Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.5e-09 3.6e-05 24.0 0.1 40 65 1 26 1 26 0.96

2 3 0.46 2.6e+03 -1.1 0.0 11 29 32 49 31 51 0.78

3 3 3.8e-16 2.1e-12 47.2 0.1 3 63 63 150 61 152 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.5e-09	3.6e-05	24.0	0.1	40	65	1	26	1	26	0.96
2	3	0.46	2.6e+03	-1.1	0.0	11	29	32	49	31	51	0.78
3	3	3.8e-16	2.1e-12	47.2	0.1	3	63	63	150	61	152	0.88

Coding Sequence: ATGTATGATATCATCAATATTTTGGAGGCCATGCAATGTGCCGTTCATAAAAGGAAAAACACGTATCTATGGCATGGAGGATCAAGACTGAACTCATTCTTGAAACTGCTGAAGAAACAAGGCGAGACCTTGAGGCTGTCTGAGGCTCTACGTGGCAGAGCTCCTAAACCACCAGCACCAAAATATAAAGCACTTGGTGTGTTGGCACAGAGGTTTCTGATGCTTTTCTTAGTGGAGCCACCAAACACCTTGATTAATCTTGAAATGGCAGTGCGAGTACTTATTGACACCAGCAACAAGAACAAAACTGTTCTCTCTCCCGAGCAACTCGACCGCCAACACAAGTCCAAAGTGAGGAGGCTGTACGACATTgccaatgtttttatttccattgGTCTCATAGAAAAAGTATgtggtaatttaatattaaaaaaacctgtattcaaatatgtagggccttataaaatgaaaaagtctGATAGAATTATTTCAATGACCACTCCATCACCGGTGACATCACTCGCTATACCAAATACTCAGCATAGAGTGACACCGTGTCATGTATTCGCTGGCAGATCAAAACGAAAATTGGAGTTTACAACACCAAATAACAGTGTCGAACTGAAGCTAGGCATAACTACCCCACCACACACACCATCACACAAATGGGATGAGATCCTACTTGTGGCCGACATGGAACTGACTAGGATTAACAATGGTGCCttattgtga
Protein Sequence: MYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKLLKKQGETLRLSEALRGRAPKPPAPKYKALGVLAQRFLMLFLVEPPNTLINLEMAVRVLIDTSNKNKTVLSPEQLDRQHKSKVRRLYDIANVFISIGLIEKVCGNLILKKPVFKYVGPYKMKKSDRIISMTTPSPVTSLAIPNTQHRVTPCHVFAGRSKRKLEFTTPNNSVELKLGITTPPHTPSHKWDEILLVADMELTRINNGALL

Sequence clustering based on sequence similarity using MMseqs2