Basic Information

Insect: Papilio glaucus
Gene Symbol: HMGB6
Assembly: None
Location: scaffold:245018-248773[+]

Transcription Factor Domain

TF Family: HMG
Domain: HMG_box domain
PFAM: PF00505
TF Group: Other Alpha-Helix Group
Description: High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8.9e-15 6.3e-12 45.6 2.6 1 68 51 118 51 119 0.97

2 3 9.6 6.8e+03 -2.6 0.5 53 63 138 148 128 152 0.59

3 3 4e-08 2.9e-05 24.2 10.6 1 68 156 219 156 220 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8.9e-15	6.3e-12	45.6	2.6	1	68	51	118	51	119	0.97
2	3	9.6	6.8e+03	-2.6	0.5	53	63	138	148	128	152	0.59
3	3	4e-08	2.9e-05	24.2	10.6	1	68	156	219	156	220	0.92

Sequence Information

Coding Sequence: ATGTCTTCAATTAGTCAGATCTGTCGTCTGAGTAATTACGTTGTAGGAAGTTATAAAACAGTTCTACACACAAGAACAAATTGGTTAAACGGTATACAAGTATGTACTTACACTAAGAAATCAGCTGAAGAGAAATTGGGGATAGAAAAACCTAAAAGGCCATTGACACCTTTTTTTAAATTTATGACACAAATGAGGCCAGCACTACTAGCTAAGAATCCTGGAATAACATCTAAAGAGACGATTACTTGGATTTCAAAACATTGGCAACAACTGGATAGTGAGACAAAAGCACAAATGGTTAAAGAATATGAAAAAGACCAGGAAGATTATAAAAAGATTAAGGAATTATATGAAGCTTCACTGACTGAGCAACAAAAAGATGACATAAAGAGAGTCAAAGCGGAAATGGCTGCAGCTAAGGAGAAACGAAAAATAAAAGCTGAATTAAAAGAGATGGGGAAACCAAAGAAACCAATGTCCTCATACTTCCTTTTCTCACAAACGAAAAAAGAACTATTTCAAGGTAAAAGTATGAAGGAATACCAAGAACAGATAAAAAGAGAGTGGTTAAAATTGTCCGAAAATGAAAGAGTAAAATATGAAAAACAAGCACAAGTTCTCATGGATAAATACAAAAAAGAACTAGAAGCTTGGGAATTGAAGATGATTGCCATAGGACGTACAGATTTAGTACGCCAGAAGCCAGCGCGACAACCGAAAAAAGCGAGAGGTGTAAAGGAACAATAG
Protein Sequence: MSSISQICRLSNYVVGSYKTVLHTRTNWLNGIQVCTYTKKSAEEKLGIEKPKRPLTPFFKFMTQMRPALLAKNPGITSKETITWISKHWQQLDSETKAQMVKEYEKDQEDYKKIKELYEASLTEQQKDDIKRVKAEMAAAKEKRKIKAELKEMGKPKKPMSSYFLFSQTKKELFQGKSMKEYQEQIKREWLKLSENERVKYEKQAQVLMDKYKKELEAWELKMIAIGRTDLVRQKPARQPKKARGVKEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00957942;
90% Identity: iTF_01141667;
80% Identity: -