CSD


Domain
CSD domain
Group
Beta-Scaffold Factors
PFAM
PF00313
Desciption
In molecular biology, the cold-shock domain (CSD) is a protein domain of about 70 amino acids which has been found in prokaryotic and eukaryotic DNA-binding proteins. When Escherichia coli is exposed to a temperature drop from 37 to 10 degrees Celsius, a 4–5 hour lag phase occurs, after which growth is resumed at a reduced rate.During the lag phase, the expression of around 13 proteins, which contain cold shock domains is increased 2–10 fold. These so-called 'cold shock' proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organisation of the prokaryotic nucleoid.
Rederence
  • Nucleotide sequence of a cDNA clone encoding a putative glycine-rich protein of 19.7 kDa in Nicotiana sylvestris. Obokata J, Ohme M, Hayashida N. Plant Mol. Biol. 17, 953-5, (1991).
  • Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation. Tafuri SR, Wolffe AP. Proc. Natl. Acad. Sci. U.S.A. 87, 9028-32, (1990).
  • RNP-1, an RNA-binding motif is conserved in the DNA-binding cold shock domain. Landsman D. Nucleic Acids Res. 20, 2861-4, (1992).
  • The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif. Doniger J, Landsman D, Gonda MA, Wistow G. New Biol. 4, 389-95, (1992).
  • Cold shock and DNA binding. Wistow G. Nature 344, 823-4, (1990).
  • Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein. Schindelin H, Marahiel MA, Heinemann U. Nature 364, 164-8, (1993).
  • The cold-shock response--a hot topic. Jones PG, Inouye M. Mol. Microbiol. 11, 811-8, (1994).
  • The solution structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1. Kloks CP, Spronk CA, Lasonder E, Hoffmann A, Vuister GW, Grzesiek S, Hilbers CW. J. Mol. Biol. 316, 317-26, (2002).
Statistic of Transcription Factors
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Transcription Factors Table

Statistic of Transcription Factors




Transcription Factor Table

Species

Gene ID Insect Gene Name Gene Symbol
iTF_00000082 Abrostola tripartita Atri016935.1 Dis3l2
iTF_00000083 Abrostola tripartita Atri015983.1 Dis3