Basic Information

Gene Symbol
Slc27a1
Assembly
GCA_947086415.1
Location
OX352293.1:28133820-28161880[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.25 6e+02 2.1 0.0 59 81 704 726 701 732 0.87
2 9 0.25 6e+02 2.1 0.0 59 81 741 763 738 769 0.87
3 9 0.23 5.5e+02 2.2 0.0 59 81 778 800 775 806 0.87
4 9 0.23 5.5e+02 2.2 0.0 59 81 815 837 812 843 0.87
5 9 3.7 8.7e+03 -1.7 0.0 60 81 853 874 850 878 0.85
6 9 0.23 5.5e+02 2.2 0.0 59 81 885 907 882 913 0.87
7 9 4.8 1.1e+04 -2.0 0.0 60 81 923 944 920 947 0.87
8 9 1.2 2.8e+03 -0.1 0.0 60 81 956 977 953 981 0.88
9 9 0.9 2.1e+03 0.3 0.0 60 82 993 1015 990 1020 0.86

Sequence Information

Coding Sequence
ATGTTGCTTGCCGGAGCCGCTGTAGTCGCAGCGTGTGCCTTTTTCCTCTATTATGGCTTTCTCTCCACTTTGACGGTATCTGTTGGTTTAGTGATAGTGTATATTGCCTTGTTCCACTGGAGATGGTGTTACGTCGCCCTGAGGACTATCCCGAGGGATATAGCAGCATTAATATGCTACGTAAAACTGCTATGGCTAACGAGACAGTTGACAAAGAAGAACTGGACTATTCCGGATGCATTCCACGAAACTGTGTCCCGCCATCCAAACAAACCATGCTTCCTGTACCAAGATGAAGTGTGGACTTTTAAGGAGGTGGAAGACTTCAGCTTACGCGTGACAGCCGTGCTGAAAGCGCAGGGCGTGAAGAAAGACGGCGTGGTGGGCATCCTGATGAGCAACTGCCCCCAAATGCCTGGCATCTGGATGGGCGCGGGCCGGTTGGGTGCGGTGTGCCCGCTCATCAACACGAATCAGCGCGGCAACGCTTTGATACATTCAGTCAACGTTGCTAATTGTGACGTCGTCATATACTCAGAGGAATATCAGACCGCAATTCAAGAGGTAGCCGGTCAATTGACTCCATCACTGAAATTATTGAAGTTTGTTCACCGGCCCCTCAATACCGCGAACACTGAAAACAAAGCCAGTGGCGATCAGATAACTGACCTGACATCTTTGCTGGAGACTACACCACCAGCGCCGTGGACCCTGGCTGATGCAGATGGCTTCCACGGGAAACTTCTATACATCTACACCTCTGGAACCACTGGATTGCCTAAAGCAGCCGTCATCTCAAGCTCTAGATTCGTGTTCATGGCCGCTGGTCTCCACTACCTGGGCGGTATAACTCCCGACGACACAGTGTACTGCCCGCTGCCGCTATACCACACGGCGGGGGGAATCATCAGCGCCGGCCAAGCGCTGCTCTTTGGGTGCACGGTGGCCGTCAAGGCCAAGTTCTCCGCGTCGCAGTACTTCCCCGACTGCATTAAGTATAAAGCTACGGTAAGACATGGTTTACTAAGTCTTAGTCCCACTAGTATAACTCCCGACGACACAGTGTACTGCCCGCTGCCGTTGTATCACACGGCGGGGGGAGTCATCAGCACCGGCCAAGCGCTGCTCTTTGGCTGCACGGTGGCCGTCAAGGCCAAGTTCTCCGCTTCGCAGTCCTTCCCCGACTTCCCACTACCCGCTATAACTCCCGACGACACAGTGTACTGCCCGCTGCCGCTGTACCACACGGCGGGGGGAGTCATCAGCACCGGCCAAGCGCTGCTCTTTAGGTGCACGGTGGCCGTCAAGGCCAAGTTCTCCGCTTCGCAGGACTTCCCCGACTGCATTAAGTATAAAGCTACGGTCGCCCACTACATCGGCGAGATGTGCCGCTACGTGCTGGCGACGCCGCCCGCGCCGACCGACACGCAGCACTCCGTCCGCACTATCTTCGGCAACGGCATGCGCCCTCAGATCTGGAACGAATTCGTGACGAGATTCAACATCCAACACGTTGCCGAGTTCTATGGAGCAACCGAAGGCAACGCTAATATAGTGAACATCGACAGTAAACCCGGCGCGATCGGGTTCGTGTCCAGGATTATTCCTCACGTGTACCCGATCGCGATTATAAAGGTGGACCAGGAGACTGGCGAGCCTATACGAGACTCCAGTGGACTTTGTCAGCTCGCACAGCCGGAGGAGCCGGGCGTGTTCATCGGCAAGATCGCGCCCAACAACCCCGCGCGCGCGTTCCTAGGCTACGTCGACAAGTCCGCGTCCGACAAGAAGATCGTCAGAGACGTCTTCGCTAAGGGAGACTCGGCGTTCATCTCCGGCGACATCTTAGTGGCAGACGAGCTGGGCTACCTGTACTTCCGCGACCGCACGGGCGACACGTTCCGCTGGCGCGGCGAGAACGTCAGCACCACCGAGGTGGAGAGCGCCGTGTCGCGCGTCGCTGACCAGAGAGACGCTGTTGTCTATGGAGTCGAGGTTCCAAACGCGGAAGGGCGTGCTGGCATGTGCGGCATCGTCGACGTCAACGGAACTCTCGACCTGGACAAGTTAGCGCGGGACCTGGCCAAGGACCTGCCTGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAAGTCACAGACCTGGACCGTAGACAAGTTAGTGCGGGACCTGGCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAAGTCACAGACCTGGACCGTAGACAAGTTAGTGCGGGACCTGGCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAAGTCACAGACCTGGACCCTAGACAAGTTAGTGCGGGACCTGGCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAAGTCACAGACCTGGACCCTAGACAAGTTAGTGCGGGACCTGGCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAAGTAGGTCACAGACCTGGACCCTAGACAAGTTAGTGCGGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAAGTCACAGACCTGGACCCTAGACAAGTTAGTGCGGGACCTGGCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAAGTAGGTCACAGACCTGGACCCTAGACAAGTTAGTGCTGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGCATGGACATGACAGGTAGGTCACAGACCTGGACCCTAGACAAGTTAGCCTGGGACCTGGCCAAGGACCTGCCCGCGTACGTGCCCCCGGTCTTCATGCGGGTCATGCCGAGTATGGACATGACAGGTAGGTCACAGACCTGGACCCTAGACAAGTTAGCGCGAGACCTGTCCAAGGACCTGCCCGCGTACGCGCGCCCGGTCTTCATGCGGGTCATGCCGAGTATGGACGTGACAGGTACATTTAAAATGAAGAAAACCGACTTGCAAAAGGAAGGTTTCGATCCTGCCATTGTGAAGAAAGACAAGCTATACTACCTCGACGCGAAATTGGGCCGGTACCTACCGCTGGGCAAGGAAGAGTATGAAAAAATTGTTCAAGGACAGATACGAATATGA
Protein Sequence
MLLAGAAVVAACAFFLYYGFLSTLTVSVGLVIVYIALFHWRWCYVALRTIPRDIAALICYVKLLWLTRQLTKKNWTIPDAFHETVSRHPNKPCFLYQDEVWTFKEVEDFSLRVTAVLKAQGVKKDGVVGILMSNCPQMPGIWMGAGRLGAVCPLINTNQRGNALIHSVNVANCDVVIYSEEYQTAIQEVAGQLTPSLKLLKFVHRPLNTANTENKASGDQITDLTSLLETTPPAPWTLADADGFHGKLLYIYTSGTTGLPKAAVISSSRFVFMAAGLHYLGGITPDDTVYCPLPLYHTAGGIISAGQALLFGCTVAVKAKFSASQYFPDCIKYKATVRHGLLSLSPTSITPDDTVYCPLPLYHTAGGVISTGQALLFGCTVAVKAKFSASQSFPDFPLPAITPDDTVYCPLPLYHTAGGVISTGQALLFRCTVAVKAKFSASQDFPDCIKYKATVAHYIGEMCRYVLATPPAPTDTQHSVRTIFGNGMRPQIWNEFVTRFNIQHVAEFYGATEGNANIVNIDSKPGAIGFVSRIIPHVYPIAIIKVDQETGEPIRDSSGLCQLAQPEEPGVFIGKIAPNNPARAFLGYVDKSASDKKIVRDVFAKGDSAFISGDILVADELGYLYFRDRTGDTFRWRGENVSTTEVESAVSRVADQRDAVVYGVEVPNAEGRAGMCGIVDVNGTLDLDKLARDLAKDLPAYARPVFMRVMPSMDMTGKSQTWTVDKLVRDLAKDLPAYARPVFMRVMPSMDMTGKSQTWTVDKLVRDLAKDLPAYARPVFMRVMPSMDMTGKSQTWTLDKLVRDLAKDLPAYARPVFMRVMPSMDMTGKSQTWTLDKLVRDLAKDLPAYARPVFMRVMPSMDMTSRSQTWTLDKLVRDLPAYARPVFMRVMPSMDMTGKSQTWTLDKLVRDLAKDLPAYARPVFMRVMPSMDMTSRSQTWTLDKLVLDLPAYARPVFMRVMPSMDMTGRSQTWTLDKLAWDLAKDLPAYVPPVFMRVMPSMDMTGRSQTWTLDKLARDLSKDLPAYARPVFMRVMPSMDVTGTFKMKKTDLQKEGFDPAIVKKDKLYYLDAKLGRYLPLGKEEYEKIVQGQIRI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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