Obrm004691.1
Basic Information
- Insect
- Operophtera brumata
- Gene Symbol
- Foxn3
- Assembly
- GCA_001266575.1
- Location
- JTDY01001108.1:22031-52806[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1.3e-30 1.3e-27 95.7 0.3 1 67 137 202 137 205 0.96 2 5 1.6e-16 1.6e-13 50.4 1.4 29 67 206 243 203 248 0.92 3 5 2.1e-16 2.1e-13 50.1 1.5 29 67 247 284 244 287 0.92 4 5 2.1e-16 2.1e-13 50.1 1.6 29 67 288 325 285 329 0.92 5 5 1.1e-14 1.1e-11 44.6 0.7 29 64 329 363 326 371 0.92
Sequence Information
- Coding Sequence
- ATGACGATTCCTATTGTGGCGCTGAAGCGGTTTGGTAACTGTCGTTGTGATGCGTTGACGTCACGTGACAAATACGTCGATGTGACCAGATTGCGTGTGTTCATGGCGCCGATGCGCGGAGAGCGCGGTGGATCCCCGGCCCGCGGCGTGCGTGCCACGCTTCCCCTGCCCCGTCGGCTGATCAGGCAGATCGCGAGACACGTGGCGTCCAGCGGACGATCCCTCAGGCGCCTTGAGGTCTCAGGCCGTGTCATAGACAACTTTGACGACATTGAAGGAGTTTCCGACGAATCTGATATGGAAATGGCGCAACCAGCACCACCCTCCCCTCCCCGCACACCGGTCAAAGCGCCCCCCTCTCCTCCTACTCCCCCCACCCCAACTCCACCCCCCAACCTTCAAACCCACCAAAAACCTCCGTACTCCTTCTCGTGTCTCATCTTCATGGCTATAGAGGCTGCTCCAGCCAGGGCGTTGCCGGTGAAGGAAATATACGCGTGGATTATACGTCACTTTCCGTACTTCAAACACGCTCCGCAGGGCTGGAAGAACAGTGTGCGGCACAACCTGTCCTTGAATAAGTGCTTCCATAAGACACACCAGAAACACGCTTGGTACACTAGTATTATACGTCACTTTCCGTACTTCAAACACGCTCCGCAGGGCTGGAAGAACAGCGTGCGGCACAACCTGTCCTTGAATAAGTGCTTCCATAAGACACACCAGAAACACGCTTGGTACACTAGTATTATACGTCACTTTCCGTACTTCAAACACGCTCCGCAGGGCTGGAAGAACAGTGTGCGGCACAACCTGTCCTTGAATAAGTGCTTCCATAAGACACACCAGAAACACGCTTGGTACACTAGTATTATACGTCACTTTCCGTACTTCAAACACGCTCCGCAGGGCTGGAAGAACAGTGTGCGGCACAACCTGTCCTTGAATAAGTGCTTCCATAAGACGCACCAGAAACACGCTTGGTACACTAGTATTATACGTCACTTTCCGTACTTCAAACACGCTCCGCAGGGCTGGAAGAACAGTGTGCGGCACAACCTGTCCTTGAATAAGCGCTTCCATAAGGCATTCGGTCGTCAACCGATCCCGGCCGCGGCGCCCGACTCGCCACCAGCCGGCGCCAAGAACTCGCCAGATCCGTCACTCTTCCCGTTCCTGGCGCGCCGCCTCGCAGGCTCGCCGGAGCCTGGCGCGGACGAGTACTTAGCAGCCGCAACCGTGCTCGCAATGAAATACGGTCCGGCCGTGCTGTCTCAGCTCCCACCAGCCGCGCACCTGGTGATATCGCGCTGCGCTCGCGACGAGCACTCGTACAGCGGCTGCGAGGAGCGCCGCACGGCCGAGGCGCTGCTCAACCTCGCTGGCGTGCGGTGTTACTTCATTGGGAAAcctgcatag
- Protein Sequence
- MTIPIVALKRFGNCRCDALTSRDKYVDVTRLRVFMAPMRGERGGSPARGVRATLPLPRRLIRQIARHVASSGRSLRRLEVSGRVIDNFDDIEGVSDESDMEMAQPAPPSPPRTPVKAPPSPPTPPTPTPPPNLQTHQKPPYSFSCLIFMAIEAAPARALPVKEIYAWIIRHFPYFKHAPQGWKNSVRHNLSLNKCFHKTHQKHAWYTSIIRHFPYFKHAPQGWKNSVRHNLSLNKCFHKTHQKHAWYTSIIRHFPYFKHAPQGWKNSVRHNLSLNKCFHKTHQKHAWYTSIIRHFPYFKHAPQGWKNSVRHNLSLNKCFHKTHQKHAWYTSIIRHFPYFKHAPQGWKNSVRHNLSLNKRFHKAFGRQPIPAAAPDSPPAGAKNSPDPSLFPFLARRLAGSPEPGADEYLAAATVLAMKYGPAVLSQLPPAAHLVISRCARDEHSYSGCEERRTAEALLNLAGVRCYFIGKPA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -