Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_943138245.1
Location
CALPBP010001253.1:489341-497361[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.8e-17 1.3e-13 52.0 0.0 6 69 431 492 426 500 0.89
2 2 0.82 5.9e+03 -1.4 0.0 42 61 1083 1102 1082 1112 0.87

Sequence Information

Coding Sequence
atgggTCGTAAGTGTAATGTATTAGATTGTCCATCAGATTCAAATCGAACCGAAGACAATGGCGTAACATTTCATAAAATGCCATTTCATCCAGATTTACGACCAAAATGGATAGAATTATGTCGCATTCCCAAAGAAAGGCAAACAAATAAAGTGATTTATGTTTGTTCAAGACATTTTAGACGAACAGATTTCTGCAATTTCAAAGGTACAAAGTATATGCTTCGGCAGGGTGCTCTGCCCTCAGTATTTCCGTGGACTAAAAGCATTATAATACCACCACAAACTAGTAAAACTACATTACCAATAGATGAAGAAAGTAATTCTATAGAAATTAAAACCGAAGAACCTGAAGAAGAAAAGTCAAATAATGTTGATGAATTAGGTGAAGTAGAAATCAAAATAGAAATTCCTGAAGAAcctgaagaagaaaaagaaaaacctaaaataaaaaaagatatttctCCCCCAGCGAAAAAAGAcacaacaactacaagtaaaaAAGAACCTGTTCCAgttgttataaataaagaaattactgAAATAATACCAATTCCaccaatagaaaataatatatctcCTGTTACAAGAACCGAACCTATAAATTTCTTGCCAGGGACCAGAATAGAAGCtaatgattttaatgaaaagtgGAATCCTGCAACTATTTTAGAAGTAGATTATGATGAAAATGAAGTATTTGTTGAATtcgaaaaacatttaaataaagcaAACGAGTGGATACCAATGGATAGTTCCAGATTACGACCATATCATCCGCCGTCCAATAATATTGAAACATATGCTGTAGGAGAAAGAGTTCTTGCAGCTTGGATAAAAACAGTTAATAAATTTCCAGCTACAATTAAAAAAGTCATAGATTCCGAAACATATGAAGTCTTATTTGATGATGGCTTTTTAAAAGTACTGAAATATTCCAAACTTGCAAAAATTAAAGACGTATCAGCTAATCGGGGTCGTCTGAAAAAACATTCATCGCCTTTATTCGATCCTGTAGTTGGATCGAAAGAAGACAGGAGAGAAAGAAAACGAAAATTAAACGTTGCAGAATTGTTTGGCAAAATTCCTGCtggcaataaaaaatataaaggagACGAATATGTTAGATCTGAACCAGAAGATGATGTACAATCTCAAGAAGAATTTAGAAGTACTGGTTCATCTAGTCAAAATGAAGGTGAAGAATGGACTTGTCGCTGGTTAAACGGTGAACCAGTTGGAATTGAATCAGAACTAGAAGGACTTGATGGTCCAAGACGATCAATTATAGTCGCAGATCATCGTTTGCCTCCAGGTTGGGAAAAACATTTAACTCAGAGGCTACATGGAAATAACGCCGGAAAATGGGACGCATTTATAATAAGTCCTAATGGGAAAAGATTTTCAACTCGCGCACAAGTAAAAACATGGTTGGAAGATAATAAAATGGATTATAACGTAGAAAGATTCGATTTTTGCCTGCATTTAAATCGGGCCAAAAAATTAGGTCTATATGAAATTACCGACCCTGACGCGTTATCTGCAGCAAAAGCTGCTCATCCCAAAGAACCATTCAAATCTCACAAACGATCAAAATCCCACAGTACGAAAATTTCAACTCCAAAAAGTGGTAGTACTGTCAATTTACCCGTAACTCCAGATATCCACGAGCGTTTTcctgaagaagaagaaatagacACTTCACATTACTTGAAAATTATTCATGAAGATGGTAGTTACAAGTGCCCAATAGAAGGCTGTGGAAAAATTTTCCGAAAAGAAAATCTAGCACAGATGCACGTTAAACATTACCATCCAGAATCTGCCAAACTTTTAGGATCCACTCCAAATGTTGCTGATTTAGCGTACGCTAGAACTGTTGGAGAACATATTGACGACATTGTACCAAAAGCAAGAGGTGTAGGCTCTCCTCacgaaaaacaagaaaaaagtgTTAGGTCTGAATCAACTCCAAGACCAAAATCTACCCTAAGAATTTTGCAACCTAAACTCCAATCAAAAATAGAGGAAGGAGAAATGAGAAAATCCATCATATCCCCTCCTCTTCATCTTCCAAAACAAGCCAAAGATTCAGAAATTATCAGATTGCTGAACAGCGAACCAAAAACCAAAACAATTGAATCTATTTACGAAACTGTTTCTTCAAAAGCTCACGAACCTGTTCCAATAAAAGAAGAACCTGTTGAAAAATACCCAGACATCAAACTTAAAGATCTATTGCACAAAGCAGAACCAATTCCCCTGTTTAAAAAAGAAGAACACAGACCAACCGGAATCAAAACTCTTCTTCCTGTAATACGTCACAATCTAGACGAAATTAAACAAGAGATGGAGGAACCGGAACCTGGTTTTCACGCACTTCCAAAAGCGGTTGAAAGGTTAAAACCAAGAAAGCGACAATCTTCAGACAACAGCGAAGCAAAGAAAAGAAGATCTTTTAGATATGAGGACGAATTGTCGGATTTCTATGAAGCGGATAGTCATTCGCAAGATTCCTTCAAAGAGAAGAATGTTTTTGAAATGCAGCCTATTGCTCCAGTGGCAGAATCGCCGCAAGTTATTATCGAGGGGGGCGAAGTTATTCGTTTAGTACATATGAGGAGtgaagaaataataaattgtacatgTGGTATAACAGAAGAAGACGGTCTTATGATTCAATGTGAGTTATGTTTATGTTGGCAACACGctcattgtaataatattaaaaaagaaaacgaAGTAcccgaaaaatatatttgttatatatgtaaaaatcctCCAAGAATGcgtgtttctaaaaaatatatacatgacCAAGATTGGTTAAAACAAGGAGTGCTCCCAGCCGCAAATTATCATACGAAAGATGAAGAAGCTCTCAAagagaaatttgaaaaattacgaAAATCACATGAACTTAGTGGATGTTTAGtggaattaaatgaatatataaaCAATCTTCGAATTAAACTTAATATTGCAGAtaaCAAAGATCACcctaaactttatttatggagtAAAGCGTGGAACAAGCCAGTCCCTAATGAAAACTTAAACGCGatgttaaattcaaaaacaGATCATATTAAAGATATTAAAGACGAAAATCTGAATTCAAGCTTTTCTGGTTCGGATCATAGTTATATAAAAAGCAGCACATTCGGCGATATTGCCCTTAAAAGCATGTTAGAACCACCAGTTGAAGAAATAAAGCACGAAAATAAACATATGCTCGACACTGACAAAATTAAATCAGAATCAGAACTAATTTCTATTCTTGAAGAAGGGACAAATATTAAATCTGCCATAAAAACAGAACCGCCAGAATTCCCAAAAATTGATCTGAATACAATGATCGCTAATAATTTGGGTGATAAACCCGAATCAAAAAATGATCTTCCAGAagttaataaagaaaatgcCTTGAGCGGAATTTTGAGCACCGGTTCTTTAGAGTTGGCGTTATCCCAAACTGATTTAGTTACTTCATTCGCCCACTTAAATGAAGTTGAAACAACTCCCATAGTGCCCCCTGTCAATATTCCCCAACCCGAAGCAGTTATAGATCCATCCGATTGTCGAATGAATTTAATTGAACATGTTTCTCATTTCCAAAGTCTGGTGGACGAAAGATTGAATTGCATTGAAGCGGAAATAAGTGaattggAGGACCAAGATTCAGATGATGATGAGGACGCATATCCAAAAATGAAACAGTCGTTACAAATGTTGATAAAAGATCTTGCAGCAATGCGGCAGATAGCTGCTTTgagcaattaa
Protein Sequence
MGRKCNVLDCPSDSNRTEDNGVTFHKMPFHPDLRPKWIELCRIPKERQTNKVIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKSIIIPPQTSKTTLPIDEESNSIEIKTEEPEEEKSNNVDELGEVEIKIEIPEEPEEEKEKPKIKKDISPPAKKDTTTTSKKEPVPVVINKEITEIIPIPPIENNISPVTRTEPINFLPGTRIEANDFNEKWNPATILEVDYDENEVFVEFEKHLNKANEWIPMDSSRLRPYHPPSNNIETYAVGERVLAAWIKTVNKFPATIKKVIDSETYEVLFDDGFLKVLKYSKLAKIKDVSANRGRLKKHSSPLFDPVVGSKEDRRERKRKLNVAELFGKIPAGNKKYKGDEYVRSEPEDDVQSQEEFRSTGSSSQNEGEEWTCRWLNGEPVGIESELEGLDGPRRSIIVADHRLPPGWEKHLTQRLHGNNAGKWDAFIISPNGKRFSTRAQVKTWLEDNKMDYNVERFDFCLHLNRAKKLGLYEITDPDALSAAKAAHPKEPFKSHKRSKSHSTKISTPKSGSTVNLPVTPDIHERFPEEEEIDTSHYLKIIHEDGSYKCPIEGCGKIFRKENLAQMHVKHYHPESAKLLGSTPNVADLAYARTVGEHIDDIVPKARGVGSPHEKQEKSVRSESTPRPKSTLRILQPKLQSKIEEGEMRKSIISPPLHLPKQAKDSEIIRLLNSEPKTKTIESIYETVSSKAHEPVPIKEEPVEKYPDIKLKDLLHKAEPIPLFKKEEHRPTGIKTLLPVIRHNLDEIKQEMEEPEPGFHALPKAVERLKPRKRQSSDNSEAKKRRSFRYEDELSDFYEADSHSQDSFKEKNVFEMQPIAPVAESPQVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIKKENEVPEKYICYICKNPPRMRVSKKYIHDQDWLKQGVLPAANYHTKDEEALKEKFEKLRKSHELSGCLVELNEYINNLRIKLNIADNKDHPKLYLWSKAWNKPVPNENLNAMLNSKTDHIKDIKDENLNSSFSGSDHSYIKSSTFGDIALKSMLEPPVEEIKHENKHMLDTDKIKSESELISILEEGTNIKSAIKTEPPEFPKIDLNTMIANNLGDKPESKNDLPEVNKENALSGILSTGSLELALSQTDLVTSFAHLNEVETTPIVPPVNIPQPEAVIDPSDCRMNLIEHVSHFQSLVDERLNCIEAEISELEDQDSDDDEDAYPKMKQSLQMLIKDLAAMRQIAALSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00768532;
90% Identity
iTF_01104538;
80% Identity
iTF_01104538;