Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 3.3 3.7e+03 -1.8 0.0 17 32 22 35 16 54 0.47

2 7 0.00031 0.34 11.1 1.0 16 50 131 165 119 169 0.84

3 7 1.8 2e+03 -0.9 0.1 26 43 170 187 164 193 0.68

4 7 0.00057 0.63 10.3 0.1 20 48 193 221 182 224 0.86

5 7 0.001 1.1 9.5 0.1 21 48 223 250 219 256 0.90

6 7 0.76 8.5e+02 0.3 0.1 17 48 248 279 247 280 0.80

7 7 3.5e-05 0.039 14.2 0.7 17 50 277 310 264 312 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	3.3	3.7e+03	-1.8	0.0	17	32	22	35	16	54	0.47
2	7	0.00031	0.34	11.1	1.0	16	50	131	165	119	169	0.84
3	7	1.8	2e+03	-0.9	0.1	26	43	170	187	164	193	0.68
4	7	0.00057	0.63	10.3	0.1	20	48	193	221	182	224	0.86
5	7	0.001	1.1	9.5	0.1	21	48	223	250	219	256	0.90
6	7	0.76	8.5e+02	0.3	0.1	17	48	248	279	247	280	0.80
7	7	3.5e-05	0.039	14.2	0.7	17	50	277	310	264	312	0.92

Coding Sequence: ATGGAAAATTTCTGCACTCAAGCTCTATCAGAAGGTGAGATTTATGACACTGAACGAAATGAAGCGTCTTCAAGCTCCCCAGTCCCTATGTTTGTGTGCTATCTCTGCAACTTTAGTGGGGAATGTGAGGATTCTCTCAGGACTCACTTGATTGAAGAACATGCTGAAGAGTATCTTCCTAATAAGCAAGAAGTTTCTTCTCCCTCTTCTGAGCAGATAACGTGGAATGCTGATGAACAGATTTATTACTGCAAACAATGCGAATACAAATCATGTGACTTCAACCAAATGGAGGAACACATGATGTCTATGCACCCTGGTGAACAATCATATTCTTGTATACAATGTGATTATAAATCAACTTTCCCTGGCAACTTGAAAAAACACATAAAAGCTAAACATTCCAGTGAATTGCCTTATTCTTGTAAACATTGTGAGTATAAATCTTCTTTTTCCCATAACTTAAAGAGACACATAAGAATTAAACATGAAATAACACCTTATTTTACATGTCCATATTGTGAGTACAAATCACTTCATTCAAGTACCATGAAGACTCACATGATGTCTTTGCACACTGGTGAACGACCTTACTCCTGTCCATATTGTGAGTATAAATCCGTTCAGTCCAGTAACATTAAGAAACATATAATGACTTCTCATACTGGTGAACGACCTTATTCCTGTACTTTCTGCTCTTATAAATCAGCTCAGTCTGGCAATGTAAAGAGACATATGATGTCTAAACATACCGGTGAACGACCTTATTCCTGTGCACATTGTGATTACAAGTCAGCTCATTCTACCCACTTAAAGTCACATATAATATCCAAACATACCAGTGAACGACCTTATTGCTGCCCATATTGTGATTACAAATCAGCACAGTTTGTAAATTTTAAGAAACACATGAAGGCTAGACATCTCAATCGAGAATAA
Protein Sequence: MENFCTQALSEGEIYDTERNEASSSSPVPMFVCYLCNFSGECEDSLRTHLIEEHAEEYLPNKQEVSSPSSEQITWNADEQIYYCKQCEYKSCDFNQMEEHMMSMHPGEQSYSCIQCDYKSTFPGNLKKHIKAKHSSELPYSCKHCEYKSSFSHNLKRHIRIKHEITPYFTCPYCEYKSLHSSTMKTHMMSLHTGERPYSCPYCEYKSVQSSNIKKHIMTSHTGERPYSCTFCSYKSAQSGNVKRHMMSKHTGERPYSCAHCDYKSAHSTHLKSHIISKHTSERPYCCPYCDYKSAQFVNFKKHMKARHLNRE

Sequence clustering based on sequence similarity using MMseqs2