Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.52 3.9e+03 -1.0 0.0 41 58 23 40 23 61 0.85

2 2 9.3e-16 6.9e-12 46.3 0.0 7 70 259 320 255 325 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.52	3.9e+03	-1.0	0.0	41	58	23	40	23	61	0.85
2	2	9.3e-16	6.9e-12	46.3	0.0	7	70	259	320	255	325	0.88

Coding Sequence: ATGTCGGAAGAAATGGCGGTGTCTGATAATGCTACAGGGGACGAAGCTAAAGTGAATAATGACGAGAAGGCCATGTCGACGGCTGCAGAAGTCGAGGAGGTTATTTCAGAACAGCCGAGCGAGGTTGCGGCTCCAGAGGTCCAGGAACCACCAGCTTTGCCTGAAGAGTCAGATCCAGCCCCAGCTCTAGAACCAGATGCAGAACCACTTCCAGGAGACCCTGCACCAGATACAACTGAAATTACAGAGGAACCAACAGTTAAAGAAGAACCCGCTGAAGAGGTTGAAGAACCACTTCCAGCAGAAACAGAGATTGAGAAAGAAATTAAAACCGAGTTGGAGACAAAACTAGAACCAATGGAATCAGAAGAACCCATGGTCCCTACAGAACCAGTTTGTGATGATGAAGTGGATGATAAGAGAGGGATAAAACGAAGGGCATCTGTTGCGTTTAGTGATGTTGATGATGAAGAGTTTAAAGGTTTTGATGAACACAAAGTGGAGGTTAAGGTGGAGGAATACGGTCGTGTTTTGGAACGTCTGGAGGCGGAGGTGTCCGCAGCCACCAAGGACTTCATCCCGGTGAGGCACGTGATGGCTACGCCCTCCGCTCCGGTCAGAGCCACGAAACGACCGCGCAAGGACACTGAAGGATCAAGGCCATCTTCAGCGTTATCATCAAGATCCGATGGCGACGGAGCCACTGATGCGAGCACGGGCGGCTCGCCGGcggcgcgcgggcggcgcgcgaCCACGGAGATGTCGTCGCCGCTGCTGCGCGTGCCGCTGGAGCGCGGCTGGAAGCGCGAGCTGGTGTTCCGCGCCGCGCTGGACGCGCACTCCCGCCGCAACGCAGATATCTACTACTACACGCCGCACGGGAAGAAGCTGCGCTCCAGCAGGGAGGTGGCGGAAAATCTTGCTGGCACTGGCCTCACATTAGAAAACTTCTCATTCTTCAAGGAGCCACTCGGCGTCGATGACCCAGAAAAGGAAATTATAAGGTGTGTACATTCTAATGGTACTAATTAA
Protein Sequence: MSEEMAVSDNATGDEAKVNNDEKAMSTAAEVEEVISEQPSEVAAPEVQEPPALPEESDPAPALEPDAEPLPGDPAPDTTEITEEPTVKEEPAEEVEEPLPAETEIEKEIKTELETKLEPMESEEPMVPTEPVCDDEVDDKRGIKRRASVAFSDVDDEEFKGFDEHKVEVKVEEYGRVLERLEAEVSAATKDFIPVRHVMATPSAPVRATKRPRKDTEGSRPSSALSSRSDGDGATDASTGGSPAARGRRATTEMSSPLLRVPLERGWKRELVFRAALDAHSRRNADIYYYTPHGKKLRSSREVAENLAGTGLTLENFSFFKEPLGVDDPEKEIIRCVHSNGTN*

Sequence clustering based on sequence similarity using MMseqs2