Basic Information

Gene Symbol
RREB1
Assembly
GCA_031763485.1
Location
JARFOC010000066.1:368542-375110[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.0001 0.025 17.2 1.5 1 23 92 114 92 114 0.98
2 15 0.00031 0.078 15.7 0.2 1 23 127 149 127 149 0.97
3 15 7.1e-06 0.0018 20.9 4.3 1 23 155 177 155 177 0.99
4 15 0.3 76 6.3 0.1 1 23 238 262 238 262 0.86
5 15 0.017 4.3 10.2 0.6 2 23 268 290 268 290 0.90
6 15 0.061 15 8.5 0.6 1 21 337 357 337 358 0.96
7 15 0.094 24 7.9 0.1 1 23 491 513 491 513 0.96
8 15 1.6e-05 0.0041 19.7 0.4 1 23 522 544 522 544 0.99
9 15 0.001 0.26 14.1 3.1 1 23 550 573 550 573 0.97
10 15 0.00088 0.22 14.3 2.8 1 23 928 951 928 951 0.96
11 15 0.00023 0.058 16.1 0.4 2 23 1169 1190 1168 1190 0.97
12 15 0.16 39 7.2 6.3 1 23 1196 1219 1196 1219 0.97
13 15 0.045 11 8.9 4.9 1 21 1247 1268 1247 1271 0.95
14 15 0.021 5.2 10.0 0.4 3 23 1394 1414 1392 1414 0.93
15 15 0.0093 2.3 11.1 5.9 1 23 1420 1442 1420 1442 0.98

Sequence Information

Coding Sequence
ATGCAAGGCATCGTTTTTATGCCGCACAATTTGGAAACAGGCTCCCCGCCACTACATAAAGATACTGATTCTAATGAAAATATGGACACCATAACGACTGAACCAAACATAATCCATACCAAAGAACCGCCGGTCAACCAAAGCAGCAGAAGCGATTCTGGTTTCCTATCGATCACCAACAACACAACGTATCCAGATTCGGAGGAGAGGACACACCAAGATAACGGCGACACGGACAATAGAAGCGACTGCAGCTCGCCGGACGGCCGAAAGTACTATTGCCCAATCTGCGAAAGAATGCTCACCTCCCAACACGAATTTACCCTACACATCAGATCTCACAACAACGACTCGGATTCGCAATGTCAGGACAAGGGTTTCGTCTGTAGAATTTGCTCCAAAGTGCTCAGCTCGAGTTCGAGCCTTGATCGACATGTTTTGGTCCATAGTGGGGAAAGACCATTCACTTGTAAATACTGCGGCGATACCTTCACGACAAACGGCAACATGCACAGACATATGAGAACCCATTCATTCAAGAACGACTATGAATCAGACGGTAGCACCGATAGTAGCAGTAGTAGTAACTCAAAAACCGTAGAATACAACAACAACAAAGTAGAAAGGTATGAGAAACGAAAATTAGCGTTGtgcgaaaattataaaaatgcacGGATTAAATTAGAAGATGACGATGGTAatggagataaatacaaatgtCCGGTATGCGAACGCGACGATTTCGCGAGCAAAACAAATTTGGAAATACATTTGGAGGACAATCATCCCGATTTTCCCGCAAAATGTCAGGAGTGCAACAGCACGTTTAAGAACAACAAACTTTTAGCGATGCACAAAGCTGCCGCTCACGAAGAGTGTGGAAAACACAGAAATTCTGTTGTGGGATTTAAAGACCTCACGTTCGTCGATTTTTCCAGCGAGAAGTTCCCACATATAGCTCGACACGAATGCGAAAAGAATCTACACAAGGCCTCCTCCGGATTAAGATTCCAGTGCCAGAAATGTTCTAGGGCTTTTCCGTGTGCAAATTCCTTGGAGATTCACCAGAGAGGATGTTCTGTTGGCGTAGATTTAAGCGTGACCAACGAAAATTCTATGAACTTGACAAAATCCCCGACACTGAATGAGAACGACGTGAAACGCGCAGATTTCTTTTCTAGACTAGACCTACAGGATAATTCTCCagaaaagaacgaatttgatgGTAGTAAGCTCCAGCAAAAACTATTAGAAACTGTGAATTTAGATAACAGCAATAACAAAGACCTAGCTGACATTCAATCAATAATATCGATGACGAGGAACGGTAGTTTTTTGCAACACTTGCAAACGAAAGGCGATATGCCCAACCATCAGGCAGCGCCAGATTTACAGCTGGAAAaaaccgaagaagaagaagctcAAGATGTATTCGCTAAAGAATTTCGAAAGATGAAATTGAGAGGCGAATTTCCGTGTCGCCTTTGCAGCGCAGTCTTTCCAAATTTGAGGGCCCTTAAAGGTCACAACCGCGCTCACTTGAATGGAAATACTAACGGAACGTATAGATGCAATATGTGCCCCCATGCTTCCGTAGATAAGGCAGCTCTAATTCGCCATATGCGCACTCATAATGGAGATAGACCTTACGAATGCAGTTTGTGCAATTACGCGTTTACAACTAAAGCGAATTGCGAACGCCATTTGAGGAATAGACACGCGAAGACTACCAGGGAAGAAGTTAAAAAATCCATAATTTATCACCCCTCGGAAGATCCTACTAACGACGACATAAACAAGTTGGTAATAAGAGAAGATATCAGGAAAATAAATTCTAGCTTCAACTCGACTGAATCCACTGAGATAAGCCCTGAAAAATTGAGAAGTTCTACACCTAAAATGCACCCCAGCGATTTATTTGGAAGCCACAACGAACCCAATCCATTAATTCCTATCCCAACCCAGGTAACATCGTGGAGAACTTCCTTTATTGATACCTCACCTGTTAAATCAATccaagaaactaaaattaaaaccGAAATGCCGTACTTACAACAACTCACATTTATGCCAAAATCCGACAATGTTTCGACGCCCCAAAAATCCGTTCCAAAAATACACGTTAAAAATTTAGACAGATTAAAGCAGACTGAATACGAGTGCAACGAAGATGAGAAATACGAACACTACCCCGATGACGAACCGATGGATTTGAGTAAGAAGAAAACTCCTGAAATTGAAGCAGCAAGTGACCACAACAATGATGAAACTCCGGAAGACTTGTCAAGCAAAAAACCTAACTTGACTCCCTTTAATATGACCGAAATCCTAACGCAACAATTGCTGATGAAAAACACGCCCGTAGATCCAACCAGTTTCTACGCAGCCCAATTAGCGTTTTGCAATTCCTTCTCTGGATGGTCACCGTTTTCACCTATAACTCCCTTGCTTTTTCAAAATCCCATCTTACCTCAAGAGCAGGAAATGAAACGCTTGCAGCGCCAACTTTGCGGTGGTGGAATGATTAATCCTCTAAATGAAAGACCATCACCATTCCAAAATTTGAGTAACAATTCGatattaaacaatttcaaaacaCCATGTCAGGTAAAGTCTGAGGAAATGACACCCGTTAATGCTGAACAAGCATTCACCGAACCCAGCACGGTACCTCAAGCAAAAAATGATTTGGTGCAGTCGCCTAATTCGGTAAAAATGGTGATTAAGAATGGAGTTTTGATGCCAAAACAAAAGCAGAGGAGATACAGAACGGAAAGGCCCTTTTCGTGCGAACACTGTTCAGCAAGATTTACTCTCAGATCAAATATGGAACGACACATCAAACAACAACACCCACAGTTTTGGTCGCAGAGACAACGCTCCAATATCGGTACCGGAGGAAGAAAAAACTCCACTCTAACAACAAATTTGCACATTCCGAGTTTTGAACAACCGAAGAGTCAAGACTACGAGGAAAACAAATCGAATCATATCtccgataaaattaaatatgccatATTAGCTCAACACTTAAGGAGTAATCAAGAGTACAAAAACACTGTAATgccaaagaaagaagaagatgACGAATGCGCTTTAGTCATCGATGAGAATGAATCCAAACAGGAGAAGTTAGAAGAAAAAAAGCCGTTGTGCGAAAATGAAAACCTGGATGAAACCCGTGAAAATCACATGATGCCCAAACTTGATAGTTTACTTTCCAATAATAAGCCGTTTAAACATGATGAAACTCAAGATTTAGTATCTGTGTCGCGCTTGCTAGATAACGCGTCTCAACAGCAATTTAAGGAATATTTCAAAAGAGAAGGGGAAGAACCGGACGGAGAAGGTGGAAGCGAAGAAGACGAAGAAGGTCTAGTTGCTAGTTGTAGCACCAGCGAAGCGAATTCTGGGACTGATGAGAATAAaTCAGAATCTGAGACTCTATCCGCTCAAGGTCCTGTTAAAAAGAAATCGGCGTATTCATTGGCACCTAATAGAGTTAGCTGCCCCTATTGTAATAGAAAGTTTCCTTGGACCTCATCTTTGCGGAGGCACATCCTCACACATACAGGACAGAAGCCGTTCAAGTGCAGCCATTGCCCTTTGTTGTTCACAACAAAATCGAACTGTGATCGCCACTTACTGCGCAAGCACGGTAGTTCGGCAACGACAATCTCAAATGAACCCAACAGCAATAACGCTAGCTACTTGATGCGGAATGTTCCGGAAAGACCTTATAAATGCTCGAATTGCCCGAGTAGCACTTTTTCTACGTACTCTAATTTAAAGAAGCACATGAATTGTAAACACGTCTTGTCAAATGATGATAAAGCTCAAGGGTACGAAGCCGGAAGTTCTGAGGATGAGAAACAAAATAACCACGACCACCTCCCGGAGTGGAATCCGCAGCTTTCCAAAATAGCACCAGGCGATAATCAAAATACCCAAACAAACTCGGACTTGCCATTTAAATGTCATCTATGCGAAGGATCTTTTGGCGAGAGGAACGATTGCCTCGAGCACATCAAAGACAAACATCCTTCCGAATATGAATTGTTGATGTCCAAGAACGCATTAGATAACAACGTTTCAACGCCGGAGGAGTCGACGAATCACGAGGAAGACGAGAATGAAGTTCGTGGAAAATTTCCAGACTACTCGAATAGAAAAGTCATCTGCGCGTTTTGCATGCGTAGATTTTGGTCCGCCGAAGACCTAAGGAGACATATGCGAACTCATACTGGTGAGAGGCCCTTCAGCTGCGATATATGCCGCAGGAGATTCACTTTGAAACATAGTATGTTACGTCATAGAAAAAAACACAACTTATCCTTCGATAACGACAATCTTAACAGCGACGAAGATAATGTAAGTCCTTTCTTGGGTAAGATGAATAATATTGCCATGAAAACCTCGGACAAAACGGACGAATCCGACGGAAACGAAGGCAACGATTTAATTAGCAACCTATTGGGAATCCAGGATAGATCGATCATTGAGCAAGTGTTAACGGCATCGCCAGATGATGCAGCAAAACTATTAGGAGTTAAAAATGGCAGTCAAGATTAG
Protein Sequence
MQGIVFMPHNLETGSPPLHKDTDSNENMDTITTEPNIIHTKEPPVNQSSRSDSGFLSITNNTTYPDSEERTHQDNGDTDNRSDCSSPDGRKYYCPICERMLTSQHEFTLHIRSHNNDSDSQCQDKGFVCRICSKVLSSSSSLDRHVLVHSGERPFTCKYCGDTFTTNGNMHRHMRTHSFKNDYESDGSTDSSSSSNSKTVEYNNNKVERYEKRKLALCENYKNARIKLEDDDGNGDKYKCPVCERDDFASKTNLEIHLEDNHPDFPAKCQECNSTFKNNKLLAMHKAAAHEECGKHRNSVVGFKDLTFVDFSSEKFPHIARHECEKNLHKASSGLRFQCQKCSRAFPCANSLEIHQRGCSVGVDLSVTNENSMNLTKSPTLNENDVKRADFFSRLDLQDNSPEKNEFDGSKLQQKLLETVNLDNSNNKDLADIQSIISMTRNGSFLQHLQTKGDMPNHQAAPDLQLEKTEEEEAQDVFAKEFRKMKLRGEFPCRLCSAVFPNLRALKGHNRAHLNGNTNGTYRCNMCPHASVDKAALIRHMRTHNGDRPYECSLCNYAFTTKANCERHLRNRHAKTTREEVKKSIIYHPSEDPTNDDINKLVIREDIRKINSSFNSTESTEISPEKLRSSTPKMHPSDLFGSHNEPNPLIPIPTQVTSWRTSFIDTSPVKSIQETKIKTEMPYLQQLTFMPKSDNVSTPQKSVPKIHVKNLDRLKQTEYECNEDEKYEHYPDDEPMDLSKKKTPEIEAASDHNNDETPEDLSSKKPNLTPFNMTEILTQQLLMKNTPVDPTSFYAAQLAFCNSFSGWSPFSPITPLLFQNPILPQEQEMKRLQRQLCGGGMINPLNERPSPFQNLSNNSILNNFKTPCQVKSEEMTPVNAEQAFTEPSTVPQAKNDLVQSPNSVKMVIKNGVLMPKQKQRRYRTERPFSCEHCSARFTLRSNMERHIKQQHPQFWSQRQRSNIGTGGRKNSTLTTNLHIPSFEQPKSQDYEENKSNHISDKIKYAILAQHLRSNQEYKNTVMPKKEEDDECALVIDENESKQEKLEEKKPLCENENLDETRENHMMPKLDSLLSNNKPFKHDETQDLVSVSRLLDNASQQQFKEYFKREGEEPDGEGGSEEDEEGLVASCSTSEANSGTDENKSESETLSAQGPVKKKSAYSLAPNRVSCPYCNRKFPWTSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGSSATTISNEPNSNNASYLMRNVPERPYKCSNCPSSTFSTYSNLKKHMNCKHVLSNDDKAQGYEAGSSEDEKQNNHDHLPEWNPQLSKIAPGDNQNTQTNSDLPFKCHLCEGSFGERNDCLEHIKDKHPSEYELLMSKNALDNNVSTPEESTNHEEDENEVRGKFPDYSNRKVICAFCMRRFWSAEDLRRHMRTHTGERPFSCDICRRRFTLKHSMLRHRKKHNLSFDNDNLNSDEDNVSPFLGKMNNIAMKTSDKTDESDGNEGNDLISNLLGIQDRSIIEQVLTASPDDAAKLLGVKNGSQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00627621;
90% Identity
-
80% Identity
-