Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.19 75 3.6 0.0 26 51 10 35 2 37 0.83

2 8 1.4 5.4e+02 0.8 0.0 21 34 33 46 29 60 0.76

3 8 0.0033 1.3 9.2 0.0 21 43 61 83 57 92 0.90

4 8 0.74 2.9e+02 1.7 0.0 22 44 90 112 87 119 0.85

5 8 0.86 3.4e+02 1.5 0.0 22 52 118 148 113 150 0.83

6 8 0.33 1.3e+02 2.8 0.1 23 44 147 168 137 172 0.84

7 8 0.0013 0.52 10.5 0.0 21 44 173 196 169 200 0.91

8 8 0.0023 0.89 9.7 0.1 21 48 201 228 197 232 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.19	75	3.6	0.0	26	51	10	35	2	37	0.83
2	8	1.4	5.4e+02	0.8	0.0	21	34	33	46	29	60	0.76
3	8	0.0033	1.3	9.2	0.0	21	43	61	83	57	92	0.90
4	8	0.74	2.9e+02	1.7	0.0	22	44	90	112	87	119	0.85
5	8	0.86	3.4e+02	1.5	0.0	22	52	118	148	113	150	0.83
6	8	0.33	1.3e+02	2.8	0.1	23	44	147	168	137	172	0.84
7	8	0.0013	0.52	10.5	0.0	21	44	173	196	169	200	0.91
8	8	0.0023	0.89	9.7	0.1	21	48	201	228	197	232	0.92

Coding Sequence: ATGAAGTCCCACACAGGAGAAAGGTTTTTATGTGATTTCTGCGATGCCCTATTCACCACAGCACAAGGTTTGAAGAGGCATGTTACTATTCACAGTGGAGAGAAGCCGTTTAAATGTGATATCTGCGACACCACATACGATCGGTGGGCAAGTTTGAAACTACACGTTATGACTCATACAGGAGAGAAGCCTTTTATATGTGATATCTGCGATGCCGCATTCACTTCTTCAAAATTTTTGGAAAGACACAGTATTGTCCACAGAGGAGAGAAGTCGTTCAAATGTAGTAGGTGTGACGCCGCATTCCCCAAGATTGGAGATTTGAGACGACACGTTGTGACCCATACAGGAGAGAAGTCGTTTAAATGTGATACATGCAATGCCAGATTTACCCAGCCGATAAGTTTAAAAAATCATATGAGATACCACACTCAAGGGAAGCCGTTTAAGTGTGATATCTGCGATGCCAGATTTCCCAGGTCGAACATTTTAAAGGATCATGTTATGACCCACACTGGGGAGAAGCCGTTTAAATGTGACATCTGCAATGCTGCATTCATCCAGTTGGGAAATTTAAAACAACACATGATGACCCACACAGGGGAGAAGCCGTTAAAATGTGAAATCTGCAATGCCAAATTCTCTGCGACGGCAACTTTGAATCGACACATTAGGATCACACATACAGGAGAGAAGTCTCAAAAATCATTAAACAACAAATGA
Protein Sequence: MKSHTGERFLCDFCDALFTTAQGLKRHVTIHSGEKPFKCDICDTTYDRWASLKLHVMTHTGEKPFICDICDAAFTSSKFLERHSIVHRGEKSFKCSRCDAAFPKIGDLRRHVVTHTGEKSFKCDTCNARFTQPISLKNHMRYHTQGKPFKCDICDARFPRSNILKDHVMTHTGEKPFKCDICNAAFIQLGNLKQHMMTHTGEKPLKCEICNAKFSATATLNRHIRITHTGEKSQKSLNNK

Sequence clustering based on sequence similarity using MMseqs2