Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.062 24 5.1 0.0 21 44 44 67 38 71 0.88

2 8 0.0079 3.1 8.0 0.0 21 43 72 94 68 99 0.90

3 8 0.0054 2.1 8.5 0.0 21 43 100 122 95 127 0.89

4 8 0.0065 2.6 8.3 0.0 21 43 128 150 123 159 0.86

5 8 0.0012 0.49 10.6 0.0 21 43 156 178 151 183 0.90

6 8 0.0049 1.9 8.7 0.0 21 43 184 206 179 215 0.88

7 8 0.24 95 3.2 0.0 21 43 212 234 208 238 0.85

8 8 0.0011 0.45 10.7 0.0 20 44 239 263 228 271 0.81

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.062	24	5.1	21	44	44	67	38	71	0.88
2	8	0.0079	3.1	8.0	21	43	72	94	68	99	0.90
3	8	0.0054	2.1	8.5	21	43	100	122	95	127	0.89
4	8	0.0065	2.6	8.3	21	43	128	150	123	159	0.86
5	8	0.0012	0.49	10.6	21	43	156	178	151	183	0.90
6	8	0.0049	1.9	8.7	21	43	184	206	179	215	0.88
7	8	0.24	95	3.2	21	43	212	234	208	238	0.85
8	8	0.0011	0.45	10.7	20	44	239	263	228	271	0.81

Coding Sequence: ATGCTCGATCACAAGGATGTAGTTTTGAGTGTTTATGGTGACTTGAGACTTTCAATTTGCTACCTTGATATATGCGATGCTACATTCAGCGCATCTGGTGATTTGACAAGGCTTAATAGGATCCACACAGGAGAGAAGCCATATAAATGTGATATCTGCGACGCTACATTTACCATCTTAAACAGTTTGAAAAGGCATAATAGGATCCACACAGGGGAGAAGCCATTTAAATGTGATATCTGCGATGCAACGTTCACGCAGTCAGGCCATTTGAAAATTCATAATAGGACCCACACAGGAGAGAAGCCATTTAAATGTGATATCTGCGATGCAACGTTCACGCAGTCAGGCCAGTTGAAACTTCATAATAGGACCCACACAGGAGAGAAGCCATTTAAATGTTATATCTGCGATGCAACGTTCACGCAGTCAGGCCAGTTGAAAATTCATAATAGGACCCACACAGGAGAGAAGCCATATAAATGTGGTATCTGCGATGCTACATTTTCTAACTCAGGCAATTTGAAAAAGCATAATAGGACCCACACAGGAGAGAAGCCATATAAATGTGACTTCTGCGAAGCTGCATTCACCGCGTCATGGGAGTTGAGAAGGCATAATGTGACCCACACAGGAGAGAAGCCATATAAATGTGATATCTGCGATGCTACATTCATCGGCTCAGGGGCATTAAAAGTGCATAATAGGACCCACACTGGAGAGAAGCCATTTAAATGTGACATCTGCGACGCAACGTTCTCGCAGTCAAGCCATTTAAAAACGCATAAAAGGACACACACCGGAGAGAAGCCATATAAATTACATCGACTATACCTTCCGGCTTCTGATGGAGAAGAAAATGAATATCCTCATCCAAGTTCCGAATGCGAAGATAAAGTCCTTCATACTGTACACACAGTTAGAGCGATCTCGACAAACGTTTGCAAAAGCATTTACAGATCTTTGAGTCAACACTACTCCAAAGAAGAGCTGCAAGTCCTTTCTCAACAAGCTCATCAAACCTAG
Protein Sequence: MLDHKDVVLSVYGDLRLSICYLDICDATFSASGDLTRLNRIHTGEKPYKCDICDATFTILNSLKRHNRIHTGEKPFKCDICDATFTQSGHLKIHNRTHTGEKPFKCDICDATFTQSGQLKLHNRTHTGEKPFKCYICDATFTQSGQLKIHNRTHTGEKPYKCGICDATFSNSGNLKKHNRTHTGEKPYKCDFCEAAFTASWELRRHNVTHTGEKPYKCDICDATFIGSGALKVHNRTHTGEKPFKCDICDATFSQSSHLKTHKRTHTGEKPYKLHRLYLPASDGEENEYPHPSSECEDKVLHTVHTVRAISTNVCKSIYRSLSQHYSKEELQVLSQQAHQT

Sequence clustering based on sequence similarity using MMseqs2