Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00043 2.5 9.6 0.1 16 50 41 75 32 79 0.85

2 6 0.00054 3.2 9.3 0.1 23 45 76 98 73 102 0.89

3 6 0.0065 39 5.8 0.3 20 43 101 124 97 130 0.87

4 6 0.061 3.6e+02 2.7 0.1 21 44 130 153 127 161 0.86

5 6 0.0044 26 6.4 0.0 23 45 160 182 155 189 0.88

6 6 1.6 9.2e+03 -1.8 0.0 22 34 213 227 210 236 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00043	2.5	9.6	0.1	16	50	41	75	32	79	0.85
2	6	0.00054	3.2	9.3	0.1	23	45	76	98	73	102	0.89
3	6	0.0065	39	5.8	0.3	20	43	101	124	97	130	0.87
4	6	0.061	3.6e+02	2.7	0.1	21	44	130	153	127	161	0.86
5	6	0.0044	26	6.4	0.0	23	45	160	182	155	189	0.88
6	6	1.6	9.2e+03	-1.8	0.0	22	34	213	227	210	236	0.72

Coding Sequence: ATGGCCACTACGGAGGAATATGAAGAAGCTATGCCCATGAATGGTGCGGTACCAATGTATACATGCAAAAGATGTAATAAGatttttccctGTAAACGTGATCAACTTTTGCACAAAAAAGAGGTGCACTCCCAAACCAAGTCATCGTATGAATGCAAgatttgtgaaaaatatttttgtaacagtGGCAACTTAGAAAGGCATATGAAGGTTCACAATGATGTACGTCCCTTTGTATGTCGTATCTGTGGCAAAGCCTTTGCCCAGTCTGTTAATTTGAACCGCCACTATTCGGTACATAACGGGGAACGACCATATCAATGTACTTTCTGCACTAAATCGTTTACCCAACAGTCAAATATGCAACGCCATCAGCTAACACATACTGGCGAGAAACCTTTTCGTTGTAAACGTTGTGGTCGCTACTTTTCCCAGCGTGTTAACCTTAAAAAGCATATTATGGGTCATTTGAATACTAAACCATACACGTGTAAAGTTTGTCAAAAATCGTTTATACAATTGGGtaatttcaaaaaacatttaCAATCACATGTAAAGGATGGCGTAGACATTGATATGCAAGAAACTGTGGCTGAGGCTCAAGCAATAGCAAAACAAAATTTGGAAATGGCTGATGAGCAACCTGTAGGTTTTGAATGTGCCGTCTGTCGtacagtttttaataattttaccgaTTTTGAAATGCACGAGACTGAGTGCAATGATCAGGCTCAGGCCGCTATGGAACAGAAATATCATCCAGATCAACCACTACATGAAGTCATTGTCGAGGAAGTTGATGATAATATGGAAGAACATATAATACCCAATGAGAGTGGTGGTCATTTTGGCAGTTTTGCCCCATTGAAGTTTAGTGTCTCTCAATTGGATACTCATGAAATTATTATTGAAACCAGTCGATAA
Protein Sequence: MATTEEYEEAMPMNGAVPMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICEKYFCNSGNLERHMKVHNDVRPFVCRICGKAFAQSVNLNRHYSVHNGERPYQCTFCTKSFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCKVCQKSFIQLGNFKKHLQSHVKDGVDIDMQETVAEAQAIAKQNLEMADEQPVGFECAVCRTVFNNFTDFEMHETECNDQAQAAMEQKYHPDQPLHEVIVEEVDDNMEEHIIPNESGGHFGSFAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2