Basic Information

Gene Symbol
MBD2
Assembly
GCA_018231625.1
Location
DVQH01008971.1:2857-3666[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-20 8.6e-17 62.0 0.0 9 73 4 62 1 65 0.93
2 2 0.49 2.9e+03 -0.5 0.1 7 23 94 110 83 150 0.63

Sequence Information

Coding Sequence
ATGACCACCTTGGCCCTACCGCCCGGATGGCGTCGCGAGGAGGTCAAGCGAACCAACGGGCTATCGGGCAAGATTGATGTCTATTACATCTCACCCAAAGGAAGGCGAATCAAGTCAAAGATTGAACTGGCCAAGTATCTCGGGCCAAACGTCGATCTCTCCGCCTTTGACTTTCGCACGGGCAAGATTAACCCTTTGCTGTACCGCAAGGACAACAAGCCTACTAGTGGACTGGGCGATTTGAAAAGTCTCAAATATGACACCTCACTAACGTCACCGGCCAGACAGGTGTTGCCACTTGGCAAAAAACGTGTGGTGCTGGTTAAATCCCAGCCCGACTCGGTGGTCTACGGTCCCGAGAGACTCAAGGAGTTACGTAAAAAGTTTCCCACTCTGAACGAGAACGCCGAGAAGCCGTACCAGTTGTTCTGGCAGAAGCGACTGGAGGGTGTGCGACCACACTACCTGGAGCAATCCGAGTCGGATCTCGGTGACATGTTTGAGTTGCCCACCGAGATGCGAGCCTTCAGTGCGTTGCTTTCCCAGAAGGACACCTTGATGCGCAGTGTTGCGGCCGCACTGCAGCTCAACTCGAACCACGCGGTTCGGGGCCAGGAGAAGAATGTGTTGGCACGAGGCCGGAAAGATCCGTTCCTCGATGAGAACTGCCAACGCAACCCGGTGGCCTTTGTCAACCCGAACCAACCACTGATCCAGCCGATCACGATCAGTGAGGAGGACATCCGCCGGCAGGAGGAGGTGGTGCGCAAAGCAAGGCTCAACCTTCAAGCCGCCATCGCTGATCTCTAA
Protein Sequence
MTTLALPPGWRREEVKRTNGLSGKIDVYYISPKGRRIKSKIELAKYLGPNVDLSAFDFRTGKINPLLYRKDNKPTSGLGDLKSLKYDTSLTSPARQVLPLGKKRVVLVKSQPDSVVYGPERLKELRKKFPTLNENAEKPYQLFWQKRLEGVRPHYLEQSESDLGDMFELPTEMRAFSALLSQKDTLMRSVAAALQLNSNHAVRGQEKNVLARGRKDPFLDENCQRNPVAFVNPNQPLIQPITISEEDIRRQEEVVRKARLNLQAAIADL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-