Basic Information

Gene Symbol
Hnf4
Assembly
GCA_963921995.1
Location
OY998163.1:9525999-9541501[-]

Transcription Factor Domain

TF Family
RXR-like
Domain
zf-C4|RXR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 2.8e-67 1e-63 216.1 0.3 1 196 23 211 23 215 0.98
2 8 0.25 9.1e+02 0.8 0.0 121 144 219 242 213 243 0.89
3 8 2.3e-08 8.6e-05 23.7 0.1 165 196 243 274 242 279 0.94
4 8 4e-20 1.5e-16 62.1 0.2 121 197 282 356 276 361 0.94
5 8 1.9e-22 7.1e-19 69.7 0.2 121 196 363 438 356 445 0.94
6 8 3.8e-23 1.4e-19 72.0 0.1 121 196 446 521 440 527 0.95
7 8 4.3e-23 1.6e-19 71.8 0.1 122 196 530 604 525 609 0.95
8 8 5.8e-15 2.1e-11 45.3 0.1 121 178 612 669 607 673 0.95

Sequence Information

Coding Sequence
ATGGGCACCACTCCAGTCAACAACGATTTGGACTTATCCAACAGGCAGCTGGCGAACATTGACGACATCTGTGATTCGATGAAGCAGCAACTTTTAATTCTAGTCGAATGGGCCAAGTATATTCCCGCTTTTACCGAGTTACAGTTAGACGACCagGTAGCGTTACTGAGGGCGCACGCAGGAGAGCACCTTTTACTAGGCTTGGCACGGCGGTCGATGCATCTCAAAGAAGTCTTACTCCTAGGAAATAATTGTATCATAACGAAACAGTGTCCTGatCTGAGCATAGCCCGAGTAGGAACCAGAATTATGGACGAATTAGTCCGACCAATGACTGACGTTCAGATCGACGATACAGAGTTCGCCTGTTTAAAAGCTATAGTTTTTTTCGACCCAAATGCCAAAGGTCTAAACGAGCCGGCCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTACATCAGCGACAGACAGTACGACAGCCGGGGTCGCTTCGGCGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCGATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGGGTGACGCACATTGACAGCTTGTTGCAAGAAATGTTGCTTGgagaagttaaaaaacctccgaatcagttacttcaaccggcCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTACATCAGACAGTGGATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGGGTGACGCACATTGACAGCTTGTTGCAAGAAATGTTGCTTGgagaagttaaaaaacctccgaatcagttacttcaaccggcCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTACATCAGACAGTGCGACAGCCGGGGTCGCTTCGGCGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCTATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGGGTGACGCACATTGACAGCTTGTTGCAAGAAATGTTGCTTGGAGaagttaaaaaaccttcgaatcagttacttcaaccggtCCGCATCAAGCAACTGCGCTTCCAAATCCAAATAAACCTAGAAGACTACATCAGCGACAGACAGTACGACAGCCGGGGTCGCTTCGGCGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCTATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGAGTGACGCACATTGACAGCTTGTTGCAAGAAATGCTGCTTGgagaagttaaaaaacctccgaatcagttacttcaaccggcCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTACATCAGCGACAGACAGTACGACAGCCGGGGTCGCTTCGGCGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCGATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGAGTGACGCACATTGACAGCTTGTTGCAAGAAATGTTGCTTGgagaagttaaaaaacctccgaatcagttacttcaaccggcCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTACATCAGCGACAGACAGTACGACAGCCGGGGTCGCTTCGGCGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCGATAACGTGGCAGATGATCGAGCAGATACAGTTCGCGAAGCTGTTCGGAGTGACGCACATTGACAGCTTGTTGCAAGAAATGTTGCTTGgagaagttaaaaaacctccgaatcagttacttcaaccggcCCGCATCAAGCAACTGCGCTACCAAATCCAAATAAACCTAGAAGACTATATCAGCGACAGACAGTACGACAGCCGGGGTCGCTTCGACGAGTTGCTCCTGACGTTGCCGCCTCTCCAATCGATAACGTGGCAGATGATCGAGCAGATACAGTTCGATACAAGACGGGTTAGATTAGGTGGAATGGAAAACAGCATAGTCGTTCCCGGAACGACAATGGGGGTGCAGCAACAGCAGCCGCAACAGCTCAACAACAACAGCTACCAGGGTGCCGTCAGCGACTCGACCGACAGTCCGGTGTTGTCGCCCATGACTACACCCAACAGCCCCGATCAGCTGATTAACGGCGGCGGCGTTGCCAGCCCGCAGTCCAATTCTAGCGTTTTAATTATGCGAGATCTTGGTGgaATAGACGAAACATTCGCAATGCCTTTCAAACATGAACCTATCAAGGAAGAACAACACACTTACTAA
Protein Sequence
MGTTPVNNDLDLSNRQLANIDDICDSMKQQLLILVEWAKYIPAFTELQLDDQVALLRAHAGEHLLLGLARRSMHLKEVLLLGNNCIITKQCPDLSIARVGTRIMDELVRPMTDVQIDDTEFACLKAIVFFDPNAKGLNEPARIKQLRYQIQINLEDYISDRQYDSRGRFGELLLTLPPLQSITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPPNQLLQPARIKQLRYQIQINLEDYIRQWITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPPNQLLQPARIKQLRYQIQINLEDYIRQCDSRGRFGELLLTLPPLQSITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPSNQLLQPVRIKQLRFQIQINLEDYISDRQYDSRGRFGELLLTLPPLQSITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPPNQLLQPARIKQLRYQIQINLEDYISDRQYDSRGRFGELLLTLPPLQSITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPPNQLLQPARIKQLRYQIQINLEDYISDRQYDSRGRFGELLLTLPPLQSITWQMIEQIQFAKLFGVTHIDSLLQEMLLGEVKKPPNQLLQPARIKQLRYQIQINLEDYISDRQYDSRGRFDELLLTLPPLQSITWQMIEQIQFDTRRVRLGGMENSIVVPGTTMGVQQQQPQQLNNNSYQGAVSDSTDSPVLSPMTTPNSPDQLINGGGVASPQSNSSVLIMRDLGGIDETFAMPFKHEPIKEEQHTY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01128616; iTF_01128477;
90% Identity
iTF_01128616; iTF_01128477;
80% Identity
iTF_01128616; iTF_01128477;