Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.5e-05 0.54 8.9 0.4 44 116 9 89 5 114 0.56

2 3 1.7e-08 0.0002 20.2 21.9 345 512 112 276 97 277 0.58

3 3 0.16 1.9e+03 -2.8 0.4 467 475 311 319 281 328 0.67

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.5e-05	0.54	8.9	0.4	44	116	9	89	5	114	0.56
2	3	1.7e-08	0.0002	20.2	21.9	345	512	112	276	97	277	0.58
3	3	0.16	1.9e+03	-2.8	0.4	467	475	311	319	281	328	0.67

Coding Sequence: ATGTATGACGTTGTGGGCAACCGGGACCGCGTGAGCCAGCAGATCCAGATCAAACTCGGCGACTACCAGATCGCACAGACGCTGCTCGACGACCCCAGCAAATCCATCGGCATCTGTGCTGAGCCCCCCAGCCCCGCGCCATGTCACCCGTCCCGGCGGGAGAGCGAGTTCAAGAAGCCGGCCCACGCTCCCCAGAACGGACGAGTTCACCATCGACCGCCCTACCCCTACAACAAGAGCGAAAGCCTGAGTTCCACGGGCGCGCCCGCTCACCGCCCTCCCCCGCTGCGGATATCCAATGGCTTCCAACCACCGagTTCAAGTATCGATAGCAGTCAATTGCCAAtagaaagtattttaaagGAGATGAAGTCACTACCTACCCCATTGTCTGTGATAGCGGCCACGCCGAGGAAAGAACTCGAAAACAAGTTCATTTTCAACCCCTATACTAATAAGGTGCAAGAGAACCCTCAGCTAGCGAACAACGATCTCAAAACACCTGTAACGAAGCCTGgtCTCGATAACCGGATATCTAATTCGAGGAGTTCAGTTTCGccTCAACATGTGAACGCGCGTGGTTGCAGTGAGGTGGTGAATAAGGATCTCGGGCTTTCGGAAAGCGATGACGAGGTCGCCGTCACCACGGCAAGGCTTGGACCTATCATATCTCCTATCGGCTCCGGCGGCAGTCCCAGTTCCGGCAGTGAATCCTCCCCGTCCGATTCCGAGTCGGAATCATCCTCTAGTGAGTCGACAGCGGCTTGCAcggccgcgcccgccgcgcagCCCGCGGCCGAGCGACCCTCATGGAGTCTCAGTAACTTCGCCCCTCCCTCACAGCATCCGCCGCAGCACTACGACGCCGGCAAGGATCTCCGGCACGCACTCGAAGATGTCAAAGGCAAACCGAGTCCAATTTCGGAGTTGTCGGACTCTGAGACTTCGTCGCCGTCGCCCGGCGCGTCGCGGCGTCGGCGCTCTACACAGCTGTACTAA
Protein Sequence: MYDVVGNRDRVSQQIQIKLGDYQIAQTLLDDPSKSIGICAEPPSPAPCHPSRRESEFKKPAHAPQNGRVHHRPPYPYNKSESLSSTGAPAHRPPPLRISNGFQPPSSSIDSSQLPIESILKEMKSLPTPLSVIAATPRKELENKFIFNPYTNKVQENPQLANNDLKTPVTKPGLDNRISNSRSSVSPQHVNARGCSEVVNKDLGLSESDDEVAVTTARLGPIISPIGSGGSPSSGSESSPSDSESESSSSESTAACTAAPAAQPAAERPSWSLSNFAPPSQHPPQHYDAGKDLRHALEDVKGKPSPISELSDSETSSPSPGASRRRRSTQLY

Sequence clustering based on sequence similarity using MMseqs2