Basic Information

Gene Symbol
egg
Assembly
GCA_018244795.1
Location
DWME01028967.1:1493-3368[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.17 1.2e+03 -0.2 0.0 29 38 62 71 31 73 0.70
2 2 1.4e-13 9.8e-10 38.5 0.0 5 75 104 167 100 169 0.90

Sequence Information

Coding Sequence
atggcacaaaaaaggttgggaaacactgctctagAGATTGGtatctttaataaattcttCTGGTCGCTGTTACAGAACACAGATGTGAATCGTCGCGCGGTGGCCAAAAAGTCCACCAGCGTGGTGTCGAGCGCGTCCGCCGCCGCCTCCCCCGCCGTCCCGCCCGCGCAGAACCTGGACAACATCACCAGCAGAGTTGTGTACTACACACCAAAGCATTCGGTGAGACCTCGCAGACTCGTGCCCCACAACTGCGGTCCCCAGTGCAACAGGACCGATGTGTTGCCGCTGCACGAGCTTAAAACGTACAATCCACTGGCGAAACCGTTGCTCAGCGGATGGGAGAGGCAGATCGTGCGGTACAAGGGGCAGAAGGGCGTGGCGTACCGCGCGCCGtgcgggcggcgcgtgcgcgaCCAGCGCGAGCTGCACCGGCTGCTGCGCGCCACCCGCGCCGACCTCTCGCTCGACCTCTTCGACTTCCAGCCGCACACGCACTGCCTCGCCGAGTTCGTGCTCAACAAGTGCCTCATCATGAAGAAGGAGAACCATATAGATGTTTTACTGCCTGTCAATGTTCAGCCTGATCTAAGGAGCCGGTTCGaaggaacaaaaaatataaccgaATTCAAACGGACAAATAACGACAGCGATCTTATTGAAGGTGATCTCACTAATTAA
Protein Sequence
MAQKRLGNTALEIGIFNKFFWSLLQNTDVNRRAVAKKSTSVVSSASAAASPAVPPAQNLDNITSRVVYYTPKHSVRPRRLVPHNCGPQCNRTDVLPLHELKTYNPLAKPLLSGWERQIVRYKGQKGVAYRAPCGRRVRDQRELHRLLRATRADLSLDLFDFQPHTHCLAEFVLNKCLIMKKENHIDVLLPVNVQPDLRSRFEGTKNITEFKRTNNDSDLIEGDLTN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-