HMG
- Domain
- HMG_box domain
- Group
- Other Alpha-Helix Group
- PFAM
- PF00505
- Desciption
- High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
- Rederence
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- The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Harley VR, Clarkson MJ, Argentaro A. Endocr. Rev. 24, 466-87, (2003).
- Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Labbe E, Letamendia A, Attisano L. Proc. Natl. Acad. Sci. U.S.A. 97, 8358-63, (2000).
- The modulation of the biological activities of mitochondrial histone Abf2p by yeast PKA and its possible role in the regulation of mitochondrial DNA content during glucose repression. Cho JH, Lee YK, Chae CB. Biochim. Biophys. Acta 1522, 175-86, (2001).
- Cloning and characterization of the mating type (MAT) locus from Ascochyta rabiei (teleomorph: Didymella rabiei) and a MAT phylogeny of legume-associated Ascochyta spp. Barve MP, Arie T, Salimath SS, Muehlbauer FJ, Peever TL. Fungal Genet. Biol. 39, 151-67, (2003).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000324 | Abrostola tripartita | Atri006273.1 | sem-2 |
| iTF_00000337 | Abrostola tripartita | Atri011060.1 | Sox15 |
| iTF_00000317 | Abrostola tripartita | Atri015566.1 | Dsp1 |
| iTF_00000318 | Abrostola tripartita | Atri010410.1 | sox2 |
| iTF_00000319 | Abrostola tripartita | Atri009651.1 | sox21b |
| iTF_00000320 | Abrostola tripartita | Atri009656.1 | D |
| iTF_00000321 | Abrostola tripartita | Atri019338.1 | SOX5 |
| iTF_00000322 | Abrostola tripartita | Atri016807.1 | sox9-b |
| iTF_00000323 | Abrostola tripartita | Atri009652.1 | sox-2 |
| iTF_00000325 | Abrostola tripartita | Atri008811.1 | pan |
| iTF_00000326 | Abrostola tripartita | Atri012823.1 | HmgD |
| iTF_00000327 | Abrostola tripartita | Atri012824.1 | Ssrp |
| iTF_00000328 | Abrostola tripartita | Atri005747.1 | HmgD |
| iTF_00000329 | Abrostola tripartita | Atri014267.1 | CIC |
| iTF_00000330 | Abrostola tripartita | Atri019227.1 | Smarce1 |
| iTF_00000331 | Abrostola tripartita | Atri012730.1 | HMG20A |
| iTF_00000332 | Abrostola tripartita | Atri002820.1 | TOX4 |
| iTF_00000333 | Abrostola tripartita | Atri001766.1 | BBX |
| iTF_00000334 | Abrostola tripartita | Atri013267.1 | TFPT |
| iTF_00000335 | Abrostola tripartita | Atri005514.1 | - |
| iTF_00000336 | Abrostola tripartita | Atri009664.1 | D |
| iTF_00000338 | Abrostola tripartita | Atri002092.1 | PBRM1 |
| iTF_00000339 | Abrostola tripartita | Atri007126.1 | hmgxb4 |
| iTF_00000340 | Abrostola tripartita | Atri009666.1 | SOX21 |
| iTF_00000341 | Abrostola tripartita | Atri011062.1 | Sox15 |