Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.9e-17 3.5e-13 51.9 0.1 33 83 9 56 6 62 0.90

2 3 3.6 2.1e+04 -1.9 0.0 26 38 65 77 56 88 0.60

3 3 6.6 3.9e+04 -2.8 0.0 28 42 172 186 167 187 0.71

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.9e-17	3.5e-13	51.9	0.1	33	83	9	56	6	62	0.90
2	3	3.6	2.1e+04	-1.9	0.0	26	38	65	77	56	88	0.60
3	3	6.6	3.9e+04	-2.8	0.0	28	42	172	186	167	187	0.71

Coding Sequence: ATGATGGGAAGAAAGATTAATTGTAGTGATCACTTTCCATTTTACAAACAAAACGACGATCGGTGGAAGAACTCTGTTAGGCATAATTTATCAATAAACCCACATTTTAGAAAGGGAGGAAAAGCAGTTCAGGGAGCTGGACACCTTTGGACTATTGCTCAACGAGATCCCAGAAAATGCTCTCAAATTaaACAAAGAATAACCCAGTTCTTCCAGAATTCGTACACGGAATCAACTCGTACACAACAAGAATTGGTGGAGCAAGAATTGCAGGCTGCTACGGAGAGCATCTTAGGTGAAATTAACAACACTTATACCATTGATACTTCGAGAAATGATAACATAGAAGTTGAATATATACATATCGGTGATACAACCGCTGGGTTAGAAGATTTTTTAGCACCTCCAGTTTCGAAACAAGACATTGTCAACGAATGTGGTCTTGGAAATGACATTTTCATCACCGACATAAACCCGAATGTGTTGGGATTAAATCTAGCTGAAGTTGAAGGGATGGCTGATAACTATGAAGACGTTTTTGAATATTATACAACAAAACAATGA
Protein Sequence: MMGRKINCSDHFPFYKQNDDRWKNSVRHNLSINPHFRKGGKAVQGAGHLWTIAQRDPRKCSQIKQRITQFFQNSYTESTRTQQELVEQELQAATESILGEINNTYTIDTSRNDNIEVEYIHIGDTTAGLEDFLAPPVSKQDIVNECGLGNDIFITDINPNVLGLNLAEVEGMADNYEDVFEYYTTKQ

Sequence clustering based on sequence similarity using MMseqs2