Basic Information

Gene Symbol
Dis3
Assembly
GCA_013186455.1
Location
QDHC01002749.1:397778-404477[-]

Transcription Factor Domain

TF Family
CSD
Domain
CSD domain
PFAM
PF00313
TF Group
Beta-Scaffold Factors
Description
In molecular biology, the cold-shock domain (CSD) is a protein domain of about 70 amino acids which has been found in prokaryotic and eukaryotic DNA-binding proteins. When Escherichia coli is exposed to a temperature drop from 37 to 10 degrees Celsius, a 4–5 hour lag phase occurs, after which growth is resumed at a reduced rate.During the lag phase, the expression of around 13 proteins, which contain cold shock domains is increased 2–10 fold. These so-called 'cold shock' proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organisation of the prokaryotic nucleoid.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.72 6.8e+03 -2.7 0.0 18 38 180 200 176 209 0.76
2 4 0.044 4.2e+02 1.2 0.0 20 41 279 300 269 307 0.80
3 4 1 9.6e+03 -3.2 0.0 40 50 337 347 327 350 0.66
4 4 1e-09 9.9e-06 25.6 0.0 5 71 374 439 371 442 0.81

Sequence Information

Coding Sequence
ATGATGTGGACaacaaaaacctttttaacgAAAACTAAACGCGGTAACATTCTCAAAgttgTTAGGGAGCATTACCTACGCGACGACTTGCTGTGTGGGTCATCCGCTTGCAACAATTGCCCACATAAAGACAATGAGTATGTGTTGGAAGCTAAACCACAGTCTATCTGTGctttatttgattataatcattatttagTACTGGATACAAATGTTGTATTACACCAAATAGACATCCTAGAGGAGGATGCTCTCAAGAATGTTATCATACTCCAAACAGTACTAGAAGAAGTCAAGCATCAGAATACAGCTATATTTCAAAGGTTGTTGGAAATCATTGGTAATAAAAAGAGGAGATTCTATTCTTTCGTTAATGAACATCATAAAGATACATACGTTGAACGGAATCCTGGTGAGAAACAGAATGATAGAAATGACCGTGCTATACGTAGAGCAACATCATGGTACTCATCACATTtgagtattaataatttaaacggaCAATTTCCTCGGATTGTATTACTCACAGATGatgaaaataatagaaaacttGCTCAAGATGAAGGAATTGTTTGTTGTTcagTAAAAGATTATATAGAAAATGTTACCGGTTTCGTTGGACTCATTGACAAGTTATCTAAGAATGTGATACCAGAAAGCTGTTCTAAAGATGCATTGTATCCCGCACATTTGACTCCGAGTCAAGTTCACACTGGAATTAGGAACGAAAAGTTATATCAAGGAACGTTTTACGCTTCAAGGGATAATTATTTAGAAGGGTCTGCTGCTATCAGTTGTTTTGAAAAACcgattCTTTTACAAGGTCATATTGGAATTAATCGTGCTGTCGACGGAGATATTGTTGCTATAGAAGTGTTACCAAAAGATGAATGGAGAAAGCCAAGTGATATAGTTCTAGAAGATAAAGCGGATGATATAGGGGATCTTCTAGAAGAAGAATCTGAATTATTACCAACTGTGAAACCAAAGGATAAAAGTGATGATGAAATAACACCTACGGGGAAGGTAGTAGGAATTATAAGAAGGAAATGGAGGCAATATTGTGGAATTTTAAAACCTAGCAAATTCCCtgGAGCAACGCGTCATTTATTTACTCCAGCGGAGAGAAAGATACCTCATGTCCGTATAGAGACGCGTCAAAGTGATGTCCTAGCTTCGCAAAGGATACTTGTAGCTCTCGACTCTTGGCCTCGGAACAGTCGGTATCCTTTAGGACATTTTGTACGATCGTTAGGACCCAttggtgATAAGAATGCAGAAAATGAAGTAATTTTACTGGAACATGACATACCTCACGCTCGGTTCAGCGAGTCAGTGCTGGCCTGCTTACCGCCTGAAGACTGGACCATACCTGAAGAAgaaataaaaaagcgtGTGGACTTACGTTCGCTATGCATTTGCTCGGTCGACCCGCCGGGCTGCACGGACATTGACGATGCGTTGCACGCGCGCCCACTGCCCGTTACGCCTGGCGTCACCGGCGACAGTGGCGCCCTCGCCGTGTACGAAGTGGGCGTGCACATCGCCGACGTGACGCACTTCGTACGACCCAACACCGCACTAGACAAGGAAGCAGCTTCGCGCGCCACTACTGTTTATTTGGTGGATAAAAGAATAGATATGATCCCCGATCTGCTAAGTTCGAACCTGTGTTCGCTGCGCGGCGGCGAGGAGCGGCTCGCCTTCTCCTGCGTCTGGCATATAGACGAGAACGCTAATGTTCTCTCGACTAAATTCCATAAGAGTgttataaagTCCAGTTCAGCGATGACATACGAAGAGGCGCAGCTGGTGATAGACGATGTAGGGCGTAAAGACGATATCGCGCGTTCGCTGCGCACACTCAACACACTAGCTAAGAAACTGAAGCAGAAGAGGCTGGACAACGGCGCATTACTGCTCGCCTCACCAGAAATACGATTCCAGGTAGATTCAGAGACGCACGATCCCGTAGAGGTACAGGCTAAGAAGATATTGGACACCAACTCTATGGTGGAGGAGTTCATGTTGCTGGCGAACGTGAGCGTGGCGGCGCGCCTCGCGCGCGACTTCCCGCAGTGCGCGCTGCTGCGCCGCcacccgccgccgccgcccgcgcacTTCCACACCTTCCTTAAAGCTGCTAAGCAACAGGGTTTCGAATTAGACGTATCAACAAACAAATCGTTCTCGAAGTCTCTAGACCGCGCCGTGATCCCGTCTCGGCCGTTCTTCAATACATTGTTACGTATAATGGCGACGCGCTGTATGCAGCAGGCGGTGTACTTCGCGAGCGGCACGCGGCCGCACGAAGAATTCTACCATTACGTGATCCGAtcaaaaagaagaaaaagcaaaagaaataaaatatag
Protein Sequence
MMWTTKTFLTKTKRGNILKVVREHYLRDDLLCGSSACNNCPHKDNEYVLEAKPQSICALFDYNHYLVLDTNVVLHQIDILEEDALKNVIILQTVLEEVKHQNTAIFQRLLEIIGNKKRRFYSFVNEHHKDTYVERNPGEKQNDRNDRAIRRATSWYSSHLSINNLNGQFPRIVLLTDDENNRKLAQDEGIVCCSVKDYIENVTGFVGLIDKLSKNVIPESCSKDALYPAHLTPSQVHTGIRNEKLYQGTFYASRDNYLEGSAAISCFEKPILLQGHIGINRAVDGDIVAIEVLPKDEWRKPSDIVLEDKADDIGDLLEEESELLPTVKPKDKSDDEITPTGKVVGIIRRKWRQYCGILKPSKFPGATRHLFTPAERKIPHVRIETRQSDVLASQRILVALDSWPRNSRYPLGHFVRSLGPIGDKNAENEVILLEHDIPHARFSESVLACLPPEDWTIPEEEIKKRVDLRSLCICSVDPPGCTDIDDALHARPLPVTPGVTGDSGALAVYEVGVHIADVTHFVRPNTALDKEAASRATTVYLVDKRIDMIPDLLSSNLCSLRGGEERLAFSCVWHIDENANVLSTKFHKSVIKSSSAMTYEEAQLVIDDVGRKDDIARSLRTLNTLAKKLKQKRLDNGALLLASPEIRFQVDSETHDPVEVQAKKILDTNSMVEEFMLLANVSVAARLARDFPQCALLRRHPPPPPAHFHTFLKAAKQQGFELDVSTNKSFSKSLDRAVIPSRPFFNTLLRIMATRCMQQAVYFASGTRPHEEFYHYVIRSKRRKSKRNKI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00347289;
90% Identity
iTF_01143627;
80% Identity
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