Ogra021761.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Orthosia gracilis
Gene Symbol
PAX6
Assembly
GCA_947562075.1
Location
OX387271.1:12608432-12636365[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.8e-35 1.3e-31 109.9 0.0 23 125 43 140 32 140 0.92

Sequence Information

Coding Sequence
ATGGAACATAGAGTTGAGCGATATTTACCTGTATCCCCTTCATCATCGGGCGGAGGCGCGGGCGGCGGGGCGGGCACCCCCTTGTACCCCGGGGCCGCGTCGCACCCCCTCTCGTCCCTACTGTCCCAACAGAGGCTGTTGGAGCTGTCCCGCTTCGGGCTACGGCACTATGACATCGCGCACCATGTGCTGTCACAGCAAGGTGCTGTAACCAAGTTGCTTGGCACTCTCCGGCCGCCGGGTCTGATCGGAGGCAGCAAGCCCAAGGTGGCTACCCCTGCAGTCGTCTCCAAGATCGAACAGTACAAACGAGAGAACCCCACCATCTTCGCCTGGGAGATCCGGGAACGACTTATATCTGAAGGTGTCTGCACGAACGCGACGGCTCCCAGCGTATCGTCCATCAACAGAATACTTCGCAACAGGGCTGCTGAGCGCGCGGCGGCTGAGTTTGCCCGGGCGGCTGGCTACGGGCTGTATGCTGCTCCTCCACCTTACGGCGCCTTCCCTTGGGGTGGCGGCGGTGGCGTCTGGCCTCATGGCTCCCTGCCTTTGCCCCCCGGAGTATCTGGTCCTCCGTCAGGAGTACCACACCCCGACGTCAACCAAGGATTCCTTTCATCTGGACGAGGACTAATCGACGTAGACGGCGACGACTCCGGCTCCCTAGACGGAGAACAACCGAAGTTCAGACGGAACCGCACGACATTCAGCCAAGACCAGCTCGAAGAACTGGAAAAGGAATTCGAAAAATCCCACTACCCATGCGTCTCTACACGAGAACGACTGGCGTCCAAGACTTCGTTATCAGAAGCGCGAGTTCAGGTTTGGTTTTCCAACAGACGAGCCAAATGGAGACGCCACCAGCGCATGAACCTCCTGAAGCGCGGTGGCGGCTCGCCCCCGCACCGCATGCCCCACTCCCCCTCCCGCTCCCGCTCGCGCTCCCTGTCCCCCGCGCGCGTCTCATACCACACCCCGCAGATGGGCGGCGAGAATAGCGCCTTCAAGGCTCTCTCGCACCAGGATACCAACGCCCTGAAGGCCTTCGCTCACCAACAGTTCGACGCCAACGCACTAAAAGCGCTGTCGCAGCAGACGAATTTCGATGGAAGCGCTTTTAAGCCTCATCCTGCATTAGAGAACAGCGCGTTTAAATCGCTCGTACCACATTCAGCGGCTGCAGCACTTCTGGCGGCGCAGTCCATCCAGCTGGCGCGGGGATACGAGTCGCACTCGGACTCGGACGAGGAGATCAACGTGCACGACGAGAGCGACGGCGAGGAGCGACGATCGGCGTCGCCGTGCCGGCCGCGCGCCGCCGCCAGCGATCTGCCGCTACAACTAACTAAACATGATCGTTGA
Protein Sequence
MEHRVERYLPVSPSSSGGGAGGGAGTPLYPGAASHPLSSLLSQQRLLELSRFGLRHYDIAHHVLSQQGAVTKLLGTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYAAPPPYGAFPWGGGGGVWPHGSLPLPPGVSGPPSGVPHPDVNQGFLSSGRGLIDVDGDDSGSLDGEQPKFRRNRTTFSQDQLEELEKEFEKSHYPCVSTRERLASKTSLSEARVQVWFSNRRAKWRRHQRMNLLKRGGGSPPHRMPHSPSRSRSRSLSPARVSYHTPQMGGENSAFKALSHQDTNALKAFAHQQFDANALKALSQQTNFDGSAFKPHPALENSAFKSLVPHSAAAALLAAQSIQLARGYESHSDSDEEINVHDESDGEERRSASPCRPRAAASDLPLQLTKHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01118090; iTF_00036454; iTF_01342051; iTF_01342189; iTF_00049871; iTF_00036659; iTF_00049728; iTF_00185283; iTF_00186149; iTF_00185967; iTF_00185145; iTF_00837508; iTF_00834608; iTF_00837299; iTF_00834456; iTF_00326917; iTF_01259910; iTF_00327051; iTF_01260075; iTF_00809093; iTF_00808936; iTF_00810034; iTF_00809888; iTF_00784365; iTF_00784230; iTF_00785165; iTF_00785035; iTF_00685262; iTF_00685410; iTF_01221519; iTF_01221323; iTF_00237296; iTF_00237541; iTF_01230545; iTF_01230343; iTF_00043316; iTF_00043461; iTF_01085172; iTF_01084971; iTF_00425205; iTF_00425350; iTF_01084085; iTF_01084227; iTF_00973754; iTF_00973557; iTF_00001147; iTF_00001015; iTF_00037787; iTF_00037604; iTF_00726331; iTF_00726116; iTF_00850428; iTF_00850711; iTF_00783262; iTF_00783438; iTF_00039775; iTF_00039625; iTF_00042463; iTF_00042603; iTF_00851776; iTF_00851553; iTF_01030183; iTF_01029988; iTF_01527147; iTF_01525761; iTF_01525988; iTF_01526848; iTF_00935701; iTF_00935508; iTF_00018010; iTF_00018137; iTF_00932493; iTF_00827813; iTF_00827930; iTF_00932250; iTF_00355123; iTF_00354916; iTF_00621971; iTF_01073584; iTF_00621853; iTF_01073437; iTF_00821786; iTF_00821610; iTF_01564383; iTF_01564625; iTF_01117005; iTF_01117185; iTF_00373740; iTF_00448849; iTF_00374066; iTF_00449078; iTF_01424877; iTF_01425036; iTF_01362318; iTF_01362408; iTF_01362926; iTF_01363084; iTF_00071409; iTF_01092897; iTF_00121411; iTF_00124067; iTF_00924419; iTF_01094727; iTF_01340071; iTF_00667433; iTF_01093866; iTF_01094890; iTF_00121227; iTF_01093067; iTF_00667181; iTF_00123182; iTF_00745456; iTF_01339792; iTF_00924631; iTF_01094010; iTF_00071231; iTF_00124223; iTF_00745664; iTF_00208853; iTF_00208659; iTF_01246871; iTF_01246657; iTF_00120318; iTF_00120483; iTF_00111633; iTF_00111438; iTF_00858514; iTF_00858379; iTF_01119125; iTF_01119305; iTF_00711830; iTF_01063585; iTF_01534626; iTF_00446948; iTF_01533765; iTF_00447112; iTF_01534795; iTF_00928492; iTF_01063725; iTF_00444943; iTF_01062769; iTF_01533905; iTF_00928658; iTF_01061714; iTF_01061842; iTF_01531794; iTF_01531987; iTF_01064468; iTF_00445142; iTF_01064634; iTF_01062587; iTF_00711648; iTF_01029240; iTF_01029047; iTF_00771705; iTF_00771893; iTF_01361466; iTF_01361591; iTF_01441018; iTF_01440815; iTF_01027131; iTF_01027290; iTF_00951804; iTF_00951625; iTF_01332604; iTF_01332376; iTF_00302078; iTF_00301927; iTF_00677374; iTF_00677588;
90% Identity
iTF_00018010;
80% Identity
iTF_01118090;