Basic Information

Gene Symbol
Foxk1
Assembly
GCA_001266575.1
Location
JTDY01001689.1:33856-45589[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 1.6e-22 1.6e-19 69.7 0.1 3 59 227 282 225 301 0.91
2 5 0.0029 2.9 8.0 0.2 2 14 344 356 343 357 0.93
3 5 0.009 9 6.4 0.0 70 85 357 372 355 375 0.84
4 5 0.0054 5.3 7.1 0.0 67 85 398 416 390 419 0.82
5 5 0.0053 5.3 7.1 0.0 67 85 442 460 433 463 0.82

Sequence Information

Coding Sequence
ATGCCAGACAGGAGAGACGTACGGATAGGGCGCGTCGCGACACGGGACGGAGTGTGGACCTGCCAATTCGTCCACTCACGACACGTTACGGCCACAGCACGACAACAGACGCAGGAATGCGTGGAATGGCACCACACGCCTCTGCGTGCAACATCTAGGGCGCAGACGATGAAGCGTTGCCCTCGCGGCCGTCTCCTGTATAATTGCCCAACGTTCCAACTCGAGCTCGAGCCCGAGTGTGTGGAAGGAAGGCTCGGTCGAGTTGGCCATGCTAGATTGCCCGAAATCGACCGCGAGTCGAAGGAGCTCGCTAGCGTTTTGCAAGTCACAGTTTTTGCAGACACATCAGGGCGCGCGAAGCCGGCGACAGAcTTCCAATCTCTGGTGGAGGAGAGCGGCGCTGGCGGCAGCGCTGCGCCCATGCCGCCGCTCCGCATCACCATACCCACAGACAATGATGGCCGAAGCCCTGCGCCTTCGCCTACTGAGCCCCGGCAAGGGTCCAACGGCACTGGTGTGAGTACCACGACACATGTTCCAGGCACAATAAGTGCGGCCAACAGTTGTCTCACGTCCCCTCGGGGCGCCGGCTCGTCGGGCCGGCGACACGTCGACCTCGGGCTGGTGGCGCACTACAGCGCACTGGCAGAGCCCCGGCAAGGGTCCAACGGCACTGGTCCGCCGTACAGCTACGCGCAGCTCATCGTGCAGGCCGTTGCCTCCGCGCAGGACAAGCAGCTCACCCTCAGCGGCATCTACAGCTACATCACCAAGCACTACCCTTACTACCGCACGGCGGACAAGGGCTGGCAGAACTCGATACGCACAGTAAGTGCGGCCAACAGTTGTCCCACGTCCCCTCAGGGCGCCGGCTCGGCGACCTCGGGCTGGTGGCGCACTACAGCGCACTGGCAGAGCCCCGGCAAGGGTCCAACGGCACTGGTATCCTCAACGCACTCGGACTCGGGCTATGTCAGCTCGCGCGACGTGCGCGAGACGCGTGACGCGCGCGAGGCGCGTGACGACGCCAAGCCGCCGTACAGCTACGCGCAGCTCATCGTGCAGGCCGAGCCCGGCAAGGGAAGCTTCTGGCGCATTGACCCTCAGAGCGAGGGCAAGCTCATCGAGCTGGCGTTCCGGCCGCGGCGCCCGCGCGGCGTCCAGTTCCGAGCGCCCTTCGGCCTCTCCTCCAGCGAGCAAGATGCTGGCAAGGGCAGCTTCTGGCGCATCGACCCTCAGAGCGAGGGCAAGCTCATCGAGCTGGCGTTCCGGCCGCGGCGCCCGCGCTGCGTCCAGTTCCGACCGCCCTTCGGCCTCTCCTCCAGCGAGCAAGATGCTGGCAAGGGCAGCTTCTGGCGCATCGACCCTCAGAGCGAGGGCAAGCTCATCGAGCTGGCGTTCCGGCCGCGGCGCCCGCGCGGCGTCCAGTTCCGAGCGCCCTTCGGCCTCTCCTCCAGATGCTGGCAAGGGCAGCTTCTGGCGCATCGACCCTCAGAGCGAGGGCAAGCTCATCGAACTGGTGTTCCGGCCGCGGCGCCCGCGCGGCGTCCAGTTTCGAGCATCTTTCGGCCTCTCCTCCAGCGCATCGACCCTCAGAGCGAGGGCAAGCTCATCGAGCTGGCGTTCCGGCCGCAGCGCCCGCGCGGCGTCCAGTTCCGAGCACCCTTCGGCCTCTCCTCCAGGAGTGCGCCGACGTCGCCGTCCCAGGTGGGCGTGTCGGGGCTGGTCACGCCGGAGGAGCTGTCCCGCGAGCCCACGCCCGATCTCTTCACCGGGGAGGAACATGACCAGCAGATCACCGTCGTCACCAACGGCGCTGGCGGCGAGAGGGAAGGTAACACCACACTCatctga
Protein Sequence
MPDRRDVRIGRVATRDGVWTCQFVHSRHVTATARQQTQECVEWHHTPLRATSRAQTMKRCPRGRLLYNCPTFQLELEPECVEGRLGRVGHARLPEIDRESKELASVLQVTVFADTSGRAKPATDFQSLVEESGAGGSAAPMPPLRITIPTDNDGRSPAPSPTEPRQGSNGTGVSTTTHVPGTISAANSCLTSPRGAGSSGRRHVDLGLVAHYSALAEPRQGSNGTGPPYSYAQLIVQAVASAQDKQLTLSGIYSYITKHYPYYRTADKGWQNSIRTVSAANSCPTSPQGAGSATSGWWRTTAHWQSPGKGPTALVSSTHSDSGYVSSRDVRETRDAREARDDAKPPYSYAQLIVQAEPGKGSFWRIDPQSEGKLIELAFRPRRPRGVQFRAPFGLSSSEQDAGKGSFWRIDPQSEGKLIELAFRPRRPRCVQFRPPFGLSSSEQDAGKGSFWRIDPQSEGKLIELAFRPRRPRGVQFRAPFGLSSRCWQGQLLAHRPSERGQAHRTGVPAAAPARRPVSSIFRPLLQRIDPQSEGKLIELAFRPQRPRGVQFRAPFGLSSRSAPTSPSQVGVSGLVTPEELSREPTPDLFTGEEHDQQITVVTNGAGGEREGNTTLI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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