Basic Information

Gene Symbol
ZFX
Assembly
GCA_905333125.1
Location
HG995407.1:9309920-9318952[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 2.1 1.2e+02 3.5 0.4 2 23 6 27 5 27 0.96
2 13 1.5 92 3.9 0.1 1 23 1026 1049 1026 1049 0.92
3 13 1.6e-05 0.00096 19.6 1.7 2 23 1149 1170 1148 1170 0.97
4 13 0.0006 0.035 14.7 2.3 1 23 1176 1198 1176 1198 0.98
5 13 0.0077 0.46 11.2 2.5 2 23 1205 1226 1204 1227 0.95
6 13 1.3 75 4.2 1.0 5 23 1240 1258 1239 1258 0.96
7 13 0.019 1.1 10.0 1.1 3 23 1265 1286 1264 1286 0.96
8 13 0.02 1.2 9.9 0.1 2 23 1303 1323 1302 1323 0.96
9 13 0.00016 0.0097 16.4 2.7 1 20 1329 1348 1329 1351 0.91
10 13 0.00018 0.011 16.3 0.2 1 23 1359 1381 1359 1381 0.98
11 13 0.0054 0.32 11.7 7.2 1 23 1387 1409 1387 1409 0.98
12 13 6.3e-06 0.00038 20.9 1.3 1 23 1415 1439 1415 1439 0.98
13 13 0.00099 0.059 14.0 5.1 1 23 1445 1467 1445 1468 0.95

Sequence Information

Coding Sequence
ATGGATCAGCTTGTGCAGTGCCCCGTGTGCACGCTATTCCTCCACAATGGGATGACCCTTGAGTCACATCTAGATACCCATCCCAAAGACCAAGTGATTAAGGCACTGTGCAGTCTGACAACCAAGGGATCCAACTATGGAAGCAGGACTTCCACGCCCCTCCATTCGGAGAGATCATACAGGAGCAGGTCACGGACACCTGCTACCGAGGATAGTGGGCGATGGAATGGTTCCCATCGCAGCACAGAACCGGATCGCTACTGGCGTCGAACACCAAGTAGGACTCCTAAGACAAATCCTATTTCAAGTGTATCAAGAAATAGCACTCCTGATATCAGAATAAATGAAATGAACTTTGAAAGTGGTTCCATAAACAGTGCAGGGACGCACACTCCATTTGTGATGAAGGCTGATAAAATCCAGCAAACCTACCAGCCCCCACCAGTAACAGATTTTGATCCGCAATATGTGTACTACCCGGATCAGCAGGAGGACAGGGAGATCAAGTATTCCCGGAGTGCCGAATACAATGCAATGGACAGCACTAACAATGTGTTCACATATAACATGCCAACCATAGGGACCGGTGTGAAGTTGTTACCAGCAGTGCCCAGAAGGACTAATGATATTGTTAAAATTTTGCCAAAACAAAACAATATACTACTGAAAACTAACATGGGTGGGGTGCAATACATAAGCCCTGGAGTAAAACCCATGCATGTTGTTGTGCCTACAGCCCCAACATTCCTTCAAAAGAATGTCCAGAACAATATGATTGTGACAAGTAACATACCAAATGCACAGGTTCAGATTGAGACAAAATCAATTGCTCCTCCGTTAACAACCAATTTGAACCAGATGACCTCGAACACATTTACTCCAGGAACCACAGTTGTCACACAGAACTCACAAATTATCTACCGCGAGATGGTTCATAATATAGACGGTAAGCCCTTTATAACTAGCATGCCGACTGTACTTAGTGGTCATGACAATGTTACTAATGTTGCTCAAGCCAGTTCTATGTACCAAAATGTGATGGTTGTGGACCAATTTGGCAATACTTCATGTATGTACACAACACCTCAACAGATTCTTCCTAAATCTTGTACCACTTCAATATACAATAACAATGGGCCACTTGTTCCTGGTATCCATATGGAAAAACCTGTTGCAAACTTGAATGATCCCAAAACTCTTATAATTGAAGTAGGTCCTATGGTGCCAGCACAAGACCATGCTTCCAGTTCCTCCTGTGAAGCATCTGTCTCCAACATTCGACAGACAGAAACTAGTGCAACTGAGAAGCTTGAGAGACCTACAAATGAGGTTGAAATGAGAAATGACACACCTGGCGCTAGTAAAGGTTTAAAGATCCTCAGTAATATTAAAGTAGAAGTTCCTGTGCAACATCACAAGAACATGGTGAATACCATCATGGATTTAACCGGGCCTAGTGAGACAGATTATTCTGTACGTCCAGCATCACCTGATAAAATTTTGCCTGACCTAGATGATAATCAAACAGAGGCTGAGAAGATTCTGCCTGATTATGATGATAAAACCCAGATGATGGCCAATCCTGAGAGAATCCTGCCTGATATTGATGATAATAATCAGATTATAATGGATGAATCCACGCAGCCCTCTATGTCGAGCGCCGATAGCATAGTTTCCCACTCATTTTCTGTGATAAAAAATGTTGGTAATCCTCCTTCTTATAAAGACTTGAGCAAGAACTCTGATAGTAAAATGGACGCTGATTTCTCTGACAGCTGCCCCGTTCCCGATTTAATATGTAATGAGAAACCATCCATATCGCCGTGCAGTGAGTTATCAGAGAACGGCGACAACTCAACCGATCGTACCTCAATCTCGCCTAAACCAGAGTGTAGCCAAATAAGCAGTAGTGTAAATGTTGCACAGAAGAAAACTCAAAGTCCTCAAAGGCCGTACAGACACAACACATTAAGACTGAACAATATTTTTGTGAAGAAGCACAAGAAAGTGTTGCAAATAAAGAATGCCAAACCCTTTCCTGTAAGTAGTACATGTGAAAATGAGATAGAACCGATGCCATCATCGTCGACCTGCAGATCGCCCGAAAATTTTACTATGAATAAAATACATTACATAGACAAGGTTGAAAAAGAGATAGGCAATGTATTGCACACTATATCTGTAGAGGTGATCAAGGAGAATGATGATAACAATGACTTTGATGCTGACACAGAGGAACAGTCGATGGATATTGAACCGGTAGCACCGTCGAGTATAAGTCATTCCAATGAGTTTTCATCAAACGACATGGTGCGTGTGAAAGAAGAGATAAATACGAGCAACGAAGGAGGGTTCAGCAACCAGGGCCGCGTGCTCACGCGCCTCGAAACATTGCGTCCGATCAATGTTATAACGTACGGAAACATACCGACGGAGGATTTCGATGACGAATCAAATGATAGGGAGTTATTAGACCTCGAAGCGGCGTCTAAAAACAAGCAGTTCGTTACAATGATGAACGAGAATTACTTCGGGGACAATATTTACGCGGATTATTTCACGACCGATCGGGTGGAGTCGTTTAATGCGCGCGAGTCGGCGGGGTACAAGGAGCCTCCTAAAGATGGCATGTACAACATTTGGGGTGAACCATCTCAGATGCAGAAAGAGAATGAGTTCGTACTCCCGAACTTTATACACGAGAGCTATAAGATAGCCGAGAGTGCTACAGGGGAGTATTCGGAGATGGGTTCTAGGGAGGGAGCGGGCGAAAGGAATGTTGACGGGTGTGAGAGGGACAGTAAGGTGGATGTGTTGAGTGAGAGTAGGAGCGAGAGTGAGGCTCCGCTGAACATCTGTGCGGATGAGCGGATGCCGCCGCGCGGGGAGCTCAGTGGACAGGAGAGTAATGGCGATATGGAGTCTCCTTGGACTGGGATGTACAGCGAGATGGCGCCGACGGAGCCGTACGATCTGATTGCGCGCGAGAGCTGGGTCTCGGACGGGTCGGATTTGGATACCACCGAGAAGAGGGATACACTGGAGGAGGAGCTCCAGTTCGCCAAGTCCCGGCTGTACACGTGCGCGCAGTGTCGCGCGAAGCTGCCCTCTATGAAGGAGCTGCGCGCGCACAAGGCGCTGGCGCACGCCCCACCCGCCGCCAGCGCCACCTACAGCCGCCTCGTCACCGCCAGGACTATCAAGAAGGAGGAGAGGCATGACAAGATTACCCTAACCAATAACCTCCTAACATTGGACACCAAAGAATCAATAACATCCACAATACTTGAAGTGTACGAGACCATAGACGAGTCGAAGCCGAAGATCGAGGGCCTCATCAAACAGGAGCCGAAGCGGCGGCGGAGGGATTACGTGTGTCCCACATGCAAGGTGGACCAGCTGAACGACCTCGCGTTCCACGAACACTTGAAGATACATCCGCTGGAGTGCCTCACGTGCGGAAAGTGCTTCTTCCGAAGGGCCAATTTGGCGTTGCATATAAAGACGCATTTAGGAATTAGAAATTACAAATGCGACGTGTGCGAGAAGCGGTTCATGACGCGGCAGAAGCTGGCGGAGCACCACAACGTGCACACGGGCCGCGCGCCCGTCAAGTGCACCGTGTGCGACGACACCTTCCGCCGCTACTCCAACATGGTGCAGCACAGGGACCGGCACCACTTGCAGAAGCGCGCCAAGGTGCGCGACTTCGTGTGCCAGTGCGGCGGCGTGTTCCACTCGCGCGCCAAGCTGCTGTGGCACCGCGAGACGCACGACGACAAGCCCAAGGCGTGCCTCTACTGCAGCGACAAGTTCGTGCACGCCGCCTCGCTCACGCGCCACGTGCGCCGCTCCCACAACGAGTACTTCCTCTCCGACCGGCTCAAGGGCAAGGCGGAGAACGTGCCTTGCCCCGTCTGTAAGCAGGTATACCTGAGAACGAACCTGCGCGCCCACCTCCAAATACACAGCGGGCAGCGCCCCTTCCACTGCGTCATATGCAACAAATCGTTCACAACCAAATGGAACCTGAAACTCCACCGGTGGACCCACATGAGCCGCTCCGCGAAGCCCTTCAAGTGCACACTGTGCAAGGGCGCCTTCATCCGCCAATCGGAGTACATCGCACACATGAACGCCCACAAGTCCGTCAGGCCGTACACCTGCAACTACTGCGGCTGCCAGTTCATAAGGAAATACAACTGTCAGCGGCACGTCCGCGAGCACGAGATGGCAAAGAAGTATGTGTGCAAAGTACCCGAGTGCGGTAAGTCGTTCCATCGTAGCTATTATCTGTCCGAGCACATGAAGGTGCACAGCGGGGCGCGGCCGTTCTCGTGCAACATATGCGGGAAGACGTCGAGCAATAAGTCGAACCATAATAAGCATGTTAAGATACATCACGCGCGGGAGCCCGTCGCTACTGAGGCGTAA
Protein Sequence
MDQLVQCPVCTLFLHNGMTLESHLDTHPKDQVIKALCSLTTKGSNYGSRTSTPLHSERSYRSRSRTPATEDSGRWNGSHRSTEPDRYWRRTPSRTPKTNPISSVSRNSTPDIRINEMNFESGSINSAGTHTPFVMKADKIQQTYQPPPVTDFDPQYVYYPDQQEDREIKYSRSAEYNAMDSTNNVFTYNMPTIGTGVKLLPAVPRRTNDIVKILPKQNNILLKTNMGGVQYISPGVKPMHVVVPTAPTFLQKNVQNNMIVTSNIPNAQVQIETKSIAPPLTTNLNQMTSNTFTPGTTVVTQNSQIIYREMVHNIDGKPFITSMPTVLSGHDNVTNVAQASSMYQNVMVVDQFGNTSCMYTTPQQILPKSCTTSIYNNNGPLVPGIHMEKPVANLNDPKTLIIEVGPMVPAQDHASSSSCEASVSNIRQTETSATEKLERPTNEVEMRNDTPGASKGLKILSNIKVEVPVQHHKNMVNTIMDLTGPSETDYSVRPASPDKILPDLDDNQTEAEKILPDYDDKTQMMANPERILPDIDDNNQIIMDESTQPSMSSADSIVSHSFSVIKNVGNPPSYKDLSKNSDSKMDADFSDSCPVPDLICNEKPSISPCSELSENGDNSTDRTSISPKPECSQISSSVNVAQKKTQSPQRPYRHNTLRLNNIFVKKHKKVLQIKNAKPFPVSSTCENEIEPMPSSSTCRSPENFTMNKIHYIDKVEKEIGNVLHTISVEVIKENDDNNDFDADTEEQSMDIEPVAPSSISHSNEFSSNDMVRVKEEINTSNEGGFSNQGRVLTRLETLRPINVITYGNIPTEDFDDESNDRELLDLEAASKNKQFVTMMNENYFGDNIYADYFTTDRVESFNARESAGYKEPPKDGMYNIWGEPSQMQKENEFVLPNFIHESYKIAESATGEYSEMGSREGAGERNVDGCERDSKVDVLSESRSESEAPLNICADERMPPRGELSGQESNGDMESPWTGMYSEMAPTEPYDLIARESWVSDGSDLDTTEKRDTLEEELQFAKSRLYTCAQCRAKLPSMKELRAHKALAHAPPAASATYSRLVTARTIKKEERHDKITLTNNLLTLDTKESITSTILEVYETIDESKPKIEGLIKQEPKRRRRDYVCPTCKVDQLNDLAFHEHLKIHPLECLTCGKCFFRRANLALHIKTHLGIRNYKCDVCEKRFMTRQKLAEHHNVHTGRAPVKCTVCDDTFRRYSNMVQHRDRHHLQKRAKVRDFVCQCGGVFHSRAKLLWHRETHDDKPKACLYCSDKFVHAASLTRHVRRSHNEYFLSDRLKGKAENVPCPVCKQVYLRTNLRAHLQIHSGQRPFHCVICNKSFTTKWNLKLHRWTHMSRSAKPFKCTLCKGAFIRQSEYIAHMNAHKSVRPYTCNYCGCQFIRKYNCQRHVREHEMAKKYVCKVPECGKSFHRSYYLSEHMKVHSGARPFSCNICGKTSSNKSNHNKHVKIHHAREPVATEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00622251;
90% Identity
iTF_01179766;
80% Identity
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