCAAGTTTTGTAAGAAAtcatgaattaaaaaaacacatggaCAAAATACATAACAATGAAAATCATGTTGTAGTCAAAATAAAGAAGGAAAGCAAAGAGTTTGACATTAAGGCTGTATGA
Protein Sequence
MTRQVDVKALVSHIVRGDGANKCRICLGDTTEGQVYLNDTVMMDGDKPVTLSEILETITGIQVEIEGDLPDGVCPECSKSAVNAAKFRSLCQEAVRQWNTTIALLHDLPTQCTDNKTIFAIINKTQMIAINDMKQSYNRTTAAQRLTKYLSKTTESKEDSVFKCPNCEKTFSNPFKFSLHLKESSDLQRACYVCGVIISHKDLLSHLSKEHKEKPYSCKKCTAIFCSYNQYMHHIDKAHKFGRAFCGDCGRSFQSIHAYHAHLSVHTSKNCPSCDKLFRNHSCYMHHTKYCCELDTKKKIVKTKKKVTIEIKNKKSNCKIKVGPRGAANKECLCDYCGKKFAKKKLICAHIQIVHMKNTHRPCIYCGKLLASAHMTEHMKRHESDRTFTCQQCGLVLKSKLGYNQHLRLHTGERPYECKFCGETFSASSRRSEHIRKVHKSSDIVLKQKCHLCPAKFRLPYRLKKHLKAVHNDDQDLTQFECNVCHEKFSSCRGLLHHSRKHQNVSLPNRKPEKIVVEETDLPAGLCCACAENAKSAWQFKHLCQKSHTHWTEITTALMKTDNPTAKDKAFYISSSGTVIKDYATNIHSRKDAMRRLNFLAGAKRRTRAKYKKKSSQKDDSKCKCKVCGKQFELPYFLNRHLINSSVRACTLCGKVVSREKLPMHLERVHQRLVQFCDICYKLFDDKPLLDRHKEILHADSSLQCNVCRNGFKSERSLRAHMYTHTLFNCSSCNSSFESLKCYLYHRNNCKGSKLSSQGIYECHDCGSKYTKKPSLRVHIVQKHLNVLPYICQICGKRSSSKTHHQSHELVHKTERKIYQCYCGAKMRTVQGFQMHQRIHSGEKPYVCQECGDRFLSASRRLDHIKRKHRRRDHCCDECDARFVRPSELKKHWRTAHHVQEDQLFPRGLCVSCTRVAVSASEFRIFVTKSQRLWSNCVDSLHTLPSLNTSQKSLYAIVRENLLLQTVNHFEGNAKNLIEHLTNRIVKRKTLLVERKPRHPRTGPACTCTDCGKNFLSPYYLNMHLRNSGQKEACWLCGAMLTRGQEMKEHLEKIHKTEMFICSECPLLFKTDADRKRHTKKCHGPGVMTCADCGRTFQRSASFDVHAQMHTVRTCRACGAQFTNRGCYRAHRSKCEPDAKPDLKTIPRNRRSNIRDPATFTCDYCGKTYHSRPQLKNHILWIHMDIRPHQCQWCGKRFYTPARLAEHSVVHTRVRNFECDICGAKLVSKMAAVYHRRRHTGERPYECTDCGEKFISSSRRSEHAKRRHNKGSRIHCPECLASFVRNHELKKHMDKIHNNENHVVVKIKKESKEFDIKAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00781193;
90% Identity
-
80% Identity
-