Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963931995.1
Location
OZ008367.1:354819136-354830140[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.8 2.8e+04 -2.9 0.0 38 62 85 110 62 116 0.73
2 2 2.8e-23 4.2e-19 70.2 0.1 4 76 419 489 416 490 0.93

Sequence Information

Coding Sequence
ATGGGACGCCGGTGTTGTATTGAAAGCTGTTTGTCAACATCACGTTTGCCGGAACATCATGGTGTCACATATCATTCCTTTCCCGTCGATGAGAATACCCGGGCCATATGGATTAGGAATACTAGAATAGATGCACGCCGCAATATAACCAAAAGTGTTTTGGTGTGTTCCCGTCATTTTCGTCGGGCAGACTTTCAGCCGCAGCGTAGTGGAAAGTATTTGTTGAAACAAAAGGTCTTCCCTACTGTCTTTCCATGGGGCAAAGTTGAAGCCAATCAAATTGAGGAGGATTTAGAGTTTCTAAGTAGTACCTCCTCAGCAACTGCGGCAGCGCCCACAAATCTGTTGTCAGCCACCGCTTCTTCGGTGGATGAAGACACCAAAGCAACGGTGGCTGCAACAGTGGCTCAAATAATGGCACAAACGGCCGAGTTAAATGCTCAGGCTGCCTTGAAAGCGGAGAAATCATTTGAGGCCGGCGACGATGCGGCAGCACCCGATGCCGGTCATGGTTCTCCCACGGGTGTTAAATTTGAGCCGGTGACTACATTCAATCCCGGCGCTCGTCTAGAGGCTCAAGATTTTGATAGAATTTGGCATTCTGCCCGTATTGTTGAGGTGGACAATGATGATCGTGAGGTTTTGATAAAATTCGAAAAGACCGGAAAAGTCAAACTGCCCATTGTGGGTACAGAGGAATGGATACCCATGAATTCTTCACGTCTAAGGCAGAAAATATCCACAAAACCTATACTCAACTTTAATGTGGAAGACAAATGTTTGGCCCGTTGGTCAGGACCTAGAAAATTCCCTGGTACCGTAAAGAAAGTACTGCCCAATGATACCTATGAGATTCTATTCGATGATGGTTATATAAAGAATGTTCGAGCCATACATATGAATAAAGTTATGCCCGCAGACGCTGAAGTTGTAGTGGAGAATCCAGCAGTGGAAGGAAGTAACGCGGAGGTTTCACCAAATGCCTCTTCAACGCCTATTGCAGGAACACCTTTATTGTCGCCAGGCATCAAGAGGCCAGCATCATCAGGAACACCTTCAAGTTCGGGCAAAAAGAAACGTGCACCAAGTTCGGCGCGAAAGGACTGGCCTTTGTTGGATCTGTCGAAATTGGATTTGGCCTCTCTCAATCTACCCGAGGTGCCAAAAGATGGTGAATGGGCCTGCCACTGGGTTAACGATCAGCCGATCGGTCGTGAGGGCTTTCTTTTGGTCGGTGAACATCGCAAACCCACGGTGGTTGTTGAAGATTGGCGTTTACCACCCGGTTGGATTAAACACATGTATCAGCGTTCCAATGTTTTGGGCAAATGGGATGTGATTTTGGTTACACCCACCGGCAAACGTTTCCGTTCCAAGGCGGATCTTAAAACGTTCCTCGAGGAACAGGGACAAGTATATAACCCGGATATCTATGACTTTAGTATACATCGGCGAAGGGccaaagacatcaattgttatGTATACACACCGGGTTATGTACCACAACAGCCGGTGAAACCGAAACCCTCATTTGGTCTCGATACAACAATGGATAGTGTCACACCGCCTCCATTGGTTTTGGGAACGCTACCGGCAGTTTCAGTATCCTCACCATACATGGAGACACCCACAGTAGAGCCTTTGCCGCCAATAGAATTGTTAACATCCAGCAATTTGTCGGCAGATTACAAGAGTGTAACACAAGTGGAGGCAGAGGTGCCTAAACAGCTTTTGGAATCAGCAGAAGTTAGTTCAACACCTACTCCCACCACTACACCGACAGTGGGATTAAAGGAGGAAATTGTAGTTAAATCGGAAAACCCACAACTGCCTTCGTCAATTCAGGAGGTGGAGGTAAAGACAGAGCCCATGATATTGGAAACTGTGCCTAAAATTGAAGATGGTTATGCTTTAATTGGGTCCTTGAAGGTGCAAATTATTGATAATCTATTTCGCTGTCCAGAGGAGGGTTGCTTCAAGAATTTCCGCAAAGAGAATCATTTGCAGATTCATGTCAAACACTATCATCGGAATTTAGTCAaATTACTTGGCGCTTGTCCCAAAATGCTGGATCTCGCCGAAAAACGAACCCATCCCATCGGTCATGATCCCAATGAACCAACGCCTAGGAATCAAATACCCAACCAGCAGTTCTTTGCCAAATTGCATCAACAAGACTTAGAACAGACTAGAGCTCATAGACGCAGTGTGGGCGCTCAGAAAGCACAAACAGAAGTGAGTGTGGACATTAAATCGGAATTGTTAGACGGACAAATAAAAGTTGAGACTGGAGAACAACTAACATCATCTCCAATGCAGGACATATCGGCGATAATAAACTCCACTAATGCTTCGTCAGCATCCATTTTGGACAGTTCTTATATGTCAACTGCAGCGGATGATTCAATGGCAACAGCCAGTGAGTCGGCTCTGCCAGATGTCCCCCCTCTCTCCAAGAAGTCCAGATTTTCACCCTTAAAGAAACCTTCAGGCGCAAGGAAGAGTAATCGTCAACGTACCACAAAGAAATATCTTACAGCTGCCCAAGCAACAGCAGGTGTGGTGAGTCAAAACGCTTCTATTGCGCCAGTAGAGTCCAGTTTCAGTGGTGTCACAGATTTCGAAGAAACACGTCACTCATTCAATGCCACTCCGGAAATTCACAAGGATAGCAAGAGACGTAGAACGAACGCCGCTCCACCAGCCACAACCTTCAGTAGTGCTGAATCCCCCATAACAGCAGATTCTGGTTCCAGTTCTCTGCAGCCCTTATCCACAACTGAAACAGAGAGTGCTGCTCAGTACATCAAAGAAAATGGAGAGCTCATCAAGATTGTAAGCATGCGTCAAGAGGAGATCATAAACTGCCTATGTGGTTATGTGGAAGAAGATGGCTTGATGATCCAATGCGAGCTATGCCTGTGTTGGCAACACGGCATTTGCAATGGCATCAACAAGGAGTCTCAAGTACCCGATAAATATGTTTGCTATATCTGTCGTAATCCCCAAAGGAGCAGGGAATCTGTAAAGTTCAAACACGATCAAGATTGGCTGTATGAAGGCAAATTACCCACAGCCAATTTTCACTCACAAAACGTGGTTTTGGCCAATAAGAGAGCGGAATATCTCAAGCGTTCGCACACCCTTACTGGTAATCTGTTGGAGTTGAAGAACTACATGCATTCACTCAAAGTTAAAATCAATATAGCCAATAATAAATGCCACCCCAAACTATATTTATGGGCTAAGAAGTGGGATGAGGATGTGCTGGACGTAAAAAATGAAACTGATATTGAATCGAAGACCAGTATGTCACCTAACGCAAAGAAAATTAAGTCGGAACCCTCAACACCAGTACCCATTATACCACAACCCGAGGCACCCATAGATCCAGTGGAGTGCCAACAGCGTTTGCAGGAACATATTCGAATACAACAGCATTTGGTAATGCAACGTCTGAATGACATAGAAGCGGCCATAGATGttttggatCAAGAAGACGATTTACCCGATCTTCATGACGCTGATTTGGGTGCTACTAAAGACGCTTTGGCCGCCTTCATCAAAGAGCTGGATACATTCAAGAAAATTGGCAAATTAAATGCCTTGGAGCATACTAAACACGCTATTAAGAATCCCGTATCTtcgatttaa
Protein Sequence
MGRRCCIESCLSTSRLPEHHGVTYHSFPVDENTRAIWIRNTRIDARRNITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKVEANQIEEDLEFLSSTSSATAAAPTNLLSATASSVDEDTKATVAATVAQIMAQTAELNAQAALKAEKSFEAGDDAAAPDAGHGSPTGVKFEPVTTFNPGARLEAQDFDRIWHSARIVEVDNDDREVLIKFEKTGKVKLPIVGTEEWIPMNSSRLRQKISTKPILNFNVEDKCLARWSGPRKFPGTVKKVLPNDTYEILFDDGYIKNVRAIHMNKVMPADAEVVVENPAVEGSNAEVSPNASSTPIAGTPLLSPGIKRPASSGTPSSSGKKKRAPSSARKDWPLLDLSKLDLASLNLPEVPKDGEWACHWVNDQPIGREGFLLVGEHRKPTVVVEDWRLPPGWIKHMYQRSNVLGKWDVILVTPTGKRFRSKADLKTFLEEQGQVYNPDIYDFSIHRRRAKDINCYVYTPGYVPQQPVKPKPSFGLDTTMDSVTPPPLVLGTLPAVSVSSPYMETPTVEPLPPIELLTSSNLSADYKSVTQVEAEVPKQLLESAEVSSTPTPTTTPTVGLKEEIVVKSENPQLPSSIQEVEVKTEPMILETVPKIEDGYALIGSLKVQIIDNLFRCPEEGCFKNFRKENHLQIHVKHYHRNLVKLLGACPKMLDLAEKRTHPIGHDPNEPTPRNQIPNQQFFAKLHQQDLEQTRAHRRSVGAQKAQTEVSVDIKSELLDGQIKVETGEQLTSSPMQDISAIINSTNASSASILDSSYMSTAADDSMATASESALPDVPPLSKKSRFSPLKKPSGARKSNRQRTTKKYLTAAQATAGVVSQNASIAPVESSFSGVTDFEETRHSFNATPEIHKDSKRRRTNAAPPATTFSSAESPITADSGSSSLQPLSTTETESAAQYIKENGELIKIVSMRQEEIINCLCGYVEEDGLMIQCELCLCWQHGICNGINKESQVPDKYVCYICRNPQRSRESVKFKHDQDWLYEGKLPTANFHSQNVVLANKRAEYLKRSHTLTGNLLELKNYMHSLKVKINIANNKCHPKLYLWAKKWDEDVLDVKNETDIESKTSMSPNAKKIKSEPSTPVPIIPQPEAPIDPVECQQRLQEHIRIQQHLVMQRLNDIEAAIDVLDQEDDLPDLHDADLGATKDALAAFIKELDTFKKIGKLNALEHTKHAIKNPVSSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01175153;
90% Identity
iTF_01175153;
80% Identity
iTF_01175153;