Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.3e-61 8.9e-58 194.0 0.1 2 128 22 150 21 151 0.96

2 2 0.41 2.8e+03 -1.6 0.0 11 30 311 330 307 332 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.3e-61	8.9e-58	194.0	0.1	2	128	22	150	21	151	0.96
2	2	0.41	2.8e+03	-1.6	0.0	11	30	311	330	307	332	0.86

Coding Sequence: ATGTTATATGCATTTGCGCAGGACATCGACGCGGTATACCAAAAGTACGTGGCGTGCATCCTGGAGGACGTGCGAGCCATCCACGGCAAAGAGATGGTGGCCACGGGCAGCCCGTCCGTTTTCTGTTCCGTTCTGCCCGGCCACTGGCGGTCCAACAAATCGCTACCGATACCGTTCAAAGTTGTCGTGTTGGACGAGGTGCCCGACGGTGCGGTCGTTGTCGTGCAAGCCGGCAACGACGAGAACCCATCGGCCGATATGCGAAACTACAGGGCCTTGTCGGCCACCGGTGTGGCAGTCTTCAACGATCTACGGTTCGTCGGCCGCAGTGGAAGAGgtaAACTGTTAACGCTCACCATCACAGTTCAGTGTAAAGATCAAGTAGTATTAGTAGCCAACTACGTGAAAGCTATTAAAATCACCGTCGACGGACCTAGACTTCCTCGGTCGAACCATAgagACGTGATCCACGGTTACGGTGGCATGTTCCCTATGCACGGGCCCCTGCCCCCTTACGGCATGATCATGGAGTACAAGCGGCTGTTGGAGGGCGCAGCGTTGCCTGGGTCGCTCAACTACCAGTACATAGCGGCCAATTACTTCCAACTTCACAATGCCATGGAAGCGTCGCAGATGTACTGCGACATGCCACCCCAGTCGGCGTTCAACTTTGCCGGCTACAACCACAGCATGCCGCCCACGCCTCCACACACCGAGGAGGAACCGTCGTCCATGATGGCCGGCGCGAAGGACGACTGCGGCCGCGGCATCGCGCCCTCGAAACGGCCCGCGGTCGAGTCGACGCCCTCCGTGGCCTGCACCGCGACACCGTTGTCGTCTACCGTCCCGGGCAGTGGCCGGCTCCACCAAGAGCCCAAACGGCCCAAGCGCGACACCGGGCCCACGCCGGACATAGACATCGTCAACGTGGCCGTCGTCCGGTCGTCCAGCCCGGAAGTGCTGAAACCCCGACAGGAGAAGATCTGGAGACCCTACGGCGCCACCGACGAATAG
Protein Sequence: MLYAFAQDIDAVYQKYVACILEDVRAIHGKEMVATGSPSVFCSVLPGHWRSNKSLPIPFKVVVLDEVPDGAVVVVQAGNDENPSADMRNYRALSATGVAVFNDLRFVGRSGRGKLLTLTITVQCKDQVVLVANYVKAIKITVDGPRLPRSNHRDVIHGYGGMFPMHGPLPPYGMIMEYKRLLEGAALPGSLNYQYIAANYFQLHNAMEASQMYCDMPPQSAFNFAGYNHSMPPTPPHTEEEPSSMMAGAKDDCGRGIAPSKRPAVESTPSVACTATPLSSTVPGSGRLHQEPKRPKRDTGPTPDIDIVNVAVVRSSSPEVLKPRQEKIWRPYGATDE

Sequence clustering based on sequence similarity using MMseqs2