Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 1.1e-21 2.3e-19 70.3 0.1 10 79 1 68 1 81 0.90

2 4 2.1e-21 4.2e-19 69.4 0.2 4 88 86 168 83 172 0.87

3 4 6.7e-29 1.3e-26 93.5 1.4 2 109 168 276 167 277 0.93

4 4 6.8 1.4e+03 0.2 0.0 79 105 278 304 274 306 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	1.1e-21	2.3e-19	70.3	0.1	10	79	1	68	1	81	0.90
2	4	2.1e-21	4.2e-19	69.4	0.2	4	88	86	168	83	172	0.87
3	4	6.7e-29	1.3e-26	93.5	1.4	2	109	168	276	167	277	0.93
4	4	6.8	1.4e+03	0.2	0.0	79	105	278	304	274	306	0.83

Coding Sequence: ATGAGTGATGCATTACTGGTCGTAGGAAATGAGGAATTTCCAGTTCACAAAACGGTTCTTGCTGCTCAAAGTCCAGTCTTTTATGCGATGTTTAACAATAAcatgaaagaaaagaaggaaagaaGAGTAAAAATTGACGATGAAGATCCCGAAGTCATAAAGCAGCTGCTATTATACGTTTACACGGGTGATGTTGATGCAGATAACGTTAACGATGATCAAGctAATTCTAACTTTtcacaaaagtttaaaattttgttggaAAATGCAAATATGAGCGATGCATTACTGGTCGTaggaaataaagaatttcCAGTACACAAAATGGTGCTTGCTGTTCAAAGTCCAGTTTTTTATGCACATGTGTTTAACGATGAAATGAAAGAGAAGCAAAATAGAGTAGAAATCAATGATGTAGATCCTCACACCATGAAGCAGCTGCTATTATATGTTTATACGGGTGCTATTGATACAGATACTGTTAATAATGATGAAGctCTTAAAGCTTTTTTGCAAAATGCAAATACGAGTGATGCATTACTGGTTGTAGGAAATAAGGAATTTCAAGTACATAAAACGGTGCTTGCTGCTCAAAGTCCAGTCTTTTATGCGATGTTTAACAGTGAtatgaaagaaaacaaagaaaatagagTAGAAATTGACGATGTAGATCCTGAAGTCATGAAGCAGCTGCTACTATATGTTTATACGGATGATATTGATGCACATAGTGTTAAGAATGATCAAGctgtaaatcttttaaaagcagCTGATAAATATGCTTTAGAAGAACTCAAATTTATTTGCGCAAAAATAATCAGTAAAAATTTGACGATCGATAATGTATTTGCAATGATTAGCATGGCTGAACAATACAAACTCAATTATCTCAAAAAAGCCgcagcttattttattttttgcaattgcgACGATATCTTGAAATCTCCAGACGATTCTGATTTGACCATTacatcaatttcttttaaagaaaaaagtgttATTGAAACAgagcaaaaaatataa
Protein Sequence: MSDALLVVGNEEFPVHKTVLAAQSPVFYAMFNNNMKEKKERRVKIDDEDPEVIKQLLLYVYTGDVDADNVNDDQANSNFSQKFKILLENANMSDALLVVGNKEFPVHKMVLAVQSPVFYAHVFNDEMKEKQNRVEINDVDPHTMKQLLLYVYTGAIDTDTVNNDEALKAFLQNANTSDALLVVGNKEFQVHKTVLAAQSPVFYAMFNSDMKENKENRVEIDDVDPEVMKQLLLYVYTDDIDAHSVKNDQAVNLLKAADKYALEELKFICAKIISKNLTIDNVFAMISMAEQYKLNYLKKAAAYFIFCNCDDILKSPDDSDLTITSISFKEKSVIETEQKI

Sequence clustering based on sequence similarity using MMseqs2