Basic Information

Gene Symbol
hang
Assembly
GCA_963555765.1
Location
OY743224.1:49869893-49878105[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.041 4.7 8.4 1.3 3 23 248 269 247 269 0.93
2 17 0.066 7.5 7.8 2.6 1 23 439 462 439 462 0.91
3 17 0.0015 0.17 12.9 1.7 2 23 569 591 568 591 0.95
4 17 0.017 2 9.6 0.1 1 23 599 622 599 622 0.95
5 17 2.8e-05 0.0032 18.4 0.1 2 23 720 741 719 741 0.97
6 17 2e-05 0.0022 18.9 2.5 2 23 785 807 784 807 0.96
7 17 0.0028 0.32 12.1 0.2 2 23 816 838 815 838 0.95
8 17 0.001 0.12 13.5 0.2 1 23 851 874 851 874 0.97
9 17 0.00032 0.036 15.1 1.0 1 23 902 924 902 924 0.99
10 17 0.0014 0.15 13.1 0.9 1 23 932 955 932 955 0.96
11 17 0.0079 0.9 10.7 0.2 2 21 963 982 962 983 0.92
12 17 0.00026 0.03 15.4 0.3 3 23 1042 1062 1041 1062 0.97
13 17 6.1e-05 0.0069 17.3 0.2 1 23 1097 1119 1097 1119 0.98
14 17 6.3e-05 0.0072 17.3 0.2 2 23 1144 1166 1143 1166 0.93
15 17 0.12 13 7.0 0.6 2 20 1186 1204 1185 1206 0.91
16 17 0.0032 0.37 11.9 0.5 3 23 1221 1241 1221 1241 0.98
17 17 0.0017 0.2 12.8 0.8 1 23 1376 1398 1376 1398 0.97

Sequence Information

Coding Sequence
ATGACAGAAGAATCAATATTACGTGCACGTCAGAATTGCTGTCGCTTGTGCTTGGCTCCGGATAGTGAATGTATTTCGATTTTTAACAGCTATGCGGCTGATAAGGAGCCCCTGGCTACTAAAATCCAATATTGTGTCAATATTAAGGTGTCGCCGATTGACCGGCTTTCGCTGCGAATATGCCACGCTTGCATCAGTTACTTGAACTCATGGCAGAGTTTCAAAAACCGTTGTGTTGCCTCACAAAATAAACAACGCAGCTGGCTGGAGATatcgaagaaaattgaaaagaaacaaattggCTCGGCAATTCCTCTATCTGCTGGACCAGTGGGTGGGGGAATTCCCAATGAAGATAAAAGCGAGGACCGGGAAAACAACCCGCTTGCCTCAtcaattttagaagaaatttcATCGCTTAAAAAACGCCGTTCTTTAACGGTTTACCCAATTCCGGTGAGTGTTAAGGACGAACCAATGGATGACGAAGACTATGATTTAAAACATGATGAATCAGATATAGATCCTACGCTTTTCTTAGAACGCAACGAAGAGGAGTGCTCGGACAATTTGTCGCAAAAGGAACAACATTTGGCGTCGCTTGGGTTGAAACAAGCGTCGAGTGCCATTCACCCATTAAACTACTTGgctGATTATAGTTTTGATGGTGACAAAACCCAACCTTCTGTGGACAAATCTTTGGAAATCACTGCAACTACAAATGAAGTAAAAGAAGCATCATGCCGCGCttgtaatttaaagttttccacAAGGGCCAACGCTCGTCGCCATGAGCGTAATCTTCATCCACATCTTTTTACAAGCGTTACCATGGGCACTGCAAATCCCAAAGGACTAAGTGTTGTTCCGCCAATGCAGCACTCAATCAAGAGCGCGCCATCAATTCGGCCAGCAATCAAACCAGAACAACTAGGCCTCTTCGATTACGATCAACCCGAAAAGTATCAGCAACTCCTTACCGAGGACAAAATAATGTTCATGCAACGTCACGACGATTTCCTTCAGCAATATCAAAATATGACCTGCAACTGTTGTCTGCGCACGCATGCAActtacaaaaactttatggcACACATGCGAAAGAAGTATCATTCTTTGCCACGCAATTTATGCTTCAAGTGTCTCAAGCAGAACGATTCGAAGGCGTTATTTATTTCGCATCTAAAGAAGCGAAATTGTATTAATCTGTACAAAATTTACCAAAGCCTAGTCGATGCAGGTGTGATGAAAAAAGACGCAACCAGTTGTTCTCCCGACAAGCTGCGTGCCAAAGAACTGCTCGTGAACAAAATCTATGAATGTAAAATATGTTCAAAGCACTACCGTCTAAAGCTTGAGTTCCGCAGCCATGTCTATGAGGAGCATGCAGATTATCAGAAAAAAGACGTCTCTCCAGGACACTGCGGATTCTGTGGCTTAGAGATTGAAGATCCGTTTGAGCGGAAGCGCCATTACAACAACATGGACTGTATTGTCATCCTTCGCTGCATAACGTGCGAGGAAAAATTCGACAATCACCAGAAGTTTCTAGACCATGTGTACTCAAAACATTTGGCTAAcaataatgaaattcaaaagagTAACTTGATGAAGGAACTCTCAACGACAACCTCTACAGAGAGTTCGCCTTCGAAGAAGTCCGAGACACCTGCGAAGCCACAGTTCTTTTCACGCCTACCTCAAAGCTGCAATATTTGCGGTCAACATTACAATAACTATAACAATGTATTACGCCACATGGAGTCCAAGCATCCGGATCAATTGCCTCAAACGTACAAATGCACTCGGTGTCTCGTTGGGTATCCCCGTCTAATGAATCTCCGCGAGCACATGATCGAGGTGCACGGCATGAAGGTGGACAAAGTGCGCAATAATAGCTTTGATTACATTGTTGATTCGCCAACCGTACAAGGAAACGTACCGCGAGGTGGCGAAAAAATGGTGGCCGACGCATACACTGGACGCTATGATTATGTTATGAAGGATCTGATGTCTATAACAAATGGCGGGACGATCGGAAATGATGGTGCCAATGATAACGAGGATGATGGCAATCAATCAGATTCGCCGCCGACTGCAAAGAAGTTCAAACTAGAGGGCGGCGCAATGGTAACAATTGGCACGGCGAATTTGAAAGAATGCCCAATTTGCAGTGCagttttcaacaacaacattggACTGTCGAATCACATGCGTACGCATACTGCAGGAGATGGAGCTGGGGGTGAGGATGTTACTGCAAAAGCTGACGAGGCAGTCGAAAAGAAACCAATTGATCCGATGTTTAGGAGAAGTCTGGAATTAGCTGCTGACCGACGTTTTCGTCGAATGCGCTGTCGTATCTGTCAGAAACGTTTCTCATCAAAGAAAAGCTATCGCCGTCACATGTTGATTGACCACCAAATTCGCAATGTTCAGTTCATTAAATGCAAACTATGCGACGCTGAGTTCGCCTACGAGAAAGGGCTAAAGGTTCACATGTTCAAGATTCACAACACTCTGCTAAAGGACGAAATGATTGTTAAGCAATTTGAGTGCGATATTTGTTCGATTGTCTATAGGACAGAGGAACAGCTGTTGCTGCATAAGAAGTCGGTTCATGGCAACGAGACTGCCCAAGCCGAGGAAGATTTGCCGCAATCTATGGACCAAAGTGTGGAGTCATTAGCGCCGCTTTACTGGTACCAGTGCCGATATTGCCCGTCAAACttcaatacaaataaaaagctTGCCATTCATATAAATTCACACTACGAATTCGATTCAAATGATTACTCCTGCAAGGATTGCGGAAATGTTTACAGCGGCAGGAAGAGCCTTTGGGTGCATCGCTACAAGAAACATCCTCCAGTCGCTGATCCTTCAGAGTGTAGtctttgcaataaaattttcttcgacAAACAAATGCTGGAGAACCACGCACAATCGTGCTCTCAGAAGCGAGCCGCGGGGCTTGAAACTGAGACAAGCAACATGTTTCAGCATAAAACCGGCGACGATGACGAGGCCAATGAGAATGAGCTCCAACAGCAGCATCCGCAACAAGAGAGCACTCTTGAGGACACTGCTgctaatttgaaaatcaaacttccCGAAGTGGCGTGCACAATATGCGCTCAGAAATTTACTGATCAAGATCTCTTCACAAAACACATCGAGATGCACGAAATGGAGTTATACACTGACAATCCACTGGCAGCCATGTTCGATACTGGTCCAGCTGATCCGAATCAGTTTTATTTGGATCGTGTTAACGATAATGGCGAGTATGTGTGCGACATATGTACAAAGGCTTTTGCGCAGATGACTGCGCTGAAGGTCCACCGCAAGTGGCATTTCCGAGGTGATAGCAAACAGACGCCAGCCGATGCAAACGCTCCAAAAGCAGCGAAACGAAAGCGTGAACTTAAATGCGATTACTGCCCGTCGACTTTCATCAGCTCAAACAACCTTCGACGACATATCGCGGAGCTGCACAAATCCGAAATATCCAATTGGCCCGAACCAccaaaaattgaagttgaaaagtACCTACATTGCAGCAAGTGCGACCTGAAGTTCGAATCAAAGAAAGACTGGattgaacacaaaataaatgaagCGAAAGTAGCCAAACCATTTGGTCCATTCCAATGGGGCTGTGAGATCTGTGGTATTTACTTGTCACGCCGCGAAAAGCTAATACATCACATGATGGCAcatattaaagaaacaaatggtCAACTGAGTGTAGAGGGTGAAAATTATCCAGGAGAAAGTAATTCACAAGATTCTGAGTCATCCAGCCATCAAGGTGCAGCCGAACAACGAACAGTGAATGAGGAAGACGACGAAGAGGAGGCtgaagaggaagaggaagaagaaTTTGATGGCGATGAGGAAGACGCCGAAGAAACAGTCGACAATGCTAATCATGACGACAATGCCAACGATGGACAAAATGAAGACACAACTGAACAACAATCACAACTGAGGCAACGGCTCGAACGTGAGTCAAACGATGATAGCAATGATTCGAGTGATCAAAGTTCCGATTCTGATGATTCCTCCTCTGAAGATGATGATGCAGAAACTTCCGTTCAACAGAAAGAGCTCGCAAAACGCTTCTCCTGCGATTTGTGTCAAGTTTACTTTGAGACCTCGACAGAACTTCAGAAGCACGTCACTAGTCATTTCCTAAACGGCCCGGGCTCGGTTACTCTAACCACGATCACAAAGGAGAAACCTAGATCTTCTGAGCCCAATAACAAGGACGACGAAGGCGATGGCGACGCTGACGAGgatgacgaagaagaagaagaggaagaagacgaagacgatgacgacgatATGACCGAAACAGATCAAACAGACTTCTAA
Protein Sequence
MTEESILRARQNCCRLCLAPDSECISIFNSYAADKEPLATKIQYCVNIKVSPIDRLSLRICHACISYLNSWQSFKNRCVASQNKQRSWLEISKKIEKKQIGSAIPLSAGPVGGGIPNEDKSEDRENNPLASSILEEISSLKKRRSLTVYPIPVSVKDEPMDDEDYDLKHDESDIDPTLFLERNEEECSDNLSQKEQHLASLGLKQASSAIHPLNYLADYSFDGDKTQPSVDKSLEITATTNEVKEASCRACNLKFSTRANARRHERNLHPHLFTSVTMGTANPKGLSVVPPMQHSIKSAPSIRPAIKPEQLGLFDYDQPEKYQQLLTEDKIMFMQRHDDFLQQYQNMTCNCCLRTHATYKNFMAHMRKKYHSLPRNLCFKCLKQNDSKALFISHLKKRNCINLYKIYQSLVDAGVMKKDATSCSPDKLRAKELLVNKIYECKICSKHYRLKLEFRSHVYEEHADYQKKDVSPGHCGFCGLEIEDPFERKRHYNNMDCIVILRCITCEEKFDNHQKFLDHVYSKHLANNNEIQKSNLMKELSTTTSTESSPSKKSETPAKPQFFSRLPQSCNICGQHYNNYNNVLRHMESKHPDQLPQTYKCTRCLVGYPRLMNLREHMIEVHGMKVDKVRNNSFDYIVDSPTVQGNVPRGGEKMVADAYTGRYDYVMKDLMSITNGGTIGNDGANDNEDDGNQSDSPPTAKKFKLEGGAMVTIGTANLKECPICSAVFNNNIGLSNHMRTHTAGDGAGGEDVTAKADEAVEKKPIDPMFRRSLELAADRRFRRMRCRICQKRFSSKKSYRRHMLIDHQIRNVQFIKCKLCDAEFAYEKGLKVHMFKIHNTLLKDEMIVKQFECDICSIVYRTEEQLLLHKKSVHGNETAQAEEDLPQSMDQSVESLAPLYWYQCRYCPSNFNTNKKLAIHINSHYEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPPVADPSECSLCNKIFFDKQMLENHAQSCSQKRAAGLETETSNMFQHKTGDDDEANENELQQQHPQQESTLEDTAANLKIKLPEVACTICAQKFTDQDLFTKHIEMHEMELYTDNPLAAMFDTGPADPNQFYLDRVNDNGEYVCDICTKAFAQMTALKVHRKWHFRGDSKQTPADANAPKAAKRKRELKCDYCPSTFISSNNLRRHIAELHKSEISNWPEPPKIEVEKYLHCSKCDLKFESKKDWIEHKINEAKVAKPFGPFQWGCEICGIYLSRREKLIHHMMAHIKETNGQLSVEGENYPGESNSQDSESSSHQGAAEQRTVNEEDDEEEAEEEEEEEFDGDEEDAEETVDNANHDDNANDGQNEDTTEQQSQLRQRLERESNDDSNDSSDQSSDSDDSSSEDDDAETSVQQKELAKRFSCDLCQVYFETSTELQKHVTSHFLNGPGSVTLTTITKEKPRSSEPNNKDDEGDGDADEDDEEEEEEEDEDDDDDMTETDQTDF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01254232;
90% Identity
-
80% Identity
-