Basic Information

Insect: Oryzaephilus surinamensis
Gene Symbol: PAX6
Assembly: GCA_004796505.1
Location: SSSI01006403.1:3893-9681[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.7e-31 7.6e-28 97.0 0.1 65 125 51 111 37 111 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.7e-31	7.6e-28	97.0	0.1	65	125	51	111	37	111	0.96

Sequence Information

Coding Sequence: ATGATCTTTTTAACTCTGAAACAGCTGCTTTTCATCTTGATGTATTTGGGCTTAATATTGTTGAAGCGgtccatatatttatatgcattgaagaacaataaatatgtacaatctATACAACATCTGCCATCATCAAgaACTTTACGACCACCAGGCTTGATTGGAGGCAGTAAACCGAAAGTGGCAACGCCGGCCGTCGTCTCAAAAATTGAACAGTACAAAAGAGAAAATCCTACGATTTTCGCATGGGAAATTCGAGAACGATTAATATCGGAAGGTGTTTGCACAAACGCAACTGCCCCATCAGTTAGTAGCATCAATAGAATACTTAGAAATCGGGCCGCTGAACGGGCAGCCGCCGAGTTTGCCAGAGCAGCCGGCTACGGATTGTACCATCATCATCCGTATGCGGCGGCGGCGGCCGCCTTCCCATGGCATTCGCCCCTTTGGCCCAACGGACCGTTGGGTCTTCAACCACCTGGTGCTGCCAGCTCCTCAGTGATGGCCGGCTCACCCGCCTCCTCGGGTTCACCACATCCCGACCACGGTCTTTTGAATTCCCCACCCGGCGGACATTTAGACAAAGACGATTCCAGTCTGGACAGTTCTGAACAGCCGAAATTTCGCAGAAATCGCACCACATTCAGTCCAGACCAACTGGAGGAGCTGGAGAAGGAGTTTGAGAAGTCGCATTATCCGTGCGTCTCCACCAGAGAACGATTGGCGTCGAAGACGTCGCTGTCGGAGGCCCGCGTTCAGGTTTGGTTTTCCAACAGACGAGCCAAATGGAGACGGCACCAGCGCATGAATTTGCTAAAACAGTCGTCGCCGGGGCCGCAGAACAGCCAGTCTTCGATGTTCGGCGGCCGCTTGACGCCCTCACCGCATTACAAAGCCGCTTCCACCCCTGGCTCGCCGCTTACTACGCATCATCTAAACACCGGTCCAGCAGCTTCCTCGCTCCTACTGCAGATGGGCGGCGAAAATAGCGCCTTCAAAGCGTTAGTGCCTAATTCGTTGTTGGCTTCGCACGAGAACATGCGTCGATTAAGTGATTATGCGTCGGATTCGGAGGAGGAAATTAATGTTAACGATGAATCGGATGTGGAAGAGACGACTGAAAGGCAGAGGAGGTCTAGGTCTTCGAGTCCAGTGGAAGTAGTTGATTCACCGCCAAAAGAACCGCCTACATGTCAACCTTTACAACTCACAGTACACGATCGTGATTAG
Protein Sequence: MIFLTLKQLLFILMYLGLILLKRSIYLYALKNNKYVQSIQHLPSSRTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYHHHPYAAAAAAFPWHSPLWPNGPLGLQPPGAASSSVMAGSPASSGSPHPDHGLLNSPPGGHLDKDDSSLDSSEQPKFRRNRTTFSPDQLEELEKEFEKSHYPCVSTRERLASKTSLSEARVQVWFSNRRAKWRRHQRMNLLKQSSPGPQNSQSSMFGGRLTPSPHYKAASTPGSPLTTHHLNTGPAASSLLLQMGGENSAFKALVPNSLLASHENMRRLSDYASDSEEEINVNDESDVEETTERQRRSRSSSPVEVVDSPPKEPPTCQPLQLTVHDRD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01567840;
90% Identity: iTF_01121409; iTF_01163085; iTF_01162913; iTF_01226861; iTF_01226440; iTF_01014072; iTF_01014408; iTF_01013305; iTF_01013164; iTF_01567840; iTF_01567660;
80% Identity: iTF_01121409;