Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0013 36 6.2 0.0 26 52 33 59 29 61 0.90

2 5 7.3e-10 2.1e-05 26.2 0.3 22 46 63 87 56 92 0.83

3 5 0.0011 31 6.4 0.5 21 48 92 119 88 124 0.92

4 5 0.37 1e+04 -1.7 0.0 33 50 133 145 120 147 0.56

5 5 0.88 2.5e+04 -2.9 0.2 27 43 155 171 154 179 0.70

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0013	36	6.2	0.0	26	52	33	59	29	61	0.90
2	5	7.3e-10	2.1e-05	26.2	0.3	22	46	63	87	56	92	0.83
3	5	0.0011	31	6.4	0.5	21	48	92	119	88	124	0.92
4	5	0.37	1e+04	-1.7	0.0	33	50	133	145	120	147	0.56
5	5	0.88	2.5e+04	-2.9	0.2	27	43	155	171	154	179	0.70

Coding Sequence: ATGAAACAGTCATCAATCGTGGTTATTGAATTAATATATCCCAGCAAACGTTTACTCTCATCTCATCTACCCGTCCACAGCACAATTTTCACTTCTATGTGTGATATATGCGGCAATacgtttaaaagtaaattttcccttaaaaaacaTATCGAATATCAACACTCGGAAAATCCTCGTACAGATAAGGAACCTCAACAGTGTCCCATTTGTTACAGAGTCTTAAGAGGCAGTAGGGGACTCAGGGTAcacatgaaaaatatacatgACAACGGCGAACAGGAGCATCGTTGCAAGATTTGTAATCACATTTCAACAACGGCCAAAGGTTTACGAGTGCATGAGATATTTCGTCACgaaaaagagagaaaatacaAGTGTTCTTTGTGTGAAAAGGCGTTTAAGAGGCCTTTGGatttaaaaGAACATTTTGCTACACACACAGGCATCTCTTTGTATAAATGTGCTGAATGTCAGGCGACGTTTAAGTCAAATTCTAATTATTATCATCATAGACGACGTTTTCACAGTGGAAAATCAAAAGGAGATTTAATGATTAAAATTGGTGATTGTCCTTAG
Protein Sequence: MKQSSIVVIELIYPSKRLLSSHLPVHSTIFTSMCDICGNTFKSKFSLKKHIEYQHSENPRTDKEPQQCPICYRVLRGSRGLRVHMKNIHDNGEQEHRCKICNHISTTAKGLRVHEIFRHEKERKYKCSLCEKAFKRPLDLKEHFATHTGISLYKCAECQATFKSNSNYYHHRRRFHSGKSKGDLMIKIGDCP

Sequence clustering based on sequence similarity using MMseqs2