Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.1e-27 1.1e-23 83.7 0.1 1 73 5 72 5 75 0.95

2 2 0.001 3.4 8.4 0.0 28 59 88 132 77 148 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.1e-27	1.1e-23	83.7	0.1	1	73	5	72	5	75	0.95
2	2	0.001	3.4	8.4	0.0	28	59	88	132	77	148	0.72

Coding Sequence: ATGAATATATCAATTGAACGAAAGAAAATGGAATGCCCAGCCTTACCGAAAGGTTGGCAAAGGGAAGAAGTATTACGAAAATCAGGCCTTTCAGCCGGAAAAGTTGATGTCTATTATTACAGCCCATCTGGAAAGAAATTCCGAAACAAACAACAACTGGCCCGTTATCTTGGCGAGAGCATTGACCTAACTACATTTGATTTTCACACCGGTCGTGTGAATCCTTTGCTGAGGAAAACTAAGAAGCCTCGTGGAACTCAATACGATTACAGCAGAGGAGTTAGAACAGACGCTTCTTTAGTTCCACCTATTAGACAAACAGcttctatttttaaacaacCAGTAACTGTTTTTAAAACACAAGAAGGTAAAGtgaaaacagatttaaaacatggCGGTCAAGAAAGACCAAAACAGTTATTCTGGGAAAAAAGATTAGagGGAATTCGAGCTTCAGACACAGATGGAACTAAACTATCTATAACTGAGCTTCCACGCGGATTGAAGCCAGTTGGTCCACATGTATCGGATGCCACAATGTTGCAATCACTAGCAACTGCTTTACACGTGTCGGCACAACCTGTAACAGgACAAACAGGATCGAAGACATCTTTAGGAAATAACCCCGGTGTGTTTTTAAACCCTGACCAGCCCTTAGCTTACGCTGTAAATATAAACGACGACGATATTCGACGGCAGGAAGAAAGAGTATTGGCAGTACGACGCAAGCTGCAGGAAGCACTTAGAGTTTAA
Protein Sequence: MNISIERKKMECPALPKGWQREEVLRKSGLSAGKVDVYYYSPSGKKFRNKQQLARYLGESIDLTTFDFHTGRVNPLLRKTKKPRGTQYDYSRGVRTDASLVPPIRQTASIFKQPVTVFKTQEGKVKTDLKHGGQERPKQLFWEKRLEGIRASDTDGTKLSITELPRGLKPVGPHVSDATMLQSLATALHVSAQPVTGQTGSKTSLGNNPGVFLNPDQPLAYAVNINDDDIRRQEERVLAVRRKLQEALRV

Sequence clustering based on sequence similarity using MMseqs2