Basic Information

Insect: Oxycera nigricornis
Gene Symbol: MBD-R2
Assembly: GCA_963942545.1
Location: OZ012659.1:3016720-3020393[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.6e-16 6.2e-12 46.5 0.1 3 76 400 471 398 472 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.6e-16	6.2e-12	46.5	0.1	3	76	400	471	398	472	0.93

Sequence Information

Coding Sequence: ATGACGCGGCGTTGTATAATCCAAGGTTGCACGTCAAAATCGGGCAATCCCCAGCATCGCGGAGTCACCTTTCATTCGTTCCCGTTCGACTCGAAGACGCGCGAAGTGTGGCTGCTGAACTGTCGCATCGATCCCGAGAAAAACATCACGAAGAGCGTGTTGGTGTGTTCGCGCCACTTTCGCCGCGCTGACTTCCAGCCGGTCAAGTCGAACAAGTATCTTCTGAAGCAAGGCTCGGTGCCCACGATCTTCCCGTGGGGGAAGCTGGCGCCGTTCTCAGCGGCTGCAGCGTCCGAAGAAACTGCGCCTCCGCTCGTGCTGCAGAGCGAAATGGAAGTCTCCACGGACGATGGAAGCAAGTCCAACACAACCGCAAGCGAGGTGGAAAGCGAGAAGCCCGCATTGAAGCGCACGTCGCAAGATTCCGTGCTTGCCCCGGAGCCCAAGATGCCGAAGCTTAGCAGCCCAGGGTCGCCACCGGCCGTGGCAACCGACATACAGAGTTTGGTGCCGCTTGGGACCATCCCCGCAGCGGAAGGCAGTCGCAAGTCGGACACGGTGTCGGGGTTTGTGCCCGGCGTGCGCTTGGAGGCGCAGGACTTCGATGGCATCTGGCACACAGCGCGCGTGGTGGAAGTGGACAACGACGACCGGGAAGTGCTGATTCGGTTCGAGAAGAGCGGCAAGTCCAAAGGTCCCAGCGGGGCGGATGAGTGGATTCCAATGAACAGCAGCCGGCTGCGACAGAAGGCCGCGGCGGCTAGCAAGTCGCCCAATGTGTTTGTTCTCGGCGAGAAGTGCCTGGCCCGGTGGAGTGGCGCGCGCCGCTTTCCGGCCACTGTGCAGAAAGTGCTTGCCAACGACATGTACGAGATCTTGTTCGATGACGGCTACATGAAGGTACTGAAGAGTGCGCACATAAGCAAGCTGAAGTTGCCTGTCAGCAGAGCTCAGCCAGCGGCCGAATCCACCAGGGCCGCTCCAAAGCCAGCGGCGGCGAGTGCAACGCCCGAAAAGGCCAAACCGAAAAGTCAACCATCGAAGAACAATTGGCCACTGATCTCGATGAGCTCGCTGAACTTGGCCGAGCTGGACCTGCCCGAGATCCCCAAGGACGGAGAGTGGTGCTGCCACTGGGTGAATGATCAGCCCATCGGACGGGAAGGATTCCTCACCGTGGGCGAGCATAAGAAGCCCACCGTGATTGTGGATGACTGGCGCCTGCCGGTCGGCTGGACGAAACACATGTACCAGCGGTCGAATGTGCTGGGCAAGTGGGACGTGATACTCGTCAACTCGAACAGCAAACGGTTCCGGTCGAAAGCAGACTTGAAGCAGTACATCGAAGATCTCGGGCAGCACTACAACCCAGACGTCTATGATTTCAGTATTCATCGCAGGCGGGCCAAGGACATCGGCGCATACGCCTACACCAAAGATTACAAGCCACCACAGCCAGTCAAACCGCCACCTCCAGCGCTCGAACCTATTCCGCCGTTGCAACCCCAAACTCGGGTAGAGAGCCCTACTCAGATCGTGGTTGAGTCCGTTGTACAAGCCACCACGCCACAGCCAGCTTTGTTCGATTCGCTGCCAATTCGGTTGACCGATGACGATTCCACTCTCCCGGAGGATGGCTATGTATACGTGGGTGCATTGAAAGTACAAATCGTCGACAACCTGTTCCGATGCCCCAAAGAGGCTTGCAACAAAAACTTCCGCAAGGAGAACCATTTGCAAATTCACGTCAAACACTATCACGACGACATTGCAAAACTTCTTGGCGCCTGCCCCAATATGCAGGAGCTTGCCTGCAAGCGAACGATTGGCCACCCGCCCGATGAACCGCTCCCCAAAAACTATCTGCCGAATGCGCAATATTTTGCGAAGCTTCACCAACAAGATTTGCAGAACAGATTGCACCGGAAGTCCACATCGACGCCCCTCACTCCAACCGCCTCGACTCCTACCCGAAATGACGCTCTGGACAATTACTCGTTGAGCTTGGACGATGCAAGCAAACTCGATGTCAGTGCTCTAGAAGCGACGCTCGGAACCAGCCTCATTGCGGGAAGTCCTTTGGTCGAGAGTTCCAGCTTCATCCATGCAACAGGAGATGAAAGCCCCATCAAAGACGCAATGGAGCCGAAAACGCCATCACAATCGCAGCCCGTTGCCAAGCCAATCGCCCGAAAGTCTGGCGAACGCAAAAGCTCTCGTCAGAGGCTTCAAAAGAGATACCCGACTGCCAGCACGTCCACCGTCTTCGATAACTCGTTCCAGGTGTCCACTGTTCAGGTGTCCGACCTGGAAGATACGAGACATTCCTTCAATGGCACCCCAGAGAATAGGATCGCTAAAAAGGCGAAACTTTCTCATCCCACATTCGTCCAAGATGCGAACCTGGACGGCAACACAACGGGCAGCGCCCCGGAGCCAATCCCAAATCAAAGCCCAAAATACATCCAGGAAAACGGGGAAGTGATCAAAATAGTGCGAATGCGGTCCGAGGAAATCATCAATTGCATTTGCTCGTTCGGCGAAGAGGACGGTCTGATGATACAGTGCGAGCTGTGTCTGTGCTGGCAGCACGGAGTGTGCAACGGCATCGAGAAGGAGAGCCAAGTTCCGGAGAAGTATGTGTGTTACATCTGCAAGAACCCTCTGCTTGCGCGAAACAGCATGAAGTACGTCCACGACCAGGACTGGCTGTACGATGGCAAGCTGCCCACTGGCAATTACCATGCGCCCAACCCAAAACTGCAAGATCGCTTCAACATTTTGCGGACCAGTCACACATTGACCGGCAACCTGATCGAATTGAAGCGTTTCCTTCGTAGTCTTCGAGTGAAAATCAACATCGCCGAAAACAAGCATCACCCGAAAATGTACTTGTGGGCCAAAAAGTGGGAAATGTCGCCAACGTCAGCTATTGAACCGAAGATGGAGAAAACAGACAGCGATGCGATGGAATCGCGCGGCGAAAAAGCGCCTGAACATGCAGAGTTGAAAGATGCACTCGCCAAGTCGGAGGCCGTCATCAAGGAGGAGGAGGACAACCTGGCCGGCTCGGAAACGATTGAAAAGTCGGAGAATGTGACTGTTAAAGAGGAACTGGAGAGCGAGCCGAAACGCGAGGTGGTGATAACTCAACCAAACATTCCGCAGCCAGAAGCTGCAATTGATCCAGTCGAGTGCCAGCATAGATTACTGGAGCACATCCAGAAACAGCAGACGCTAGTGGTGGAGCGCCTACAAGACATCGAATCCGATATTGTCGAGTTAGAATCATTGGATCCCATTACTGATCTCGACAGCGAGGATTTTGGCCGCACCAAGCAAACGCTGGCGATATTGATAAAGGATCTGGAGACGATGCAAAACCTGGCGAAAATCAATTTGGCGTCTGCGCAAAGCTATGTACCACATGCCTAa
Protein Sequence: MTRRCIIQGCTSKSGNPQHRGVTFHSFPFDSKTREVWLLNCRIDPEKNITKSVLVCSRHFRRADFQPVKSNKYLLKQGSVPTIFPWGKLAPFSAAAASEETAPPLVLQSEMEVSTDDGSKSNTTASEVESEKPALKRTSQDSVLAPEPKMPKLSSPGSPPAVATDIQSLVPLGTIPAAEGSRKSDTVSGFVPGVRLEAQDFDGIWHTARVVEVDNDDREVLIRFEKSGKSKGPSGADEWIPMNSSRLRQKAAAASKSPNVFVLGEKCLARWSGARRFPATVQKVLANDMYEILFDDGYMKVLKSAHISKLKLPVSRAQPAAESTRAAPKPAAASATPEKAKPKSQPSKNNWPLISMSSLNLAELDLPEIPKDGEWCCHWVNDQPIGREGFLTVGEHKKPTVIVDDWRLPVGWTKHMYQRSNVLGKWDVILVNSNSKRFRSKADLKQYIEDLGQHYNPDVYDFSIHRRRAKDIGAYAYTKDYKPPQPVKPPPPALEPIPPLQPQTRVESPTQIVVESVVQATTPQPALFDSLPIRLTDDDSTLPEDGYVYVGALKVQIVDNLFRCPKEACNKNFRKENHLQIHVKHYHDDIAKLLGACPNMQELACKRTIGHPPDEPLPKNYLPNAQYFAKLHQQDLQNRLHRKSTSTPLTPTASTPTRNDALDNYSLSLDDASKLDVSALEATLGTSLIAGSPLVESSSFIHATGDESPIKDAMEPKTPSQSQPVAKPIARKSGERKSSRQRLQKRYPTASTSTVFDNSFQVSTVQVSDLEDTRHSFNGTPENRIAKKAKLSHPTFVQDANLDGNTTGSAPEPIPNQSPKYIQENGEVIKIVRMRSEEIINCICSFGEEDGLMIQCELCLCWQHGVCNGIEKESQVPEKYVCYICKNPLLARNSMKYVHDQDWLYDGKLPTGNYHAPNPKLQDRFNILRTSHTLTGNLIELKRFLRSLRVKINIAENKHHPKMYLWAKKWEMSPTSAIEPKMEKTDSDAMESRGEKAPEHAELKDALAKSEAVIKEEEDNLAGSETIEKSENVTVKEELESEPKREVVITQPNIPQPEAAIDPVECQHRLLEHIQKQQTLVVERLQDIESDIVELESLDPITDLDSEDFGRTKQTLAILIKDLETMQNLAKINLASAQSYVPHA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01127460;
90% Identity: iTF_01127460;
80% Identity: iTF_01127460;