Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1 4.1e+02 1.2 0.4 23 45 5 27 2 34 0.83

2 7 0.14 57 4.0 0.1 21 52 31 62 26 63 0.85

3 7 0.16 62 3.8 0.2 20 44 58 82 46 89 0.70

4 7 0.13 52 4.1 0.0 23 46 88 111 79 117 0.80

5 7 0.028 11 6.3 0.0 21 51 114 144 110 145 0.87

6 7 0.00029 0.11 12.6 0.0 21 52 142 173 139 175 0.89

7 7 2.6 1e+03 -0.0 0.0 22 43 171 192 168 199 0.70

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1	4.1e+02	1.2	0.4	23	45	5	27	2	34	0.83
2	7	0.14	57	4.0	0.1	21	52	31	62	26	63	0.85
3	7	0.16	62	3.8	0.2	20	44	58	82	46	89	0.70
4	7	0.13	52	4.1	0.0	23	46	88	111	79	117	0.80
5	7	0.028	11	6.3	0.0	21	51	114	144	110	145	0.87
6	7	0.00029	0.11	12.6	0.0	21	52	142	173	139	175	0.89
7	7	2.6	1e+03	-0.0	0.0	22	43	171	192	168	199	0.70

Coding Sequence: ATGGAACGTGAAAAGCGTCACAAATGTACGGTGTGCGAAAAGTGTTTCACAAGGAGCCACCACCTCAAAACTCACATGCAAAGCCATACAGGGGAGAGGCCTTACAAATGTGAGGTCTGTAAGGGCACCTTTTCCCGCCCGACTACGTTAAAGAGCCATTTAAGAATCCACACTGGAGAAAAGCCTTACAAATGTACGATTTGTAAGGCCGAGCATGGAGACCTAGGGCGGTTAAAAGTCCATTTGCAGAGCCATACTGGGAAAAAATACGTCTGTGAGGTTTGCTCTGCGAAATTTTCATATTCGAACAGTTTGAAAACTCATTTAAGAACCCATACGGGAGAGAAGCCGTTCAAATGCGATTTCTGCGACGCCAAGTTCTCCGATGCGGGCAATCGGAAGAAGCATTTGAAGATCCATACCGGAGAGAAGCCTTTTCGTTGCGATTTCTGCGAGGCGAAGTTCACCGAATCGAATAATTTGAAGCAGCATTTGAAAATCCATACTGGCGAGAAGCCATTCAGTTGTGACGTTTGCGACGAGAAGTTCACCTGGAAACCGACTTTGAAGTCGCACATGAAGATCCACAAAGGAGCGGACAGTATGGACGTCTAG
Protein Sequence: MEREKRHKCTVCEKCFTRSHHLKTHMQSHTGERPYKCEVCKGTFSRPTTLKSHLRIHTGEKPYKCTICKAEHGDLGRLKVHLQSHTGKKYVCEVCSAKFSYSNSLKTHLRTHTGEKPFKCDFCDAKFSDAGNRKKHLKIHTGEKPFRCDFCEAKFTESNNLKQHLKIHTGEKPFSCDVCDEKFTWKPTLKSHMKIHKGADSMDV

Sequence clustering based on sequence similarity using MMseqs2