Basic Information

Insect: Philaethria dido
Gene Symbol: PAX6
Assembly: GCA_033558755.1
Location: JAKGSA010000688.1:132778-183011[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.3e-73 2e-69 231.7 0.6 1 125 72 196 72 196 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.3e-73	2e-69	231.7	0.6	1	125	72	196	72	196	0.99

Sequence Information

Coding Sequence: ATGCCGTCTCGAGGGTGCAGCGTGGCGCTGCACGGGGGGTGGGGGCGGGCGCCGGCGCCCGCGCACGCCGCCACCACGCTGGTCGGCGGGCTGGTAGCGCCGCCGCGGGAACCCACCACGGCGGCCGAGGCGTTTTGGAAGATGCCGCACAAAGATGAGTTGATGCACAGTGCGGCAATGGGTGGCGGAGCCCTATTCGGGTGCTCCTCAGCTGGCCATAGCGGCATCAACCAGCTGGGGGGAGTCTACGTGAACGGGAGGCCGCTGCCCGACTCCACCAGGCAGAAGATAGTGGAGCTCGCGCACTCCGGCGCCCGGCCTTGCGACATCAGCCGCATCCTGCAGGTGTCCAACGGCTGCGTGTCCAAGATACTCGGCAGGTACTACGAGACGGGGTCGATAAAGCCCCGCGCTATCGGCGGGTCGAAGCCGCGGGTGGCCACCACTCCCGTAGTGCAGAAGATCGCGGACTACAAGAGGGAGTGCCCTTCCATCTTCGCGTGGGAGATCAGGGACCGTCTGCTAAGCGAGAACGTGtgcaataatgataatatacctAGTGTATCATCAATTAACCGAGTGCTAAGGAACTTGGCATCTCAGAAGGAACAAGCGGCGTCAGCGCAGAACGACAGCGTTTACGAGAAACTGAGAATGTTCAATGGTCAAGCAGCGACGGGGTGGTGGTACCCTGGCCTTCCCACCGCACCTGCTGCTCCCACGCTACCTGCGCCTCTACCGCCTCAGCTAAACAGGCCGGGGAATACTGAGGAGCATAAACGAGACACCCTGCAATCGGAGGCCGGTTCAGATGGTAACAGTGAACACGCGTCGTCAGGAGATGAAGACTCGCAGATGAGATTGCGACTGAAGAGGAAGCTGCAGAGGAACCGAACATCCTTTACTAACGACCAGATCGATAGCCTTGAAAAAGAGTTCGAGCGCACGCACTACCCAGACGTGTTCGCGCGCGAGCGGCTCGCTGAAAAGATTGGATTGCCTGAGGCACGTATCCAGGTGTGGTTCTCTAACCGTCGTGCGAAGTGGCGACGTGAGGAAAAACTTCGTAGCCAGCGTAGAGACGCGCCCGCctcgccgcccgcgccgcccgcccgACTGCCGCTCAACGGCGGATTTAACTCCATGTACAGTCCCATACCGCAGCCTATTGCCACCATGAGTGATACTTATAGCTCAATGTCGGGCGGGCTATCGTCGTCGTGCCTGCAGCAGAGGGACGGCGGCTACCCGTACATGTTCGGCGACGTGCTCGGCAGCGGCGGCTACTCGAGAGCGCCGGCCGCGCATCAACAGCACGCCGCGTACTCACAACCACAAGCCGCGGCCAGTACTGGTGTGATATCGGCGGGTGTGAGCGTGCCAGTACAAATACCATCGCAGGGGCCGGACCTCGCATCCAACTACTGGGGACGACTTCAGTGA
Protein Sequence: MPSRGCSVALHGGWGRAPAPAHAATTLVGGLVAPPREPTTAAEAFWKMPHKDELMHSAAMGGGALFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSENVCNNDNIPSVSSINRVLRNLASQKEQAASAQNDSVYEKLRMFNGQAATGWWYPGLPTAPAAPTLPAPLPPQLNRPGNTEEHKRDTLQSEAGSDGNSEHASSGDEDSQMRLRLKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRSQRRDAPASPPAPPARLPLNGGFNSMYSPIPQPIATMSDTYSSMSGGLSSSCLQQRDGGYPYMFGDVLGSGGYSRAPAAHQQHAAYSQPQAAASTGVISAGVSVPVQIPSQGPDLASNYWGRLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01181744; iTF_01138914; iTF_01144394; iTF_01149419; iTF_01138802; iTF_01149555; iTF_01144502; iTF_00913575; iTF_00913442; iTF_01148722; iTF_01148777; iTF_01147349; iTF_01147302; iTF_01282242; iTF_01282058; iTF_01124435; iTF_01124563; iTF_00986022; iTF_00985830; iTF_00858382; iTF_00858509; iTF_01463093; iTF_01463220; iTF_00177910; iTF_00178123; iTF_00146393; iTF_00146226; iTF_00250298; iTF_00250425; iTF_00844315; iTF_00844152; iTF_01178531; iTF_01178243; iTF_00875270; iTF_00875141; iTF_00280968; iTF_00281221; iTF_01205544; iTF_01205667; iTF_01203881; iTF_01204005; iTF_00213258; iTF_00213411; iTF_00248042; iTF_00247877; iTF_00782603; iTF_00782479; iTF_00775218; iTF_00775101; iTF_00164332; iTF_00164197; iTF_00621196; iTF_00621064; iTF_01072460; iTF_01072332; iTF_00786605; iTF_00786753; iTF_00621966; iTF_00621860; iTF_01245904; iTF_01245774; iTF_00007057; iTF_00006923; iTF_00357457; iTF_00357257; iTF_01079025; iTF_01078960; iTF_00076498; iTF_00076295; iTF_00347442; iTF_00347346; iTF_01388434; iTF_01388300; iTF_00651572; iTF_00651713; iTF_00984916; iTF_00985066; iTF_01193557; iTF_01193446; iTF_00358358; iTF_00358529; iTF_00842486; iTF_00842633; iTF_00875990; iTF_00876132; iTF_00878710; iTF_00878820; iTF_00942646; iTF_00942790; iTF_00282103; iTF_00282310; iTF_00461527; iTF_00461392; iTF_01336663; iTF_01336809; iTF_00421305; iTF_00421195; iTF_00457081; iTF_00457197; iTF_00774457; iTF_00774352; iTF_00407546; iTF_00407404; iTF_00710170; iTF_00710023; iTF_01041722; iTF_01041581; iTF_01281306; iTF_01281141; iTF_00159803; iTF_00159663; iTF_00318716; iTF_00318831; iTF_01034556; iTF_01034369; iTF_01133693; iTF_01133557; iTF_01153693; iTF_01153946; iTF_01561085; iTF_01560971; iTF_00680510; iTF_00680360; iTF_00933566; iTF_00933720; iTF_01508030; iTF_01507905; iTF_00114912; iTF_00114777; iTF_00275232; iTF_00275089; iTF_01437856; iTF_01437943;
90% Identity: iTF_01181744; iTF_01034369; iTF_00842633; iTF_00461392; iTF_00842486; iTF_00461527; iTF_01034556; iTF_01178531; iTF_01178243; iTF_00875270; iTF_00875141; iTF_01205544; iTF_01205667; iTF_01336809; iTF_00858509; iTF_00858382; iTF_01336663; iTF_00077449; iTF_01073580; iTF_01073441; iTF_01403276; iTF_01403399; iTF_00819892; iTF_00820041; iTF_00177910; iTF_00178123; iTF_00942646; iTF_00942790; iTF_00844315; iTF_00844152; iTF_01251581; iTF_01251706; iTF_01416605; iTF_01416749; iTF_01083295; iTF_01083135; iTF_00213258; iTF_00213411; iTF_00248042; iTF_00247877; iTF_00782603; iTF_00782479; iTF_00775218; iTF_00775101; iTF_00164332; iTF_00164197; iTF_01072460; iTF_01072332; iTF_00786605; iTF_00786753; iTF_00621966; iTF_00621860; iTF_01245904; iTF_01245774; iTF_00007057; iTF_00006923; iTF_00357457; iTF_00357257; iTF_01079025; iTF_01078960; iTF_00076498; iTF_00076295; iTF_01388434; iTF_01388300; iTF_00984916; iTF_00985066; iTF_00358358; iTF_00358529; iTF_00875990; iTF_00876132; iTF_00878710; iTF_00878820; iTF_00457081; iTF_00457197; iTF_00774457; iTF_00774352; iTF_00710170; iTF_00710023; iTF_00874426; iTF_00874340; iTF_00159803; iTF_00159663; iTF_00318716; iTF_00318831; iTF_00744445; iTF_00744603; iTF_01153693; iTF_01153946; iTF_01157501; iTF_01157703; iTF_01561085; iTF_01560971; iTF_00933566; iTF_00933720; iTF_01508030; iTF_01507905; iTF_00114912; iTF_00114777; iTF_00275232; iTF_00275089;
80% Identity: iTF_01181744;