Prec026886.1
Basic Information
- Insect
- Pasiphila rectangulata
- Gene Symbol
- tc1a
- Assembly
- GCA_963082625.1
- Location
- OY720254.1:5998787-5999329[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.8e-10 4.5e-07 31.0 0.6 16 104 5 92 2 109 0.88
Sequence Information
- Coding Sequence
- atgggaaaagtgcgcgaaattagcactgaaactcgttctgccatagttgttttacacggcgaaggcaaatctgaacgtgcgattgcctctcaacttaagttgtcgaagacttgtgttcataacgcaataacccgatacaaggagactggcagtaatcaagatcgttcgcgattggggagaccgagagctaccacttctagcgaggataatttcatcgtcgttaccagcaagcggaatagacgcctaaccgcaccagaaatccgcgcagaagtgaacaaatcccgatcagaacctgtgtcattgactacagtaaaaagacgattgagagatgctaagttatttggtcgcgtcgccgttcgaaaaccactactaaggccacaaaacaaaaagaaacggatgcagtgggcccttacccatcgagactggactgaagaagactttaaagaagttctttggacagatgaatccaagttcgaaatatttggttcaaaacgacgaatttttgttcgacgtaccgccgaggaaaagatgatgccagattga
- Protein Sequence
- MGKVREISTETRSAIVVLHGEGKSERAIASQLKLSKTCVHNAITRYKETGSNQDRSRLGRPRATTSSEDNFIVVTSKRNRRLTAPEIRAEVNKSRSEPVSLTTVKRRLRDAKLFGRVAVRKPLLRPQNKKKRMQWALTHRDWTEEDFKEVLWTDESKFEIFGSKRRIFVRRTAEEKMMPD
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00649069; iTF_01182841; iTF_00822987; iTF_01078178; iTF_00667437; iTF_01161327; iTF_01246874; iTF_01161341; iTF_00822988; iTF_00822989; iTF_00667442; iTF_01425906; iTF_00711833; iTF_01361594; iTF_01361595; iTF_00290668; iTF_01361593; iTF_01361596;
- 90% Identity
- iTF_01161326;
- 80% Identity
- -