Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.44 1.7e+02 2.4 0.0 26 46 64 84 55 91 0.84

2 8 0.5 2e+02 2.2 0.1 21 44 87 110 83 114 0.83

3 8 0.00061 0.24 11.6 0.0 20 51 114 145 107 148 0.83

4 8 0.0019 0.75 10.0 0.0 21 52 171 202 162 204 0.87

5 8 1.6 6.3e+02 0.6 0.1 21 35 199 213 197 230 0.72

6 8 3.5 1.4e+03 -0.5 0.0 21 44 227 250 214 256 0.76

7 8 0.012 4.7 7.4 0.0 21 48 256 283 251 287 0.86

8 8 0.021 8.5 6.6 0.2 21 48 284 311 282 315 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.44	1.7e+02	2.4	0.0	26	46	64	84	55	91	0.84
2	8	0.5	2e+02	2.2	0.1	21	44	87	110	83	114	0.83
3	8	0.00061	0.24	11.6	0.0	20	51	114	145	107	148	0.83
4	8	0.0019	0.75	10.0	0.0	21	52	171	202	162	204	0.87
5	8	1.6	6.3e+02	0.6	0.1	21	35	199	213	197	230	0.72
6	8	3.5	1.4e+03	-0.5	0.0	21	44	227	250	214	256	0.76
7	8	0.012	4.7	7.4	0.0	21	48	256	283	251	287	0.86
8	8	0.021	8.5	6.6	0.2	21	48	284	311	282	315	0.92

Coding Sequence: ATGGAGGAAGATATTAGAAAAGAAAATGAGGATGTACCTGAAGAAGCTGTCATTATTAAAGAAGAGCCCTTTGGATCGAAAGGGCATTTTATTGTTGGGGATGATGGAATGGAAGAAATTATGATGGACGATGAGGAAGAGGACTGTCAAAATTTCAACTTGGAAAAACCTTCAAAAAATCTTGGGTACAGTTGCATGGTCTGCGAAAAGAAGTTTTCTCAGGCTAGTAATTTGAAGACGCATATGAGGACTCATACAGGGGAGAAGCCTTACAGTTGTAAGGTCTGCTGGAAGTACTTCACTACAGCAAGTAGCGTCAGAATTCATATGAGATCTCATACTGGAGAGCAACCATTTAGCTGTGATGTGTGCAAAAAGAAGTTTACCAAAAACAACAATCTTATCAGACATATGAAAGTCCATTCTGGACTAAAGCCTTTCAGCTGTGAAGTCTGCGAGAGGAAGTTTTCCGAAAAAGGTGTCTTGGAAAGCCACATGAGAACCCATACTGGCGAGAAACCCTATAACTGTGATGTATGCCACAAAACGTTTGCTCAAGCCATCAATATGAAAAATCATATGAAAATCCATACAGGCGAGAAGCCCCATATGTGTGAAATTTGCAACAAAAAGTTTGTCGAAAAAGGCGCTTTGAATAATCATATGAGAACCCATACTGGGGAGAAGCCGCACAGCTGTGAGTTTTGTGACAAAAGGTTTACGACGGCGAATACCATGAGGATTCATGTTATGAGAATCCATACTGGAGAGAAGCCTTATACTTGTGAAGTTTGTCAGAAGAAGTTTACTGAAGATAAAGCTCTGAGAGCCCATGTTAGGATACACACTGGGGAAAAGCCTTTCAGCTGTGAGGTCTGCTCCAAGGAATACCCTACAGCACATAGCATGAGGAGACATATGACGTTAATTCATACTGGATATGCCTACCAATATTTATGA
Protein Sequence: MEEDIRKENEDVPEEAVIIKEEPFGSKGHFIVGDDGMEEIMMDDEEEDCQNFNLEKPSKNLGYSCMVCEKKFSQASNLKTHMRTHTGEKPYSCKVCWKYFTTASSVRIHMRSHTGEQPFSCDVCKKKFTKNNNLIRHMKVHSGLKPFSCEVCERKFSEKGVLESHMRTHTGEKPYNCDVCHKTFAQAINMKNHMKIHTGEKPHMCEICNKKFVEKGALNNHMRTHTGEKPHSCEFCDKRFTTANTMRIHVMRIHTGEKPYTCEVCQKKFTEDKALRAHVRIHTGEKPFSCEVCSKEYPTAHSMRRHMTLIHTGYAYQYL

Sequence clustering based on sequence similarity using MMseqs2