Basic Information

Gene Symbol
-
Assembly
GCA_026546675.1
Location
JAOCNA010000021.1:966401-969739[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00054 0.097 14.4 1.7 1 23 149 171 149 171 0.98
2 10 0.073 13 7.7 0.7 3 23 196 217 194 217 0.94
3 10 0.0002 0.036 15.7 0.7 2 23 239 260 238 260 0.95
4 10 0.00013 0.022 16.4 0.5 1 23 264 286 264 286 0.98
5 10 0.0023 0.41 12.4 0.3 1 23 293 316 293 316 0.95
6 10 4.6 8.2e+02 2.0 0.4 3 23 324 345 322 345 0.83
7 10 2.5e-05 0.0044 18.6 1.2 1 23 351 374 351 374 0.97
8 10 7.7e-05 0.014 17.1 1.4 1 23 380 402 380 402 0.98
9 10 6.6e-06 0.0012 20.4 0.9 1 23 408 430 408 430 0.99
10 10 5.7e-06 0.001 20.6 3.6 1 23 436 458 436 459 0.96

Sequence Information

Coding Sequence
ATGGCAGTAACGATAAGTACTAAGAATAAAAAAGGACCGATAATCGATCCAGCACTATGTCGATGTTGTCGTTCAATAAAAAAATGCCGTATCCTGTCGGCGGAATACGAATGGATGGGAAATAAAGAAGTGTATTCAGATATGCTTATGGATTGCTTTGGATTACTTCTGTCACACCTAGATGGTGATAATAAGGAGATTGGAATCTGTGCAACCTGTGTGTGCAGATTACGTGAGGCTTGCAGCTTTAGACGACAAGTTCTGCAGTCGGAAGAGGTGTTCATGAAGGCTAAGCTTGAGGGAAATAAAGATGGAATACAGGATACAACATTAATTCCGGGTAAAGTGAAAAAAACCTTTGACCATGAagaaatggcttatatcaacacagtaactatagttcacaattcctatgtctgtccgttccacaacaaagttagtaattactactgttattattgcaaagatcaattcacaaaccccaatgaattacgcgaacacacgatgacacacgaaccaaaagcaatgttcgaaagcatgatggaacataaaaagataccgaaaatcgatattacaagaatcgattgtcgattatgtcatgaaaaaatcgataatctagaaacattaaaaaaacacctcactattgtccatggcttaaagttgcatccaatcacaaacgagttcttaaaattccgtttgacgttaaataacttaacttgtacagaatgtaagagttcttttccatattttgattcattaaaaaaacacatggctgaacatttcggtacatttatttgtgatatatgtggtgcttgctttttagagcaggcttccttaagaactcatataaaaacacattataaaatagatatgtgctttccttgtgagatctgtggtaagaatcttaaatctaaatatagcagatatttacatgtagcgactgttcatgagaaaaaaccaacagttaattgctacaaatgtgatgcagcgtttctctcacatgcgttaagaaataaacatttaatcgaagtgcacggtgataagagaacatttccttgcaaattgtgtgacaaagtttacaatagaagaaaaactttaatggaacataatcgaagaattcatttgaaagtatatagacatcaatgtgacttgtgtgaccagagattttatttaccatcgagattgaaagagcatatggcaacacacactggagagaggaattttcgttgtgaattctgtgacaaaggttacccaagattaaagtccttgcaggaacatttgcgttcgcatactaatgacagacgttacaaatgtgatatgtgcaattcaactttcacacaaagtgctagtcttaaaaatcatttgaagagtcaccatcaaggatatgaaatggaagCCAGTTTTAATTAA
Protein Sequence
MAVTISTKNKKGPIIDPALCRCCRSIKKCRILSAEYEWMGNKEVYSDMLMDCFGLLLSHLDGDNKEIGICATCVCRLREACSFRRQVLQSEEVFMKAKLEGNKDGIQDTTLIPGKVKKTFDHEEMAYINTVTIVHNSYVCPFHNKVSNYYCYYCKDQFTNPNELREHTMTHEPKAMFESMMEHKKIPKIDITRIDCRLCHEKIDNLETLKKHLTIVHGLKLHPITNEFLKFRLTLNNLTCTECKSSFPYFDSLKKHMAEHFGTFICDICGACFLEQASLRTHIKTHYKIDMCFPCEICGKNLKSKYSRYLHVATVHEKKPTVNCYKCDAAFLSHALRNKHLIEVHGDKRTFPCKLCDKVYNRRKTLMEHNRRIHLKVYRHQCDLCDQRFYLPSRLKEHMATHTGERNFRCEFCDKGYPRLKSLQEHLRSHTNDRRYKCDMCNSTFTQSASLKNHLKSHHQGYEMEASFN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01147579; iTF_01145454;
90% Identity
-
80% Identity
-