Basic Information

Gene Symbol
e2f7
Assembly
GCA_013186455.1
Location
QDHC01003372.1:1131480-1133920[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.3e-15 6.3e-12 45.1 0.2 23 65 2 44 1 44 0.96
2 3 1.8 8.7e+03 -3.4 0.0 12 29 51 67 49 68 0.64
3 3 5.9e-17 2.8e-13 49.4 0.1 1 64 79 169 79 170 0.90

Sequence Information

Coding Sequence
ATGAAAATTCAATTAGACAGCACTGCGGCCAGGTTGGGAGTAGGAAAACGCAGAATGTATGacataatcaatattttagaaGCGATGAAGTATGCAGTccatgaaaagaaaaatacatatttgtgGCATGGCGAGGCTGGCCTTAGTTCCTTtctaaaaattcttaaaaaacaaGGGGAAAGTCTACGCTTATCCGAGGCTTTGAGAGGGAGAGCGCCCAAGCCTCCGCCACCAAAACACAAAACACTGGGAATACTGGCCAAAAGAttcttaatgttatttttagttgaACCACCAAATACTCTAATAAATTTAGAGATGGCTGTGAAGGTACTAATAGACACctcaaatagaaataaaactgaTCTCTCTCCAGAGCAGCTGGACCGCCAACACAAGTCTAAAGTGCGAAGGCTCTACGATATTGCcaacatatttatatcaattggTCTCATTGAAAAGGTTTCCggtaatttgatattaaagaaGCCGGTATTCAAATATGTCGGTAGATATAAGGTTAATAGATTTGACGACACAAAAACACCATCACCAATAACACCCCTGTCTGCTCTAGACACACATCAGAAATTAACCCCTTGCTATGTTTATGCGGGTAGATCGAAACGAAAGTTAGAGTTCACTACCCCGAGTAATCACAAACTCGGGGTCACCACACCCCCACATACACCATCACACAAGTGGGATGAGATCCTACTGGTAGCCGATATGGAGTTGAGTAGGATTAATAAAGGAGTTTAG
Protein Sequence
MKIQLDSTAARLGVGKRRMYDIINILEAMKYAVHEKKNTYLWHGEAGLSSFLKILKKQGESLRLSEALRGRAPKPPPPKHKTLGILAKRFLMLFLVEPPNTLINLEMAVKVLIDTSNRNKTDLSPEQLDRQHKSKVRRLYDIANIFISIGLIEKVSGNLILKKPVFKYVGRYKVNRFDDTKTPSPITPLSALDTHQKLTPCYVYAGRSKRKLEFTTPSNHKLGVTTPPHTPSHKWDEILLVADMELSRINKGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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