Basic Information

Insect: Pediculus humanus
Gene Symbol: -
Assembly: GCA_000006295.1
Location: NW:1549241-1556011[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.3e-11 4.2e-08 32.0 0.1 10 70 274 331 268 335 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.3e-11	4.2e-08	32.0	0.1	10	70	274	331	268	335	0.86

Sequence Information

Coding Sequence: atggaCACTATGGAAGAAAATGAAACAGTGGACTTAAATAGTGCAAATCAAATTTCTGCAGTCGAAAAggataatgaaaaagaagttgatgatgaaaatataaaaactaataTTCCTAGTGAAGATAAATCGGAATTATCGAAAGGTGAAGAAAATGCATTTGTTAGTGACATTAATAATTCTAATGTCAACAATGTTAGTGATAACGATTGTACAAAAGTGAATTCTGATGGAATGGAAGTTACATCTGAAGAAAATAATGAGGCTGCTGATACTGaaaattctaatttaaaaacagtAGATGAACCAGTAGAGAATTCagttaatgaattaaaaaccACGAaaaaagatgTTTCAGATGAGTCTGAAACTTTGGTTAAAATGGAAATTGATTctgaattaaatgaaaaaaattctgaagAAATTTCTGATATTAGGTCTTCTGAAAACTTTGTCGATGAAGAAAATAAGTGTAAAATCgatgaggaggaagaagatttcaaaggttttcctataataaatgatgaaataCAAAATCAGGATTTAGTTAAGAATTTGTCTCAAAAGGAAGAAGATGAATTACAAGAAATggaagtttttattaatagaaaaaatgaaacaaaacttTCCCCTCAggctaaaagaaaaagaaaggaaattgAAGAAAGCGATTTATCCAGTCATTGTAGTAGTCCTGCCTTAAGTGTAGCTTCTCAAATTAGTGTTTTaagttttacaaaaagaagTCGAACCGGTAGTCCTGCATCAAAAGGgtCGAGAAAATCATTAGTAGATTTATCAAATCCAAAATATTTAGTTCCATTTGATTTTGGTTGGAAAAGAGAAGTTGTCACTCGAGCTATAACTTCAAAAGAAGATGGAATCAGTAAagatgtttattattttcatccttCGGGAAAAAAACTAAGATCTCTGAGAGAGGTTTCAGAAAAATTGACGCCTGGTTTgacaatagaaaattttacattttacaaaGAGCCATTGGGAGCGGATCCACAATTTGAAACAATTAGAAATGCAAGAAGTCGAGGGTATTCTCCATTTGAAACGGCAACTCCGAAAAAAGTATTAGGCACGCCTTCGGTTATAAAAACACGTTCGGAAAAAGTTATTTCCGAAACTCCAGTTTTAAAAGACGCATCTTTAAAAGAACCTCCGTCACCTCCGAAGGATTCACCGAAAGCAACACCGttgaaaaatttcgttaaaactCCTAAAGAGCCAGCTGTGACGAAACCACCGCCttcgaagagagaaaaactcgTACTTAAATTTAACAAGGGAACTCCAAAGATCGCTTTAAAGAAATCACCAGCCGTAAACGGAGAACGAAAGTCTCCCAAATTAATGTTACCCAAACCTGAGGGACCCAAGCCTCATCCGAATGCGCCGTCGGGTCCACGAAGAAAAATAACACCTCGTAAAAAGCCTTTGAAAACATTAGGTAGTGCTaaggaagaaataaaaggaCCATTGAATAAATTAGAAAGTGGAGATTTGGAAATGGGTATGCTTCCGCCATTGTGGAGTCCCACAGCCGGGAGCACGAAAAGCTCAAGCAACGAATCATTATCGTGGAGTCACTTGGACGAAGAGAAaaGCATAAACGAAGAGGGAAGAATGGATCCTTGTACGATTAGGTGCACTAAGGCAATGGGATTAATCCCTACTCTTCAATGCAGCGTTTGTTTGTGCCTATATCATCCCGAATGCTGTGACATggcatcatcatcctcatacCGACAACTTTTGAAATACAATTGTAAAACGAAAGTCAGCGAGGTGAAATCGAGAAATTTAGTTAAACACATAACACCTGCTGTCGTTACAGATAAGAATCCTCCCATAATATCTCCAAAACCCATACATCCGGCTTTAACTCCTTCGCCGACAGCACAATCAAACGCCAACAATAATCGCATTCCTTCTTTGATTCGTCCCAAAATGCCGGTATCGAAATCTTCTATCGGCGGTGGAGGAGgaagtggaggaggaggaggaggagggggtggAGGTGGTGTATCCCCTTGGTTTCCTCCATCCAATTCCGTTTTTCGATCTCCTTCCGTTCTTCCGAAAAACTATCAAACCAAACCCGAAGACTCTGCTTCGCCACCTCAGGCTCTTGTAAATATGAACAACAAAAGGTATATTGTAGTACCCAAAAATAACGTTCTCTCGGTTGCTTCCAATCAAAATCAGTCACCGACAAAACTAGAGCCTTCTCAAAGTACAACCATAATTACTCCCACCCCGACTTCGACAATCATTCAAGGTCCACCTTTGCAAAATAATCCTTTCGTACAGCCCGCCGCGAATTCGCCAGGTGTCGTTCTCGTGCCTTTCATGTCGGGAGACAATACCGAAGTCAATCAACAACCTTTTCTGGTTGTTAATCCTTCACCCGGCTCGTCGGTCATACCGAATTCTAGTCAAGCTGATCTCCCAACCGAAAGCGAAACAACCGATCACTTTCAAAAGCAGGCGGTCAAGGCACCCAATAAAAGACCATCATCAGATGGAGGCAACGAATCCATGCAAAAATTCATGAGAAATATCTGCATTGGttATTCTGCATTACTCAATGTATTCCAGTACCTTAAAGTTCAAGAATTGTTGAGAGCGGGTCGCGTTTGTCGATTATGGAGAGATTTGGCAAGTCATTCATCGctgtGGCGAACcgttcgaatgaaaaattcgCAAGTTTCCGATTGGAAAGGTTTCACGGATTCCCTTTCCCGTCACGGTACGAAACACCTCGACCTTCGTAAAATGTTAATGTCACTCGACGACGCTCAAGAAATGTGGGGACTCTTTGCTAAACACATATCCGGAGTGAAATGTTTGGAAAGATTGGACATGTGCCGGTGTTCCGTGAACATCGTCGTACAAGTCATGGAAGCATGTCCgcaattgtttgttttcaacgCTCAACAAATGATCGGTTCCAAAGACGaaatattaaatcaaaaattatcgTTGGAAAGTttgtcgaaaatgaaaaatttaaaagaattgagattgaaaagtttttgcgGACTTCATTTGACGGATTCTTTGAAATCGTTGACGGACCTATCGGACACTTTGACGACGCTGTCTTTGACGTCGGTGAAAAATTTAGGGACCTGCAAATTACAATACATTGGAATGCTGCAAAATTTGGAAGCTTTAGAATTGGGAGAATGTAACGATTTGCCGGAAACATTTCCAAACGAAGTCATAGCCAAGCTCACGACATTGAAAAGGTTCGGGTTCGATGAAACAGGAATGAaacaaaatcgaatcgaaacGATAAGGTTGGAAAAAGGACCGTGGAATTGTTCGACGAACGAAATGCTTTTTCAAATGAGCAAACTCAAAGAATTGATACAATTGGAATTGATCAATTTCGATGTGAGACCTGGTTTCGATAAAGCACTTGCCTCTTGTACAAACATTAAACGCCTTTTATTAATACCGACATACGTCACTCAGtCAGCGACAACGAACAACATTATTTTATCTGGGACATATAAGCTGTATAAATCATTGACTCTATTCGTTTGGGTCGTCACGATGGAATTGTTAAAAGTCACGGAGCTTTTCGTGGATCAGTGCGAAGGAAAGGGATCTAAAAAAAGCGGGGGCAACAGCGTTCCTGTATTGAAGCCAGTGCCATTGCCCGCCGTCACGCAAAAAGATGgtgaaaattcgaaaaaggaGGATGAGGAGGGAGGAGTTAAAAATCCCATGCCGATAACGATAATACCAATCGATGAATTATTCGTCATGCTGACGGAAGGTTTGCCAACGACGAAaaataataagtttaaaatttag
Protein Sequence: MDTMEENETVDLNSANQISAVEKDNEKEVDDENIKTNIPSEDKSELSKGEENAFVSDINNSNVNNVSDNDCTKVNSDGMEVTSEENNEAADTENSNLKTVDEPVENSVNELKTTKKDVSDESETLVKMEIDSELNEKNSEEISDIRSSENFVDEENKCKIDEEEEDFKGFPIINDEIQNQDLVKNLSQKEEDELQEMEVFINRKNETKLSPQAKRKRKEIEESDLSSHCSSPALSVASQISVLSFTKRSRTGSPASKGSRKSLVDLSNPKYLVPFDFGWKREVVTRAITSKEDGISKDVYYFHPSGKKLRSLREVSEKLTPGLTIENFTFYKEPLGADPQFETIRNARSRGYSPFETATPKKVLGTPSVIKTRSEKVISETPVLKDASLKEPPSPPKDSPKATPLKNFVKTPKEPAVTKPPPSKREKLVLKFNKGTPKIALKKSPAVNGERKSPKLMLPKPEGPKPHPNAPSGPRRKITPRKKPLKTLGSAKEEIKGPLNKLESGDLEMGMLPPLWSPTAGSTKSSSNESLSWSHLDEEKSINEEGRMDPCTIRCTKAMGLIPTLQCSVCLCLYHPECCDMASSSSYRQLLKYNCKTKVSEVKSRNLVKHITPAVVTDKNPPIISPKPIHPALTPSPTAQSNANNNRIPSLIRPKMPVSKSSIGGGGGSGGGGGGGGGGGVSPWFPPSNSVFRSPSVLPKNYQTKPEDSASPPQALVNMNNKRYIVVPKNNVLSVASNQNQSPTKLEPSQSTTIITPTPTSTIIQGPPLQNNPFVQPAANSPGVVLVPFMSGDNTEVNQQPFLVVNPSPGSSVIPNSSQADLPTESETTDHFQKQAVKAPNKRPSSDGGNESMQKFMRNICIGYSALLNVFQYLKVQELLRAGRVCRLWRDLASHSSLWRTVRMKNSQVSDWKGFTDSLSRHGTKHLDLRKMLMSLDDAQEMWGLFAKHISGVKCLERLDMCRCSVNIVVQVMEACPQLFVFNAQQMIGSKDEILNQKLSLESLSKMKNLKELRLKSFCGLHLTDSLKSLTDLSDTLTTLSLTSVKNLGTCKLQYIGMLQNLEALELGECNDLPETFPNEVIAKLTTLKRFGFDETGMKQNRIETIRLEKGPWNCSTNEMLFQMSKLKELIQLELINFDVRPGFDKALASCTNIKRLLLIPTYVTQSATTNNIILSGTYKLYKSLTLFVWVVTMELLKVTELFVDQCEGKGSKKSGGNSVPVLKPVPLPAVTQKDGENSKKEDEEGGVKNPMPITIIPIDELFVMLTEGLPTTKNNKFKI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -