Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.005 1.1e+02 5.2 0.0 21 46 84 109 78 115 0.81

2 7 0.0085 2e+02 4.5 0.2 21 44 112 135 108 139 0.86

3 7 0.00012 2.7 10.4 0.0 21 45 140 164 136 173 0.87

4 7 0.072 1.6e+03 1.5 0.3 21 40 168 187 164 194 0.71

5 7 0.00053 12 8.4 0.0 12 46 188 221 180 227 0.77

6 7 0.0012 26 7.3 0.0 21 49 224 251 220 257 0.87

7 7 0.39 8.9e+03 -0.8 0.0 21 43 280 302 267 308 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.005	1.1e+02	5.2	0.0	21	46	84	109	78	115	0.81
2	7	0.0085	2e+02	4.5	0.2	21	44	112	135	108	139	0.86
3	7	0.00012	2.7	10.4	0.0	21	45	140	164	136	173	0.87
4	7	0.072	1.6e+03	1.5	0.3	21	40	168	187	164	194	0.71
5	7	0.00053	12	8.4	0.0	12	46	188	221	180	227	0.77
6	7	0.0012	26	7.3	0.0	21	49	224	251	220	257	0.87
7	7	0.39	8.9e+03	-0.8	0.0	21	43	280	302	267	308	0.73

Coding Sequence: ATGGAAGAGGGCCCTTATGTCATATCATCAcagcattttacacaagaaaacTTGGAACGCcgcaataaaataatgataaccCACGATTCTAACGGGGAAAAGTACGTATGCTCGGCCGTGTTCCTGTGCAAGAATTCCTGTATGGGTCAGATGCGTCGTCACGAAGGTACGGCGAAGCATATCTGTGAGATATGTGGCAAGAGGATGATTACAGCCGCTTCGCTGGTCATTCATAAGCGGACACATAGTGGAGAAAGGCCGTTCGCCTGCGATATTTGTGGAAAAGCTTTCACCAAGAAGAGACATATTACGAGTCATTTGCGGacgcatactggagaaaaaccgttctgCTGCGAAATTTGTGGAAAGGTTTTCGCCCGGAAGACACATATTACGAGACATTtccggacacatactggagaaaaaccgttcacCTGCGATATTTGTGGAAGCGCTTTCATCCAGAAGCCAAATTTGACGGCACATTTGCGGTCACATACTGGAGAGCGACCGTTCGCCTGCGAcatttgtggaaaggctttTACCCAGAGGCCAAGTTATACGGCACATTTGCGGTCACATACTGCAGAAAAACCGTTCTCCTGCGACATTTGTGGAGAGGTTTTCGCCCAGAAGGCTTACATTACCACACATTTGCGGACCCATACTGGcgagaaaccgttcgtttgcgatattTGCGACAATGCTTTCTCCACCAAAACAAGTCTTAAGCGACATGTGTTGAggcatactggagaaaaaccattcgCTTGCGATACTTGTGGGAATGCTTTTTTCACCAAATCAGAGGTTAAGGAACATACACGGATACATAGCGGAGAAAAGCCGTTTGTGTGCGGCACTTGCGGGAAGGCTTTCACCACGAAATCAAACCTGGTTGGTCATGCACGGATACATACCAAAGAGAAGCATCGTAAAATGCGTTTTGCGATTAGAGATTCAGCCATACTCAAACTTTAA
Protein Sequence: MEEGPYVISSQHFTQENLERRNKIMITHDSNGEKYVCSAVFLCKNSCMGQMRRHEGTAKHICEICGKRMITAASLVIHKRTHSGERPFACDICGKAFTKKRHITSHLRTHTGEKPFCCEICGKVFARKTHITRHFRTHTGEKPFTCDICGSAFIQKPNLTAHLRSHTGERPFACDICGKAFTQRPSYTAHLRSHTAEKPFSCDICGEVFAQKAYITTHLRTHTGEKPFVCDICDNAFSTKTSLKRHVLRHTGEKPFACDTCGNAFFTKSEVKEHTRIHSGEKPFVCGTCGKAFTTKSNLVGHARIHTKEKHRKMRFAIRDSAILKL

Sequence clustering based on sequence similarity using MMseqs2