Pobe050118.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Phasia obesa
Gene Symbol
ey
Assembly
GCA_949628195.1
Location
OX451220.1:9706297-9778504[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.7e-73 2.9e-69 232.4 0.5 1 125 51 175 51 175 0.99
2 2 4.1 2.1e+04 -3.0 0.0 30 46 788 804 785 814 0.82

Sequence Information

Coding Sequence
ATGCTGAACGTGAAAGGCGCCGATGCTTACGTATATTTAGCTGCTGTTATGGAATATTTGTCCGCTGAAGTTCTTGAATTGGCTAGTAATTCTGCTTGTGACAACAAAAAGACCATAATCATTCCTCGCCATTTGCAATGGGCTATTCGGGGTCATAGCGGTGTAAATCAGTTGGGCGGTGTGTTTGTTGGTGGTCGTCCTCTACCCGATTCAACTAGACAAAAAATAGTGGAACTTGCACACTCTGGTGCAAGGCCATGTGATATATCACGCATATTGCAGGTGTCAAATGGATGTGTTAGCAAAATTTTGGGCAGATATTATGAAACCGGCAGTATAAGACCAAGAGCTATAGGCGGTTCAAAACCTCGAGTTGCTACTGCTGAAGTTGTTGCGAAAATTTCTCATTATAAGCGAGAGTGTCCAAGCATATTTGCCTGGGAAATACGTGACAAATTGCTGCAAGATGGCGTTTGTACAAACGATAATATTCCAAGCGTATCGTCCATAAATCGCGTTTTGCGTAATTTAGCAGCACAAAAggaacaacagcagcaacatacAATAACCGCATCAGTAGCATCACCAGTTGATAACAATACAACAAATTCAACCACTTCTACAAATGAACTTCAGACAGCAACGCCGCTAAATTCTAGCGAAAGTTCATCTGGCACAACAAATCCAGTAGTGATATCTACAGATATCGCCTTGGATATCAGTTGTTCAACTACAGATTCTATGGTTTATGAAAAACTCAGACTTTTAAACGGTCACTCtgtacatcatcatcatcaccaccaACATTTGCCAAGCCATCATCAATCTGGGCCATCgcatcatcaccatcatcacGCTTGGCCACCACGTCACTACTCATCGCCGTCATCGTCTTGGTATACCTCACCTTTAAACCCTACCAGCAATTTGACGGTAAATAACGCATCCAACACATCCGCGTCGGCGATAGCTTTTCACAGTCAACATCTGAGTCCCAGTGCTTCATCTTTACATAATAATGCCTGTTCTACAGGTACAGAGGATATTACTTTAAAGAAAGaaattgatGGTCACAATTCAGATGAAACTGCTTCTGGTGAGGGTGAAAATTCGAATGGGGGCGTTTCAAATTTAGGCGCCAATGAAGATGATCAAGCTCGTCTGATTTTAAAACGCAAATTACAGAGAAATCGTACATCGTTTTCAAATGAACAAATCGACAGTCTGGAAAAGGAATTCGAGCGCACCCATTATCCTGATGTTTTTGCACGAGAACGATTGGCTGGTAAAATTGGACTACCGGAGGCTCGTATTCAAGTTTGGTTCTCAAATCGCAGAGCGAAATGGAGGCGGGAGGAAAAACTGCGGAATCAACGTCGTACTCCGAATTCAACAGGACCAGTTTCTACGTCCACTAACTCTGCTGCTTCCTTGGCTGACAGTCCCAATAGCAGCAGTGTTGGTGGCAACTCCACTGTTCCACCTGTTATGCCAGTTTCAACCAGCactcgTATGTTTTTTGACTACTTTGGCTACACTACACACTCCACAGATTCTATGACGGATTTAGCTTCACCTTCTTCAATATCCAATTCAGTTGCAGCTGCCAACGGCTCTACCCCATCTTTAACTCCAAGTGGTGGTCATATGGATACAGTGCCAACTGAACATTTAGATGGACCCGTTACTCCGGCTGTACATAGAAGTACCACTACATCTTCTAACAACGACATTAGTCATGGACAAAATAACACTGATCGCAGTAGTAGtagcaataacaacaatttatCCTGCGCAACATCCACCGCAAATAATGGTTTCATACACTCCCTACATCACACTCCATCTACTCCTCATAGCCATAGTATGCATGCGGAGTCACATTTAGGCAGCAGTATTATGCCAACCCTCTCACCACAacgtattaatttaaatagtgGTTTTGGTACATCCATGCCAGCGATATATCCATCTATGCATCATACTGCCATGTCAATGAGCGATACTTATAGCTCTATGGCACCTATGACAAGTTTTGCACACTCACATCCGTCAATAACGTCAATACCAGGTTCACcgatttcacaacaaaaagaTTTAGTGTCGCCTTCTTTGTATCAGTGTCATGTTTCCTTAAGACCTCCAGTTCCATCTAATCATcaccaccatcatcatcatgTCCTTTCAAATGGAGGGTTTGGCACATCATCCGGAAGCGGAAGTTGTAACACCTCAACACAACTGCAACGTATCGGAAGCGGTCCTACACATTCCACACCAACAATTAACTCAGGTCAAAATAATTATGATAGCTTAGGCATATATTCTCATGGCTTGCCACCGCCATCATCAGCATTAGCAACTCACCAAGGAATAAACAGCTGTACTACCGATCGTCAAACTTCTTGTAGTCCCCACACCAACTTGAGCAACAACGTTTGCTTAAGTACCCATGCTGCTGCAGTGCCAACTTCAACTCCTGCACCATATACACAAATGGGCTATAACGGTTATACTGCAGTTGCTGCTGCAGCCAGCTGCAATAATACCAGCAACAGTCCTTCGCCGATACCACATCCATCAACGGGAAAACAGCAGCAATTTTTTGCATCTTGCTTCTATTCACCCTGGGTATAA
Protein Sequence
MLNVKGADAYVYLAAVMEYLSAEVLELASNSACDNKKTIIIPRHLQWAIRGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVAKISHYKRECPSIFAWEIRDKLLQDGVCTNDNIPSVSSINRVLRNLAAQKEQQQQHTITASVASPVDNNTTNSTTSTNELQTATPLNSSESSSGTTNPVVISTDIALDISCSTTDSMVYEKLRLLNGHSVHHHHHHQHLPSHHQSGPSHHHHHHAWPPRHYSSPSSSWYTSPLNPTSNLTVNNASNTSASAIAFHSQHLSPSASSLHNNACSTGTEDITLKKEIDGHNSDETASGEGENSNGGVSNLGANEDDQARLILKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGPVSTSTNSAASLADSPNSSSVGGNSTVPPVMPVSTSTRMFFDYFGYTTHSTDSMTDLASPSSISNSVAAANGSTPSLTPSGGHMDTVPTEHLDGPVTPAVHRSTTTSSNNDISHGQNNTDRSSSSNNNNLSCATSTANNGFIHSLHHTPSTPHSHSMHAESHLGSSIMPTLSPQRINLNSGFGTSMPAIYPSMHHTAMSMSDTYSSMAPMTSFAHSHPSITSIPGSPISQQKDLVSPSLYQCHVSLRPPVPSNHHHHHHHVLSNGGFGTSSGSGSCNTSTQLQRIGSGPTHSTPTINSGQNNYDSLGIYSHGLPPPSSALATHQGINSCTTDRQTSCSPHTNLSNNVCLSTHAAAVPTSTPAPYTQMGYNGYTAVAAAASCNNTSNSPSPIPHPSTGKQQQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01176783; iTF_00921293; iTF_00921385; iTF_01260941; iTF_01260842; iTF_01373909; iTF_00258714; iTF_00258817; iTF_01174173; iTF_01174019; iTF_00921950; iTF_00741823; iTF_00741693;
90% Identity
iTF_01176783;
80% Identity
iTF_01176783;