Basic Information

Gene Symbol
-
Assembly
GCA_012274295.1
Location
NW:3430316-3431319[+]

Transcription Factor Domain

TF Family
HMG
Domain
HMG_box domain
PFAM
PF00505
TF Group
Other Alpha-Helix Group
Description
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 1.6 6.5e+02 0.0 1.2 42 59 5 22 2 30 0.76
2 5 4.2 1.6e+03 -1.3 0.7 50 69 47 66 44 66 0.85
3 5 1.7e-09 6.6e-07 28.8 1.3 6 60 84 134 82 143 0.88
4 5 5.5 2.2e+03 -1.7 0.1 46 59 138 151 132 158 0.74
5 5 8.2 3.3e+03 -2.2 0.2 49 61 163 175 150 181 0.55

Sequence Information

Coding Sequence
ATGAATTCCAGTATggacaaaaatacaaaacaaaCCTACGAAGATTccaatgaagaaaataaaaaaaatgagacAAGTAAAGAATATGAAGTGGACTTCATTAACCATGCGCAAACGATACGTGAATctgatttaaattataaatctaaaCAAAATAAGATGAATTCACAACATAATCAACGCGAACGTAATTATTCCCGTTCTCGTTCACCGAACAGTACCAAGAGCTCTAAAAAATGGATAAGCTCTAATGCCTTTATCAATTTTGTACAGGACTTCAGACAGAAttgtagaaatgaaaagagtacaaaaatatttcaattagcTGGGGAAAGATGGAGAAAAATGTCTTTTGAAGAAAAGCAACCATACGTAAATGAAGCTCTGAGTGTTAAAAATCAAAGGGTTCCACAGAaaagtaaatatataaataaacttcaAACAAATACAGAATCAACAAAAAACGAAAATATACCTAAACAAgagaaagtaaataaaaaatcagaaagaaataaaaaggaACCCAATAAAGAGACTAAAAAGGCAAGTGATACTGAATCAGACAGTGGTTCAGCCACCTCAGGTACAGCAGGATCAGCAACAAGCGAGGATATGTCAGATACAAGTTAG
Protein Sequence
MNSSMDKNTKQTYEDSNEENKKNETSKEYEVDFINHAQTIRESDLNYKSKQNKMNSQHNQRERNYSRSRSPNSTKSSKKWISSNAFINFVQDFRQNCRNEKSTKIFQLAGERWRKMSFEEKQPYVNEALSVKNQRVPQKSKYINKLQTNTESTKNENIPKQEKVNKKSERNKKEPNKETKKASDTESDSGSATSGTAGSATSEDMSDTS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01122417;
90% Identity
iTF_01122417;
80% Identity
-