Basic Information

Gene Symbol
UBTF_1
Assembly
GCA_004796505.1
Location
SSSI01009910.1:12331-14591[+]

Transcription Factor Domain

TF Family
HMG
Domain
HMG_box domain
PFAM
PF00505
TF Group
Other Alpha-Helix Group
Description
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 4.9 3.7e+03 -1.5 0.0 36 48 79 91 75 95 0.78
2 6 4.2e-17 3.1e-14 53.2 3.6 2 66 129 193 128 195 0.96
3 6 3.2e-08 2.4e-05 24.7 4.2 1 69 218 284 218 284 0.94
4 6 9.2e-07 0.00068 20.0 2.2 2 68 316 380 315 381 0.92
5 6 1.3e-05 0.0096 16.4 3.0 36 66 457 487 455 490 0.90
6 6 2.5 1.8e+03 -0.5 0.8 40 60 491 511 487 519 0.83

Sequence Information

Coding Sequence
ATggatatttcaaatataaaacaagaagAATTAGATATTCCTCGAGAAACCAAACGTACTTTAGATAATGGTGTGAAAAAGGAGCTCATCAACTGGCCAGATGAAGATTTACTGGAACTGATACGTAGAATGGAAAATTCAATACCTGAGAATGACAATCTATCGTACGGCACAAGGGCTGAGAAGCTAGAATGGGAAAATattACTTTCAACGATTATTCCACAGAtgattgtaaaaaaatgtggAGTCTATTGCAGAAAAAAGTGCGCCGTTATAGAACATTAAACGAAGTTTTAAATGACACTAAAGATTGGATTGAATTACGTCAATTAAAacgtaaaaagaaaattaaaagtacAGAGAAAtcgaagaaaattaaattgaaacatCCTGATACGCCGTTTTTGTGTTTCTATCGTGACAAAAAGGAGGATCTTAAGAAGGACAATCCTGATATGCCACTCtccgatataatgaaaaaaaccAACGAATTGTATAAACTTGTATCGGCAGAAGAAAAAACCAAATACGCTCAAATGGCAGAAGAAGCCAAAAAggagtataataaaaaattagagGAAATGCTAGAATCAAATCCGAATTTTCTCGAAgagaataaaacaaatattaaaaaaattaaagatagAATACCTAAAAGGCCACGTACtccattttgttattattattcatcagaaataaataaattgaatataccTAATGCAGAAAggaataaatttaaagaattatGCAAAACTAAATGGAAACAATTGTCTGATAAAGCAAAAGTTCCATGGATAAACATGACAGAAAAAGAAATGATTAAATATACCgATGCTATTAATAACTATAAAAAAGACCATCCAGAATATAAAGCTCATCccgttaaaaaattgttaaccaAAGAAGAAATGCATATAAAACAACGAATGGCTGGTAAACCATTAAAACCACCACAGTCTGCATATAGTTTATTTGCTagtgaattattaaatagttcacaaattaaaaatattccagTAAAAGAACGTTTACGTTTCGTTTCaaatgaatggaaaaaaatgtctgaaatagaaaaagagaaatataaaacaactgttaatacaaaaatggataaatataaacaagatTTTGCTAATTATTTAAAGACATTGCCAGAAGAACAGCGCCAAGCGGAAATGTTAAATAATGCACCTAAACGTAAAGTACCgcaaaaaaatgataataaacctacaaagataaaaaataaaattaaaattaaggaAGAGAAAGACgataaaacacaaataaaaaaatttgaggAACCAGAACAGCCACCGATTTCTGCttacaaatattttctaaCAATATACAAAGGATCAGATCCACCAGCACAGAAATGGAAATCGTTGAGtagtaaagaaaaacaaaagtaCGATGATGAATTAATGCAAAAGAAAAGGCAATATATAACTGATTTCGAAGCATTTTTGAATAGTTTAAGTAAAAGTGAATTGGAAGAGTACTCTAAATTACGAAAGAAACAAAAACAGGATCAagacgatgatgatgaagaGGAAGATGAGGATGAGGAAGAGGACGATGAGGAAGATGACACTGAAtaCAGCGGTAGTGGTTCGGAATCAGATTAG
Protein Sequence
MDISNIKQEELDIPRETKRTLDNGVKKELINWPDEDLLELIRRMENSIPENDNLSYGTRAEKLEWENITFNDYSTDDCKKMWSLLQKKVRRYRTLNEVLNDTKDWIELRQLKRKKKIKSTEKSKKIKLKHPDTPFLCFYRDKKEDLKKDNPDMPLSDIMKKTNELYKLVSAEEKTKYAQMAEEAKKEYNKKLEEMLESNPNFLEENKTNIKKIKDRIPKRPRTPFCYYYSSEINKLNIPNAERNKFKELCKTKWKQLSDKAKVPWINMTEKEMIKYTDAINNYKKDHPEYKAHPVKKLLTKEEMHIKQRMAGKPLKPPQSAYSLFASELLNSSQIKNIPVKERLRFVSNEWKKMSEIEKEKYKTTVNTKMDKYKQDFANYLKTLPEEQRQAEMLNNAPKRKVPQKNDNKPTKIKNKIKIKEEKDDKTQIKKFEEPEQPPISAYKYFLTIYKGSDPPAQKWKSLSSKEKQKYDDELMQKKRQYITDFEAFLNSLSKSELEEYSKLRKKQKQDQDDDDEEEDEDEEEDDEEDDTEYSGSGSESD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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