Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.044 18 5.6 0.2 19 45 63 88 56 91 0.85

2 6 0.00019 0.076 13.2 0.1 4 46 78 117 75 120 0.78

3 6 0.00014 0.056 13.6 0.1 21 45 120 144 116 148 0.91

4 6 0.046 18 5.6 0.0 22 45 149 172 146 179 0.87

5 6 0.0032 1.3 9.2 0.0 26 47 181 202 174 207 0.85

6 6 3.6e-05 0.014 15.5 0.0 21 50 204 233 201 235 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.044	18	5.6	0.2	19	45	63	88	56	91	0.85
2	6	0.00019	0.076	13.2	0.1	4	46	78	117	75	120	0.78
3	6	0.00014	0.056	13.6	0.1	21	45	120	144	116	148	0.91
4	6	0.046	18	5.6	0.0	22	45	149	172	146	179	0.87
5	6	0.0032	1.3	9.2	0.0	26	47	181	202	174	207	0.85
6	6	3.6e-05	0.014	15.5	0.0	21	50	204	233	201	235	0.92

Coding Sequence: ATGGAAGAAGAAATTTTAAAAATAAAAGAAGAACGGATCGACGATTTTGGAACCCATGTCTTTATCAAAGAAGAAATTATAGACGATGTTGAAGAGGGAAATTTTGAAGAATTGTGGGAGAATAGTGAAATTGAGGAGGATGAAGTTCTTGGGGAGCTTGAAGGTTCTTCAGGCATAGAAACGAAGAGTCAAGAAAGGCCGTTCACATGTTTGGTTTGCGATGAAAAGTTCAAGAGGGCTCATCATTTGAAAACGCATGTACAAAGGCATACCGGAGAAAGGAGTCACACTTGTCCTTTCTGCCAAGCCAAGTTCATCGTGTCCACCAATTTTAAGAATCACTTGAGGATCCATACTGGAGAGAAGCCGTTCTGCTGTTCGGTTTGCGGTTCCAAATTTATCCAGTCGAGCAATCTGAAAAGGCACATGAAAACCCATACTGGAGAAAAGGTGCACTCCTGTGACTTCTGTGATGCAAAGTTCGCCTCCGCGAGCAATTTGAAAAGACACGTAAACACCCATACTGAAGTAAAGGAGCACAAATGTGAATTTTGCGAAGCGAAGTTTATTCAGGCGAGCAATTTGAAAAGACATCTTAAAACCCATACTGGAGAGAAGCCGTTCGTTTGTGAGTTCTGCGGAGCCAAGTTCATCCAGTCGACCAATATGAAGAGACACGTCGCCAAAGTCCATTTTGATAGAAAAATTCCGTTCAGCTGA
Protein Sequence: MEEEILKIKEERIDDFGTHVFIKEEIIDDVEEGNFEELWENSEIEEDEVLGELEGSSGIETKSQERPFTCLVCDEKFKRAHHLKTHVQRHTGERSHTCPFCQAKFIVSTNFKNHLRIHTGEKPFCCSVCGSKFIQSSNLKRHMKTHTGEKVHSCDFCDAKFASASNLKRHVNTHTEVKEHKCEFCEAKFIQASNLKRHLKTHTGEKPFVCEFCGAKFIQSTNMKRHVAKVHFDRKIPFS

Sequence clustering based on sequence similarity using MMseqs2