Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.055 22 5.3 0.0 25 45 107 127 102 132 0.91

2 5 9 3.6e+03 -1.8 0.0 22 44 132 154 129 158 0.74

3 5 0.0009 0.35 11.0 0.2 14 43 152 181 141 186 0.83

4 5 0.0048 1.9 8.7 0.1 21 44 187 210 184 214 0.91

5 5 0.022 8.8 6.6 0.4 20 46 214 240 210 246 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.055	22	5.3	0.0	25	45	107	127	102	132	0.91
2	5	9	3.6e+03	-1.8	0.0	22	44	132	154	129	158	0.74
3	5	0.0009	0.35	11.0	0.2	14	43	152	181	141	186	0.83
4	5	0.0048	1.9	8.7	0.1	21	44	187	210	184	214	0.91
5	5	0.022	8.8	6.6	0.4	20	46	214	240	210	246	0.86

Coding Sequence: ATGGAAGCTGATTGGAGTTCTGAAGACTGCGAAGAAGGTTCGTTGAAAATCAAAGAAGAAATCCTAGATCCTGGCAACCATTTTTTGGCCGGCACTTCAAATTTGGCTCAAAACAAGATGAGTCCTTGTGAAGGACTGAACAGCTCAGACTGCGCCGATGATCTTGCTGGCGAGAAGAGCTGCGACAGCAGATCGACCGACTTGGATGCTCGAGATTGTCTCCAGGTTGAGATGCTCGATGAAACTTACCAATGCGGTCTTTGCTGGAGGAAGTTCGCTTATCCAGGCAAACTTAAATTACATTTACGGACTCTTCACGCAGGTTGCAAAATATGCGGGAAGATGTTCACAACTTCGAGCAACAAGAAAAGGCATATGAAGACGCATACGGGTGAAAAGTCGTACAGATGCGACATCTGCGGGAAAACGTTTACGCAGGATACGGGTCGCCAGAAGCACATGACGGTCCATACAGGAGAGAAGCCGTTCGCATGCGCAATTTGCCACAAGACGTTCGCAAGAGCCGAATCTTTAAGGAGACACACGCTAGCTCATGCGCAGGAGAAGCCGTACGTGTGCGAAATTTGCCAGAAGACGTTCGCGCAATCGGAGATGCTGAGCAGACACAGAAAGACGCATAAGACAAAGGAGCCTTCCCGATGTGAAATCTGCTTCAAGCAATTCTCAGAAAAGCAATGCTTGAGCCGACATATGATTCTGCACAGCGGCAAGATGCCGTTTGAATGCGCGTTATGCAATAAGAAGTTCAGCCGTCGCGACAATTATAATGTCCATATGAGAAAACATCATTGA
Protein Sequence: MEADWSSEDCEEGSLKIKEEILDPGNHFLAGTSNLAQNKMSPCEGLNSSDCADDLAGEKSCDSRSTDLDARDCLQVEMLDETYQCGLCWRKFAYPGKLKLHLRTLHAGCKICGKMFTTSSNKKRHMKTHTGEKSYRCDICGKTFTQDTGRQKHMTVHTGEKPFACAICHKTFARAESLRRHTLAHAQEKPYVCEICQKTFAQSEMLSRHRKTHKTKEPSRCEICFKQFSEKQCLSRHMILHSGKMPFECALCNKKFSRRDNYNVHMRKHH

Sequence clustering based on sequence similarity using MMseqs2