Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.2e-53 1.1e-48 168.0 12.2 125 300 46 225 32 225 0.91

2 2 0.0058 1.9e+02 3.0 4.8 120 171 223 274 222 287 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.2e-53	1.1e-48	168.0	12.2	125	300	46	225	32	225	0.91
2	2	0.0058	1.9e+02	3.0	4.8	120	171	223	274	222	287	0.86

Coding Sequence: ATGATCAGTGAAAAACCTGCTAAGCACCTTAATTTAATAGCACTGTCTAATGACACTTTTAAGAAACTAATTGATTGTATGTCAGCGAATATCAAAGAAAAGTTGGCAAGAAGAGAAGAGAAGAAGACGAAAGTACAGAGACTAGAGGAGTCCGAAGAAAACTATTCCCAATTAAAGCGGGAGCATAGAGAGAAATGTCGAGACTTCGAGCAACTGAAACGATTGACCGTCAAGTTAAAAGAAGAATTGGCTCTGGTGAACTCCGAGTTGGAGGAACGTGATAGGTTGATAGCTGAAAAGGGCCTAGTGATAGTAGGTGAAGAGGAGCCTGTTTGTGAGGAGAATGGGGAGACTCTTACAAATGGCCCGACTAGGATTAGGAGGGCACTCGTTAGCTCCGAAAACGCGCAATTCTTAGAGAATGCAGGCGAGGGTAGTTTAGATGTGCGATTGGCGAGATTTGTGAAAGAGCGAGGCGAGTTGCAAGATCTAATTAGTCATTTAAAATTAGAGCTGGAGGATGAGAAGAATAAACGTAGGAAACACAGTGGTTCAACTTTAAACGGCCCCAATTTCGACTCCGAGTATGATGCGGCAGATATACAAAGGGAAGCTAGCAAACAGTTGGCGGAGTTCAAGTTTAGGGCGCAGAAGGCTGAGCAGGATGTGGCCACATTGCAGGCAACTGTGGCACGGCTGGAGAGCCAAGTGATCAGGTATAAGTCGGCCTCGGAGATCTCGGAGAAGTCCGAAGAGGCCCTCAAGGCGGAGAAAAGGAAGCTTCAGCGAGAGGCACGAGAAGCACAGAATAGGGCAGAGGAGTTGGAAATGTCCAACACACATTTAATTAAACGTTTAGATAAACTGAAGAATGCAAAATCAGCACTACTTAAGGAACTTTGA
Protein Sequence: MISEKPAKHLNLIALSNDTFKKLIDCMSANIKEKLARREEKKTKVQRLEESEENYSQLKREHREKCRDFEQLKRLTVKLKEELALVNSELEERDRLIAEKGLVIVGEEEPVCEENGETLTNGPTRIRRALVSSENAQFLENAGEGSLDVRLARFVKERGELQDLISHLKLELEDEKNKRRKHSGSTLNGPNFDSEYDAADIQREASKQLAEFKFRAQKAEQDVATLQATVARLESQVIRYKSASEISEKSEEALKAEKRKLQREAREAQNRAEELEMSNTHLIKRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2