Basic Information

Gene Symbol
-
Assembly
GCA_951751655.1
Location
OX632360.1:3676785-3682743[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.00029 0.033 15.2 1.0 1 23 418 440 418 440 0.95
2 18 0.063 7.2 7.8 1.8 2 23 481 502 480 502 0.95
3 18 0.23 26 6.1 1.0 2 23 578 600 577 600 0.93
4 18 0.0018 0.21 12.6 1.2 1 23 604 626 604 626 0.97
5 18 8.8e-05 0.01 16.8 2.1 1 20 744 763 744 765 0.94
6 18 0.00013 0.015 16.3 0.8 1 20 774 793 774 798 0.93
7 18 0.00097 0.11 13.5 2.5 1 23 889 911 889 911 0.97
8 18 5.7e-05 0.0065 17.4 3.9 1 23 978 1000 978 1000 0.97
9 18 0.00061 0.071 14.1 1.1 1 20 1005 1024 1005 1026 0.94
10 18 0.012 1.4 10.0 0.2 2 23 1037 1058 1037 1058 0.95
11 18 1.5e-05 0.0017 19.2 0.7 2 23 1097 1118 1096 1118 0.97
12 18 3e-05 0.0034 18.3 1.6 1 23 1123 1145 1123 1145 0.95
13 18 9.6e-05 0.011 16.7 1.8 1 23 1151 1173 1151 1173 0.98
14 18 5.3e-06 0.0006 20.6 0.4 1 23 1189 1211 1189 1211 0.95
15 18 1.7e-06 0.00019 22.2 0.3 1 23 1217 1239 1217 1239 0.99
16 18 3.2e-05 0.0036 18.2 0.3 1 23 1245 1267 1245 1267 0.98
17 18 0.00017 0.02 15.9 4.1 1 23 1273 1295 1273 1295 0.96
18 18 0.012 1.4 10.1 0.4 1 20 1301 1320 1301 1322 0.89

Sequence Information

Coding Sequence
ATGGACGCGGTTGAGATGAATGTGGCGGAGGATTCGCCCGAGGAAGCGATCGAGGAAACGGTACCCGAGATCTGTCGGGTCTGTTTGCTCGGTCATATGATAACGCGCGATCTCTTCGTCGAAAACAATGCCGTTTCGCTTTCAACCAAAGCCATGAGCTTTGCCAGCGTTAAGATGGCGCCCGAGGATGGCTTGCCCGCCCGGGTTTGTTGCGACTGCGCGGACAAGCTGGAAGCCGCGTACGAGTTCAAACTCCAGGTGGAGCAGGCGGACAACGTTTTGCGCCAGAGGTACGACGGTCCGAACATCAAGGACGAGCTCTTCTTCAACGAGGTGGAGGTCCATCTAGAGGTGGAGCGAGGCGACGACGCGCACTCCCTCACCGTGGACGCTCGCTATCAGGCAACCGTAGACAGCTTGAACGCGGTTGTTCCGGTCGAGGCAAAGTCTACGCTGCTCAAGGATCACCTGGCGCTGTTGGAAGTGGCCAAACTCGCCAAGCAGCAGGGCGTCCTCGAAGTTCACGGCAATTTTGGCGCTGAAAAACGAATCCAGCGGCTGGCGAACGTCCGACGAGAAAACGAGCCGCGCACCGGCGAGCCGGAAGTGGGTTACGCTTTCGCCGGGCTAACGGGCAAAAATCTCACATACGCGACCTTCCTGGAAACACGCATTTTGCCACTCGAATCGTCACAGGACAAAGATGACGGTGTTTCGGACGAGGAGGAGAGCGGTGTGTCGGCGATGCTTCGAGCCAATGAGCAGCACTACCTGGACGAGACCGAGGGCGCCGTGGTCGAGTTGGACGACTGCGCCGAGGCGTATCGCGACTCGGCCAAATCCGAGGGCCTCCCAGACGGCATCACCGCCGAGGAGCACAATTACATAATGCAGCAAGGTTACGAGCTGACGCGCAACGGGGAGGATCTCGTGGGTGCGCAGGAGAGCGTCGACTCGGTAAACGAGTCCGACAATTATTTGTCTCTGATCGACGACGAGATGAACACCGCCAAGGAGACCGAAGTCGCGCAACCGGAAGTTGGAGAAATCAACGAGGAGGCACAGACGGAAGTTGGGCCGGTCGAGACGGACGTTACGACGGAAGAAACGTCGCCGGGCGAGACGCGACGGAGCAAACGAAAAGCGAACAAACGTCGACGTACCGTGAGCGAGGAGGACAACTACTTCGAGAATTTGAGTCTCAGCAGTAGATTGAAACAAGCGCAGCTCGAGAAGAACGAAAAATTTTACTTTCTCTGCTATCTGTGCGACAAAAGATTCGTTTCCAAGGATATACTGAAGGAGCACATGCGCTCGCACGCGGAAGTCAGGCGCGCACTGTCGTTGAGGAAGGCCGAGAGATCGGATCGTCGGGGTTCGACGAGCCCGACGAAGACGAGCAACGTCGAGAACTCGACGAGTTCCGGCAAGAAGGCCAACAAGTGTCCCCACTGCGGCAAAGAGTATCTCTACGTGATATCTTTCAACAAGCATCTCAAGCAACACGAGAAGAACAAGGGACACGCCTCGAAGGACTCGTCCTTCTCCCAGGAGGACTCCGGTCGCGAGGAAGCCAACGAGGAAGAGGTCGAACGCGACGCGGCCCGACAGTCCGAGGCGACCAGTCGCGTCACCGGCCCCGACGACAAACCGAACCACCTCGAGGACCAGCGGGCAACGAATACGAGAAACGAGGCGAGCCCGAGACGATCGTCGCGTAGTGAGATCTCGAGTTGCGACAAGTGTCCGGAGAACTTCGCCGGCCGATGCGAGCTCTCGGAGCACTCGAAAAACGAACACTCGGCGACCTTCAAGTGCAACACTTGCGAGCGAGAGTTCGACGGCCTGGAGAAACTCCGGAGACACAGAAGCGAGCACGTGGTCGAGGGCGTACTGTCGCAGCAGGATCTCGAGGGCAATTTATACGTGAGCGAGTTCGTTGCGAAGGTGCGCGACAACAGCGCCACCTACGAGAAGAGCGTCGAACTCGCGACGAGTCGCAACGAGGCGAACGAGCCCGACGAGGACTCGGCCGATCGGGCCGACAGTTCCTGGCCCCTCGCGATCGCCCACGAGGACGAGATCGATCAAGAGGACGTCAAGGACGTACGTTTGAACGACGACACCTGGCCCGAGCACAACAATCACGATTGTTCCACTCACGTCGCCACTTGCTCCGCCAAAAAGTCCCTCGAACGACACGCGGACCATCACGAGACGCGAACGAAACACTCGTGCAAATTTTGCCATGCCGTATTCACCACGAAGGACAATCTCAGGCGTCACGTCGAGCAAGAGTGGGCCTGCGGAACGAGAACCTTCAAGTGCACCGACTGCGGCAAAACTTTCGGCAACGAGCTCACGTTGCGCAACCATTTGTTCGCGACGAGTCACAAAACAATCGTACACGGACAGCCTTACGATGCGAACAAGCGAATGAAGCGAGTGGCGGCCAAAGCGGCGCAAAAGATCATCGACAAGATCAAGACCGAGGACGATCACGAGTCCTCGGAGTCCTCGAGCGACGAGATCAAAACGGAGATCCATTGCGAGGAGGGGACGAGCTCGCGAGACTCGAAAATCAACAGCAGTCCCCGTTGGAGCCGTCAAGACGAAGAAGCAACGGGCAAAATAATCGCGAGTCGCAATCGTCGAAGGCACAATTACGAGTGCGAGAGCTGCGGCCGCAAGTGCCGATCCAAGCAATCACTCGCGAAGCACGTGTCGCAGCATCGCGCCAAAGATTCCGCACTCGAGGCCCCTGACAAAACGGAACGACGAGCCGTGACGACCAGCCGACTGCCGGAGAAATCGTGCAACCTCCAACCGTCGAGCAAACCCACGAGCCTCAGGCGCGACGTTAAactcgaggacgacgaggataACGAGAATTCGGACTTCGAGAGCGGCCTCGACTGGCCGATCGACAGTCACGAGTGTCCCACGTGCAAGAAGAAGTACAGCACGAAAAAGTCCCTGCTGCGTCATCAGCTGCTACACGAGAAGCCGAACTTCGAGTGCGACATATGCAACGTGAAGTTTTACCGCAAGGACAAGCTCAAGTCGCACTACGACAAGTGCTCGGAGAAGAATCCCGATCAGGTGCGCAAGTGCAACATATGCGGCGAGATATTCGAGAACAACGAGATACTGCGCGAGCACAGGGGACGTCACGTCGACGAGGGCCTGCTGACGGAGGAGGATCTGCGGGAACTCGAGCCGGGCACGGAGGACAGACGAGACGGCGGAAAAGTCGCCCGGAAACGGCGCACCGACATCGTCGGCCTCGAATGCACCGAGTGCAACAAACGCTACACCTCGAGGAAAGGCCTGCTGCGACACATACAAGTACACGAGGGCAAAAAGTATCTGTGCGACATATGCCCGAAGAAGTTTTATCGTCGCGAACATCTCAAGATTCACGTTGCCAAGCACAACATGATCAAGCCTTACAAGTGTCCCCGTTGCACGAAACGCTTCATCAAGGAGGAACAATTGTCGAATCACTTGTCCAAGCACGATCGTACCTTCAAGAAGCCCAAAGAGGCCGACACCTCCAAACGATTCCTGTGCGAGATTTGCTCGAAAAGCTTCACTCAGTCGACGACGCTTATCGCTCATCTGCGCGCTCACAACGGCATCAAGCCATACGTGTGCGAAGTCTGCGCCCGACCCTTCACCACCAACGCCTATCTCAAGATGCACATGAGGACCCACACCCAGGAACGACCCTACAGCTGCCAGTACTGCTCGAGGGCTTTCGCCCGCGCCGACACCCTCGCCAATCATCTCACATCACACACCGGCGAGGCCAAGTATCATTGCAAATATTGCCCGAAAAACTTTCGACGTCTCAAGTCCCTCAAGGAACACGTGTTCATACACACCGGGCAGAGACCCTACGCGTGTCCCACCTGCGATCGTCGATTCAACAACAACGGCAGCCGATACGCGCACAGCAAACGGTGCAAACTGAATCATCTTCAGCCTACCGGAAGTCGAGCACAGACCTCGATACCGGACAGCCCGGTGCTCCAGGAACATCTCGTACAACCCATCAGGCTACATCAGCTCAACGAGGCCCACGAATTACTCGACGAACACGAGGAACATCAGACGCAGATACAACTGGTCAAGTCGCAAGGCATCAAGACAATCACCATCACGAGAACCACCGACGATCTCACCGGGGCCCAGATGATGCAACATCAAGAAATTCTCATGCCCCTCATACTACCGCTCACCGTTACGCTCACCGACGCCGACGAGGAAGTCATCCTTCCCGAAGGCACGAAAATATACACCACTGCCTAA
Protein Sequence
MDAVEMNVAEDSPEEAIEETVPEICRVCLLGHMITRDLFVENNAVSLSTKAMSFASVKMAPEDGLPARVCCDCADKLEAAYEFKLQVEQADNVLRQRYDGPNIKDELFFNEVEVHLEVERGDDAHSLTVDARYQATVDSLNAVVPVEAKSTLLKDHLALLEVAKLAKQQGVLEVHGNFGAEKRIQRLANVRRENEPRTGEPEVGYAFAGLTGKNLTYATFLETRILPLESSQDKDDGVSDEEESGVSAMLRANEQHYLDETEGAVVELDDCAEAYRDSAKSEGLPDGITAEEHNYIMQQGYELTRNGEDLVGAQESVDSVNESDNYLSLIDDEMNTAKETEVAQPEVGEINEEAQTEVGPVETDVTTEETSPGETRRSKRKANKRRRTVSEEDNYFENLSLSSRLKQAQLEKNEKFYFLCYLCDKRFVSKDILKEHMRSHAEVRRALSLRKAERSDRRGSTSPTKTSNVENSTSSGKKANKCPHCGKEYLYVISFNKHLKQHEKNKGHASKDSSFSQEDSGREEANEEEVERDAARQSEATSRVTGPDDKPNHLEDQRATNTRNEASPRRSSRSEISSCDKCPENFAGRCELSEHSKNEHSATFKCNTCEREFDGLEKLRRHRSEHVVEGVLSQQDLEGNLYVSEFVAKVRDNSATYEKSVELATSRNEANEPDEDSADRADSSWPLAIAHEDEIDQEDVKDVRLNDDTWPEHNNHDCSTHVATCSAKKSLERHADHHETRTKHSCKFCHAVFTTKDNLRRHVEQEWACGTRTFKCTDCGKTFGNELTLRNHLFATSHKTIVHGQPYDANKRMKRVAAKAAQKIIDKIKTEDDHESSESSSDEIKTEIHCEEGTSSRDSKINSSPRWSRQDEEATGKIIASRNRRRHNYECESCGRKCRSKQSLAKHVSQHRAKDSALEAPDKTERRAVTTSRLPEKSCNLQPSSKPTSLRRDVKLEDDEDNENSDFESGLDWPIDSHECPTCKKKYSTKKSLLRHQLLHEKPNFECDICNVKFYRKDKLKSHYDKCSEKNPDQVRKCNICGEIFENNEILREHRGRHVDEGLLTEEDLRELEPGTEDRRDGGKVARKRRTDIVGLECTECNKRYTSRKGLLRHIQVHEGKKYLCDICPKKFYRREHLKIHVAKHNMIKPYKCPRCTKRFIKEEQLSNHLSKHDRTFKKPKEADTSKRFLCEICSKSFTQSTTLIAHLRAHNGIKPYVCEVCARPFTTNAYLKMHMRTHTQERPYSCQYCSRAFARADTLANHLTSHTGEAKYHCKYCPKNFRRLKSLKEHVFIHTGQRPYACPTCDRRFNNNGSRYAHSKRCKLNHLQPTGSRAQTSIPDSPVLQEHLVQPIRLHQLNEAHELLDEHEEHQTQIQLVKSQGIKTITITRTTDDLTGAQMMQHQEILMPLILPLTVTLTDADEEVILPEGTKIYTTA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-