Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6.4e-39 7.8e-36 122.6 0.0 1 85 55 138 55 140 0.97

2 2 2.5 3.1e+03 -1.1 0.4 32 49 200 216 186 217 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6.4e-39	7.8e-36	122.6	0.0	1	85	55	138	55	140	0.97
2	2	2.5	3.1e+03	-1.1	0.4	32	49	200	216	186	217	0.72

Coding Sequence: ATGGCTCCAATTTTCGAATCAAACTTCTCGATAAGGTCCATCCTGTCTGATACCTCAAGCAGTGGCAGCAATAGCGATGAGGAAAACCAGCAATACGAACACAACCATCGTCAACAACAGCACGAAGAGTTCCAGAATTCCAGTAGCGAAGAGGACTCCGATCAAAGACCACCATACACCTACAGTGCCCTAATTGTCATGGCAATACGCAACAGTCACAAGCGACTTCTTACACTCAACGAGATTTGCGCATGGATTGCCGACAAGTTTCCATTCTATCAAAAGAACAAAAGTACTTGGCAAAACTCAATTCGTCACAACTTGAGCATCAATCAGTGTTTCGTGAAAGTACCAAGGCCTTTGGATGATCCTGGAAGGGGACACTACTGGACCTTGGACCCATCAGCTGAAGATGTTACAATCGGTGCCACCACTGGTCGTCTGAGAAGAGGTGACCCCATTTCTGGAAATCAATATGCCTaccagcatcatcatcatcattaccaTCCACAAGTTCCAAGCACACCCTACGCCATGTACTTCCCAACTCCTGAAGAAGTCATGGCCATGCAGCAATCAGCAATCCAGGAACAACAAATGTGGAACAACTATCACTTAtaccaacagcagcaacagatcATGCAAAACACAGGCGCCTATATCGATGGTCCCATGGACTACcagtaa
Protein Sequence: MAPIFESNFSIRSILSDTSSSGSNSDEENQQYEHNHRQQQHEEFQNSSSEEDSDQRPPYTYSALIVMAIRNSHKRLLTLNEICAWIADKFPFYQKNKSTWQNSIRHNLSINQCFVKVPRPLDDPGRGHYWTLDPSAEDVTIGATTGRLRRGDPISGNQYAYQHHHHHYHPQVPSTPYAMYFPTPEEVMAMQQSAIQEQQMWNNYHLYQQQQQIMQNTGAYIDGPMDYQ

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00310819; iTF_00315747; iTF_00314954; iTF_01253349; iTF_00313256; iTF_00312398; iTF_00311613; iTF_00187859; iTF_00976261; iTF_00389427; iTF_00314075; iTF_01223197; iTF_00724574; iTF_00724575; iTF_01044542; iTF_01044543;
90% Identity: -
80% Identity: -