Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.58 2.3e+02 2.0 0.1 23 44 12 33 9 37 0.87

2 11 0.031 12 6.1 0.0 21 48 38 65 34 69 0.85

3 11 0.002 0.78 9.9 0.0 21 48 66 93 63 99 0.87

4 11 0.57 2.2e+02 2.1 0.0 23 45 96 118 93 121 0.89

5 11 0.002 0.79 9.9 0.1 21 46 122 147 118 153 0.87

6 11 0.15 61 3.9 0.0 21 51 150 180 146 182 0.85

7 11 0.077 30 4.8 0.0 21 45 178 202 175 205 0.91

8 11 0.011 4.5 7.5 0.0 21 45 206 230 202 233 0.91

9 11 0.047 19 5.5 0.1 21 45 234 258 230 265 0.85

10 11 0.012 4.8 7.4 0.1 20 52 261 293 254 294 0.83

11 11 0.028 11 6.2 0.0 21 45 290 314 288 319 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.58	2.3e+02	2.0	0.1	23	44	12	33	9	37	0.87
2	11	0.031	12	6.1	0.0	21	48	38	65	34	69	0.85
3	11	0.002	0.78	9.9	0.0	21	48	66	93	63	99	0.87
4	11	0.57	2.2e+02	2.1	0.0	23	45	96	118	93	121	0.89
5	11	0.002	0.79	9.9	0.1	21	46	122	147	118	153	0.87
6	11	0.15	61	3.9	0.0	21	51	150	180	146	182	0.85
7	11	0.077	30	4.8	0.0	21	45	178	202	175	205	0.91
8	11	0.011	4.5	7.5	0.0	21	45	206	230	202	233	0.91
9	11	0.047	19	5.5	0.1	21	45	234	258	230	265	0.85
10	11	0.012	4.8	7.4	0.1	20	52	261	293	254	294	0.83
11	11	0.028	11	6.2	0.0	21	45	290	314	288	319	0.89

Coding Sequence: ATGAGGAGGCATATGATAATTCATACTGGAGTAAAGCCTTACAAATGTGAATATTGTGATGCCAAGTTTGTTCAGCAAAGCAGTATTAAAAGGCATATGAGAACTCATACTGGAGAGAAGCCATACAAATGTGAAATTTGTCAGGCAGATTTTTCCGATTTACACAGTGTGAAGAGGCATTTTTTACTCCATACTGGAGAAAAGCCTTTCAGTTGCGATCTCTGCGAAGCCAAATTTGCTCAATCATACCAGTTGAAGGCGCACTTGATAATACACACAGGACTAAAGCCTCATAAATGCGAGCTTTGTGAAGCGAATTTTACAGAGTCAAGCTCTTTGAAAGTCCATATGAGAATTCACACTGGAGAGAAGCCTTACTGTTGTGATCAATGTGATGCTAAGTTTTCTCAATCGAGCAATCTGAAGGCGCATATGAGGACCCACACGGGAGAGAAGCCTTTCAAATGTGAGCTTTGTGATGCTAAGTTTTCCGAGATGAGCTCTATGAAGAAACATTTGAGAGTTCATACTGGAGAGAAGCCTTTCAAATGTGAGCTTTGTGATGCAAAGTTTGCCCGGTCGAGCCATTTGAAAGTTCATTTAAGAACGCATACTGGAGAGAAGCCCTTCAAATGTGAGCTTTGTGATGCCAGGTTTACGGATTCGAGCACAATGAAAAGGCATTTAAGAAGTCATACGGGGGAAAAGCCATACAAATGTGAGCTTTGTGACTCAAGGTTTTCTCAACCGCGCAGTTTGAAGGTGCATATGAGATCTCATACCGGAGAGAAACCGTACAAATGTGAACATTGTGTGGCCAAATACTCCGATCCCAGTTCGTTGAGGAAGCATTTGAAAATTCATTCCGGAGAAAAGCCGTACAAATGTGAGCTTTGTGAGGCCAAGTTCTCAGAAGGGAGCAATCTAAAGAAGCATATTATGAGAATTCACTCCAGTGCCTTGATTCCCACTTGA
Protein Sequence: MRRHMIIHTGVKPYKCEYCDAKFVQQSSIKRHMRTHTGEKPYKCEICQADFSDLHSVKRHFLLHTGEKPFSCDLCEAKFAQSYQLKAHLIIHTGLKPHKCELCEANFTESSSLKVHMRIHTGEKPYCCDQCDAKFSQSSNLKAHMRTHTGEKPFKCELCDAKFSEMSSMKKHLRVHTGEKPFKCELCDAKFARSSHLKVHLRTHTGEKPFKCELCDARFTDSSTMKRHLRSHTGEKPYKCELCDSRFSQPRSLKVHMRSHTGEKPYKCEHCVAKYSDPSSLRKHLKIHSGEKPYKCELCEAKFSEGSNLKKHIMRIHSSALIPT

Sequence clustering based on sequence similarity using MMseqs2