Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0092 50 4.7 0.1 22 48 43 69 33 75 0.82

2 5 0.017 89 3.9 0.2 23 45 72 94 68 97 0.88

3 5 0.00013 0.71 10.6 0.3 21 48 98 124 94 127 0.87

4 5 0.014 76 4.1 0.1 21 44 126 149 123 154 0.91

5 5 9.3e-05 0.5 11.1 0.1 20 48 153 181 150 185 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0092	50	4.7	0.1	22	48	43	69	33	75	0.82
2	5	0.017	89	3.9	0.2	23	45	72	94	68	97	0.88
3	5	0.00013	0.71	10.6	0.3	21	48	98	124	94	127	0.87
4	5	0.014	76	4.1	0.1	21	44	126	149	123	154	0.91
5	5	9.3e-05	0.5	11.1	0.1	20	48	153	181	150	185	0.90

Coding Sequence: ATGGATTCAGAACTACTGGACGATCTTTGCAAACAAATATACACTTGTCGTCGTTGTAAGCAGacTTTTACTTCCAAGCACGACCAACTGATGCACAAGAAAGAGAAGCACGACCATAATCCCGCCGAAAATAGTTACATTTGCAATTTGTGCCAAACAACGTTTGCCAATCATGGTAACCTTGAGCGTCACATGAAAGTTCATAATGATGTCCGACCGCATATTTGTGGCGAATGCAATAAGTCATTTGCACAGGCTGTTAACTTACAACGTCACTACTCCGTGCACAGCGGCGAGCGTCCTTACCAATGTCAGTTGTGTGAGAAATCCTTCACTCAACAGGGTAATCTGCGACGCCATGAACTGATCCACACCGGCGAGAAACCATTTCAGTGCGAACGATGTGATCGTTTGTTCTCCCAGCGTATTAATCTAAAGAAGCATATGATGGCCCACCAGGGTTATCGGCCATTTGTTTGTGGCGTATGCCAAAAGTCTTTCATACAATCGCAGAACTACAAGAAGCATCTGAATAAACACCACAAGGAAATGGCCCGACAAGAAGCGGCAGAGGCTGCTTTGGCAAAGGTTAAAATAGAACAACCACTaaTGTATGGCGTGGCGTCAGATAAGGTGAAAATGGAACCATTTCGAGTGTATGAGTGCGGAGGATGTCGGATAGTATTCGGACAAGAGTATAACGGCGAATCGAGTGGCTTAGTCAATGCCGCATCCATTATGGAACACAGTCATAGTCGCGGGTAA
Protein Sequence: MDSELLDDLCKQIYTCRRCKQTFTSKHDQLMHKKEKHDHNPAENSYICNLCQTTFANHGNLERHMKVHNDVRPHICGECNKSFAQAVNLQRHYSVHSGERPYQCQLCEKSFTQQGNLRRHELIHTGEKPFQCERCDRLFSQRINLKKHMMAHQGYRPFVCGVCQKSFIQSQNYKKHLNKHHKEMARQEAAEAALAKVKIEQPLMYGVASDKVKMEPFRVYECGGCRIVFGQEYNGESSGLVNAASIMEHSHSRG

Sequence clustering based on sequence similarity using MMseqs2