Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.075 2.4e+02 2.2 0.0 26 44 69 87 63 93 0.84

2 6 0.0018 5.7 7.4 0.0 23 49 94 120 89 125 0.88

3 6 0.6 1.9e+03 -0.6 0.1 27 46 130 149 126 151 0.88

4 6 0.12 3.7e+02 1.6 0.0 27 46 161 180 157 186 0.87

5 6 0.00086 2.7 8.5 0.4 26 45 188 207 182 228 0.91

6 6 0.00012 0.37 11.2 0.0 22 48 240 266 236 269 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.075	2.4e+02	2.2	0.0	26	44	69	87	63	93	0.84
2	6	0.0018	5.7	7.4	0.0	23	49	94	120	89	125	0.88
3	6	0.6	1.9e+03	-0.6	0.1	27	46	130	149	126	151	0.88
4	6	0.12	3.7e+02	1.6	0.0	27	46	161	180	157	186	0.87
5	6	0.00086	2.7	8.5	0.4	26	45	188	207	182	228	0.91
6	6	0.00012	0.37	11.2	0.0	22	48	240	266	236	269	0.91

Coding Sequence: ATGTTAACTCAAAAAACCAGCAAAGCTTTGGAGAAGTTAATATCAGATTTGGACATCTCAGAAAATGACGATGACGAATTCAACTCGACAGAAGATTTCATAAAAGAAAGAGgGATGAAATATGAATGTATATACTGTTCTAGAGGATTCGAAATGAAATGCAGATATGATTATCACATGAAAATACATGGTTCTTCTAATGAACAATGCCCAGTTTGTAAAAagatgtttaaaaataaacgttACGTTACAGTTCATATGAAAACACATACagatacacaaaaatatacgTGCACTAAATGctttaaagtgtattcatcAAAGTCTAATCTAGGAAAACATATGCGATTTAGTCATGAGCCTAAAAAGAAATCTAAACTATTTTTATGTCATATTTGTTCTAAAGAATTTTCAACATCAACACATTTAAACAACCATCTTCAAATTCATGAACCAAAAATTATAGATGGCACTTTTATGTGtgaaatttgtgaaaaaatgtttacaacaaaaattaatttaaataaacatttagtTATTCAtaataccaaaaatatattctctTGTACAATTTGTCAAAAACAATTTAGACAATCAAAACATCTGAAGGAACATATTATTGTTCACACACaggaaaaaacatttttttgcaaACTTTGTAATAAATGTTTTGCTAGACCTAATCAACTTAAaGTTCacacaaaaattcatttaaatgaaaaagatgTATCTTGTCCGTTATGCTCACGTAAATTTACACAACTGGGAAATATGAAAAGGCATTTGTCGATTGtacataaaaatgaaaaaattaaaaaattaaattaa
Protein Sequence: MLTQKTSKALEKLISDLDISENDDDEFNSTEDFIKERGMKYECIYCSRGFEMKCRYDYHMKIHGSSNEQCPVCKKMFKNKRYVTVHMKTHTDTQKYTCTKCFKVYSSKSNLGKHMRFSHEPKKKSKLFLCHICSKEFSTSTHLNNHLQIHEPKIIDGTFMCEICEKMFTTKINLNKHLVIHNTKNIFSCTICQKQFRQSKHLKEHIIVHTQEKTFFCKLCNKCFARPNQLKVHTKIHLNEKDVSCPLCSRKFTQLGNMKRHLSIVHKNEKIKKLN

Sequence clustering based on sequence similarity using MMseqs2